Épisodes

  • The One Test That Never Expires: Why Your DNA Is the Most Important Thing You'll Ever Test

    The One Test That Never Expires: Why Your DNA Is the Most Important Thing You'll Ever Test
    Sep 18 2026

    I ran 70,000km across the world's toughest deserts to lose weight, and I got heavier, more inflamed and sicker every year. I assumed the problem was discipline. It took one genetic test to show me it never was.

    In this solo episode I make the case that your DNA is the single most valuable test you will ever do. Not because it tells you the most, but because it is the only test whose result is still true in fifty years. Your bloods reflect the last few weeks. Your microbiome shifts with every trip and every course of antibiotics. Your hormones move across the month and the decade. Your DNA does not move at all.

    I go through all eight areas a comprehensive genetic panel covers, what you actually learn from each one, and why a variant is a tendency rather than a verdict.

    IN THIS EPISODE

    My own results, and the cascade that explains twenty-five years of getting it wrong
    Why genetics is different from every other test you will ever do
    Genetics loads the gun, environment pulls the trigger: what that actually means in practice
    The single-gene trap, and why the MTHFR obsession has it upside down
    Digestion, energy, hormones, stress and cognition, inflammation, athletic performance, DNA repair and detoxification, one at a time
    The difference between nutritional dosing and nutrigenomic dosing, and why more vitamin D was not working for me
    Why genetics alone is not enough, and what has to sit alongside it
    Why it is almost never discipline

    THE DNA BLUEPRINT PACKAGE

    Practitioner-only genetic testing, ninety-two genes and a hundred and thirteen variants across a report of roughly a hundred and twenty-one pages, read by me alongside a full Cell Blueprint assessment and turned into a complete personal health programme in a ninety-minute one-on-one.

    Available throughout New Zealand. Australia coming soon.
    https://www.lisatamati.com/dna/

    GO DEEPER

    Dr Sam Shay on methylation, inflammation and exercise-induced obesity:
    https://www.lisatamati.com/podcast--dr-sam-shay_1/

    Dr Mansoor Mohammed on how your variants change what you eat and how you train:
    https://www.lisatamati.com/podcast-mansoor-mohammed/

    Read the long-form article:
    https://www.lisatamati.com/blog/

    ALSO FROM LISA

    Re:juvenate Pro, the foundational immune ageing formula from Aevum Labs:
    https://shop.lisatamati.com/pages/rejuvenate

    Re:NRG, our next-generation NAD support, is coming. Join the waitlist for first access:
    https://shop.lisatamati.com/pages/nad-next-gen-waitlist

    Weekly longevity insights, free:
    https://www.lisatamati.com/lisa

    Questions or feedback: lisa@lisatamati.com

    Pushing the Limits is hosted by Lisa Tamati, genetics practitioner, co-founder and Chief Science Officer of Aevum Labs, and former professional ultra-endurance athlete. Author of three books and one audiobook.
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    1 h et 5 min
  • Your Immune System Is Aging Faster Than You Are

    Your Immune System Is Aging Faster Than You Are
    Jul 5 2026

    Your Immune Age Is Lying To You. Here's How To Read Your Blood And Fix It.

    How old is your immune system, really?

    It's probably not the same age as you are — and that gap may be the single biggest hidden driver of how well you age, how fast you recover, and how long you stay healthy. In this episode I break down what actually happens to your immune system as the years tick over — immunosenescence (the immune system getting weaker) and inflammaging (the silent, smouldering inflammation that never switches off) — and why almost every disease of ageing sits somewhere on that spectrum.

    Then I get practical. I'll show you how to measure your immune age from a standard blood test you can get anywhere in the world, using seven scientifically validated ratios (NLR, PLR, MLR, LMR, SII, PIV and ELR) synthesised into a single Immune Resilience Index. We cover the cutting-edge science from Dr David Furman's 1000 Immunomes Project and the iAge inflammatory clock, the TRIIM and TRIIM-X thymus-regeneration trials, the gut-immune connection (70% of your immune cells live in your gut), the cytokines of ageing (IL-6, TNF-alpha, IL-1 beta, NF-kB and IL-10), and how our Re:juvenate Pro formulation was built to target exactly these pathways. If you want to stop guessing and start tracking the system that runs your healthspan, this one's for you

    RELATED EPISODES — WATCH THESE NEXT

    Dr David Furman | The 1000 Immunomes Project and the inflammatory clock of aging: https://www.youtube.com/watch?v=HFOSqEY7CNY

    Dr Rod Claycomb | Colostrum, immune proteins and immune resilience: https://www.youtube.com/watch?v=VyOfcx9gvbE

    Aevum Labs panel | Peter Lehrke, medical herbalist Mike Eyres and Dr Rod Claycomb: https://www.youtube.com/watch?v=EstwHB3p3nI

    Dr Elizabeth Yurth | Immune aging and how to slow it: https://www.youtube.com/watch?v=h_-_rFXcBIA

    THE SCIENCE + RE:JUVENATE PRO Re:juvenate Pro at Aevum Labs: https://aevumlabs.co.nz/products/re-juvenate Aevum Labs: https://www.aevumlabs.co.nz

    🌐 Website: https://www.lisatamati.com

    🛒 Supplements: https://shop.lisatamati.com

    🎙️ Podcast: https://www.lisatamati.com/podcast

    📧 Contact: support@lisatamati.com
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    39 min
  • Professor Julia Rucklidge: Micronutrients, Mental Health and Why the RDAs Are Broken

    Professor Julia Rucklidge: Micronutrients, Mental Health and Why the RDAs Are Broken
    Jun 12 2026
    The link between micronutrients and mental health is one of the most overlooked stories in modern medicine, and Professor Julia Rucklidge has spent more than two decades proving it matters. In this episode of Pushing the Limits, she shares the research on micronutrients and mental health that has challenged psychiatry's drug-first model, showing that broad-spectrum vitamins and minerals can treat ADHD, depression and anxiety, often as effectively as medication and without the side effects. If you have ever wondered how deeply micronutrients and mental health are connected, this conversation will change how you think about your brain, your mood and the food you eat every day. Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research Lab. She is co-author, with Bonnie Kaplan, of The Better Brain, and her work has been published in leading psychiatry journals and viewed by millions through her TEDx talk. She came into this field as a sceptic, trained to believe that nutrition was irrelevant to the brain, and changed her mind only when the evidence became impossible to ignore. In this conversation, Julia explains what her clinical trials actually found, and why 60 to 80 percent of people respond to a broad-spectrum approach once you move past the noise of a blinded study. We talk about why feeding the whole system beats chasing a single nutrient, what the biomarkers reveal about inflammation, methylation and the microbiome, and why the RDAs were never designed to support an optimally functioning brain. She makes the case that the recommended daily allowances we rely on were built to prevent deficiency diseases, not to help the brain thrive, and that this gap matters enormously for anyone struggling with their mental health. We also explore the bigger forces at play: depleted soils and what modern agriculture has done to the nutrient density of our food, the rise of ultra-processed food and why Julia calls it the cigarette of the twenty-first century, and the antidepressant withdrawal that so many people are never warned about. She shares her frustration with New Zealand's outdated supplement regulations, where a product can be effectively banned for containing a fraction too much of a nutrient, and a distributor can be threatened with serious penalties for selling something that genuinely works. Most of all, this is a hopeful conversation. It is about taking back control of your health through the food on your plate, understanding the real connection between what you eat and how you feel, and recognising that small, consistent changes can have a profound effect on the brain. Whether you are a parent navigating a child's behaviour, someone managing your own mental health, or simply curious about the science of nutrition and the brain, this episode will give you a new lens on what is possible. If you have ever been told that nutrition is irrelevant to your brain, this episode is for you. Resources and mentions: The Better Brain by Bonnie Kaplan and Julia Rucklidge What Your Food Ate by David Montgomery and Anne Biklé Te Puna Toiora, Mental Health and Nutrition Research Lab, University of Canterbury Biography: 09:26   Claude responded: Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research L… Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research Lab. One of the world's leading researchers in nutritional psychiatry, she has spent more than two decades running placebo-controlled trials showing that broad-spectrum micronutrients can treat ADHD, depression, anxiety and stress, often as effectively as medication and without the side effects. She is co-author, with Bonnie Kaplan, of The Better Brain, and her TEDx talk on nutrition and mental health has been viewed millions of times. Based in Christchurch, New Zealand, she is on a mission to put nutrition where she argues it belongs: as a serious, evidence-based part of how we treat and prevent mental illness.
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    1 h et 8 min
  • R3HBG: The Bioidentical Ketone That Bypasses the Liver | Mike Chesne, Tecton Founder

    R3HBG: The Bioidentical Ketone That Bypasses the Liver | Mike Chesne, Tecton Founder
    May 30 2026
    What if there was an exogenous ketone that didn't go through the liver, didn't cause the GI distress of other ketones, and delivered bioidentical BHB directly to your cells? In this episode, Lisa sits down with Mike Chesne, founder of Tecton and retired US Army Special Forces combat medic, who spent 25 years in special operations before developing R3HBG — a patented ketone molecule that's categorically different from everything else on the market. Mike's journey from battlefield medicine to biotech is extraordinary. After suffering multiple traumatic brain injuries from IED blasts during nearly three years of combat, he went through brain injury rehabilitation and discovered the neuroprotective potential of ketones. He asked one question that changed everything: "If I had been in ketosis when I got blown up, how much better would my outcome have been?" That question led him to Oxford University, to Dr Kieran Clarke's lab, and eventually to designing his own molecule — drawing it on a napkin and spending over a decade turning it into a manufactured, FDA-reviewed product. In this deep-dive episode we cover: Mike's military career and the brain injuries that changed his pathThe DARPA project that spent $10 million searching for a supplement to boost performance and cognition by 30%Why the brain in Alzheimer's and TBI can't access glucose but can still take up ketones R3HBG explained: how lipase (not alcohol dehydrogenase) breaks it down, and why that mattersThe differences between BHB salts, R-1,3-butanediol, the original ketone ester, and R3HBGThe NLRP3 inflammasome and how BHB blocks the inflammatory cascade driving neurodegenerationHDAC inhibition and how BHB switches on your body's own antioxidant and longevity genesNDI #1354 and what FDA New Dietary Ingredient acceptance meansThe GLP-1 agonist connection for weight management and metabolic health Therapeutic dosing for cognition, endurance, and recovery Mike's vision to license R3HBG to every ketone company willing to use it Lisa's experience using ketones with her mother's brain injury and cancer recovery This is the most comprehensive ketone science episode we've ever produced. TECTON KETONES: Use this link for a discount https://tectonketones.com/discount/TAMATI While you're optimising your brain and metabolic health, give your body foundational support with Re:juvenate Pro, my advanced cellular health and longevity formula (https://shop.lisatamati.com/pages/rejuvenate), and explore my full curated range of anti-aging and longevity supplements at shop.lisatamati.com. CONNECT WITH LISA Website: lisatamati.com Shop: shop.lisatamati.com Newsletter: www.lisatamati.com/lisa Podcast: https://www.lisatamati.com/ptl-podcast/ Books: https://shop.lisatamati.com/collections/books Pushing the Limits is brought to you by Lisa Tamati and the team at lisatamati.com.
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    1 h et 41 min
  • INUSpheresis: Removing Toxins, Heavy Metals & Microplastics From Blood/ Tash Simons

    INUSpheresis: Removing Toxins, Heavy Metals & Microplastics From Blood/ Tash Simons
    May 20 2026
    What if the reason you're not getting better isn't about what you're putting in — but what you can't get out? In this episode I sit down with Tash Simons from INUSpheresis Perth — the first clinic in Australia and the Southern Hemisphere to offer this advanced blood filtration therapy. We go deep into how double filtration plasmapheresis works, the two specialised filters (TKM58 and INUS 30), and the science behind removing autoantibodies, inflammatory cytokines, heavy metals, microplastics, PCBs, and oxidised LDL directly from your blood — without involving your kidneys or liver. We cover the clinical research across long COVID, ME/CFS, autoimmune conditions, Lyme disease, Alzheimer's, and cardiovascular risk including Lp(a) — one of the hardest lipid markers to shift. Tash shares the personal story of how a family member's chronic fatigue led her and Dr Robbie Simons to discover this therapy in Vienna, and the journey to bring it to Perth — from TGA registration and insurance approvals to Swiss certification and over 100 treatments completed. If you're dealing with a chronic condition that won't budge, carrying a toxic load, or thinking about longevity from a subtractive medicine perspective — this one's for you. Book a consult or submit a new patient form at inuspheresisperth.com.au Check out my supplement store at shop.lisatamati.com Rejuvenate Pro at shop.lisatamati.com/pages/rejuvenate My books at shop.lisatamati.com/collections/books Sign up for my newsletter at www.lisatamati.com/lisa Listen to more episodes at www.lisatamati.com/ptl-podcast/ This episode is also brought to you by Rejuvenate Pro from Aevum Labs. If INUSpheresis is about taking the bad stuff out, Rejuvenate Pro is about protecting what stays behind. Featuring kawakawa, carnosic acid, Immunel colostrum extract and IDP (Immune Defense Protein), it targets the chronic systemic inflammation that silently drives aging. It's the first supplement in every protocol I build for my clients — and it should be in yours. Shop now at shop.lisatamati.com/pages/rejuvenate ━━━━━━━━━━━━━━━━━━━ 🌐 Website: https://www.lisatamati.com 🛒 Supplements: https://shop.lisatamati.com 📧 Contact: support@lisatamati.com ━━━━━━━━━━━━━━━━━━━━
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    53 min
  • Copper, Mitochondria Grey Hair & Autism: The Missing Link No One Is Talking About

    Copper, Mitochondria Grey Hair & Autism: The Missing Link No One Is Talking About
    May 15 2026

    Could a simple mineral deficiency be driving mitochondrial dysfunction in autism? In this episode I sit down with Melissa Atchley from MitoSynergy to hear her personal story of using BioCopper1 with her son on the autism spectrum — and the changes she saw that no one expected.

    I break down the science behind it: Dr Richard Frye's research showing Complex IV dysfunction in children with ASD, the brand new April 2026 Science Advances paper linking copper deficiency directly to ASD-like behaviours through mitochondrial damage and impaired myelination, and why the type of copper matters — Cu1+ vs Cu2+ — more than most people realise.

    We also cover MitoSynergy's new MitoActivator MAX (4x the strength of the standard formula), the hair greying reversal angle, athletic performance benefits, and practical dosing guidance. If you or someone you love is navigating autism, fatigue, grey hair, or just wants to understand why copper might be the most overlooked mineral in health — this one is worth your time.

    Get yours in my shop: https://shop.lisatamati.com/products/mitoactivator-max-max-strength-biocopper1-supplement-60-capsmitosynergy-mitoactivator-max?_pos=2&_sid=5c471c21c&_ss=r

    Or use code LisaTamati at Mitosynergy.com for your discount

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    52 min
  • Klotho, Peptides & Limitless Longevity — Dr. Alex Grinberg & Dr. Dave Jenkins

    Klotho, Peptides & Limitless Longevity — Dr. Alex Grinberg & Dr. Dave Jenkins
    May 4 2026
    These two doctors are building a clinic where the most advanced longevity therapies have no limits. Dr. Alexander Grinberg (Infinity Epigenetics, San Francisco) and Dr. Dave Jenkins (Bredesen-trained, 40+ years clinical experience) are combining peptide therapy, regenerative medicine, and personalised protocols at a level most people don't know exists. From Klotho protein restoring cognitive function in head injury patients to mitochondrial peptides that can rescue dying cells — this conversation covers the cutting edge of what's actually possible right now. About the Guests Dr. Alexander Grinberg MD is a physician, immunologist, and peptide therapy specialist practicing in San Francisco. He holds a fellowship from the Moscow Immunology Institute and consults internationally on advanced customised longevity protocols. He runs Infinity Epigenetics and teaches physicians in high-end integration of peptides, regenerative medicine, and genetic therapies. Dr. Dave Jenkins is a New Zealand-trained physician with 40+ years of clinical experience specialising in metabolic and neurological health. He is Bredesen Protocol (ReCODE) trained and runs a longevity clinic in Bali. He co-developed a Type 2 Diabetes reversal program now being published and reviewed by NZ's top diabetic specialists. In this episode Why Klotho protein may be one of the most powerful longevity interventions available — and the different delivery forms (protein injection, peptide fragments, gene therapy)Dr. Dave's clinical Klotho results: a doctor with chronic head injury returning to practice, and his own memory score jumping from the 66th to the 97th percentile in six weeksHow mitochondrial peptides (MOTS-c, SS-31, Humanin) work and why dosing wrong can be dangerous — especially in autoimmune and cancer history casesThe case for micro-dosing peptides and why skin testing should come firstPersonalised medicine taken to its extreme: harvesting a patient's own cells, expanding them in culture, and running accelerated longevity and cancer resilience tests before any interventionWhy peptide purity and sourcing is a serious safety concern — and what the clinic will do differentlyThe vision for a Pacific Island longevity clinic offering therapies unavailable in the US, EU, NZ, or Australia — with a social impact mission to address metabolic disease in local populationsOff-label repurposed drugs for cancer (metformin, ivermectin, doxycycline, mebendazole) and why the regulatory environment mattersHow custom peptides designed from a patient's own genome could replace pharmaceuticals entirely Resources mentioned Infinity Epigenetics — infinityepigenetics.comDr. Dave Jenkins — 🌐 https://youngerbyscience.com/ 🌐 https://theendofalzheimers.com
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    1 h
  • The 7 Reasons Your Cells Age (And How to Stop It) Dr Sandra Kaufmann

    The 7 Reasons Your Cells Age (And How to Stop It) Dr Sandra Kaufmann
    Apr 30 2026
    Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. 👉 FREE Longevity Cheat Sheet — subscribe to my weekly newsletter: https://www.lisatamati.com/lisa/ Description: Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Dr Sandra Kaufmann is a cell biologist, physician, and creator of the Kaufmann Protocol — the first comprehensive rating system for anti-aging supplements. In this episode she shares the off-label drugs, supplement stacks, and cellular strategies she uses daily to slow aging at the molecular level. We go deep on mast cell activation and its connection to aneurysms and heart attacks, why NAD infusions may be doing more harm than good, the three sirtuins you need to prioritise after 40, why she takes 70 supplements and 13 medications at low doses, and the SGLT2 inhibitor drugs that are regrowing healthy heart cells by clearing senescent zombie cells. This is one of the most important longevity conversations I have had on the show. ⏱️ TIMESTAMPS: 0:00 - Teaser: Senolytic drugs that regrow healthy heart cells 0:20 - Welcome and intro to Dr Sandra Kaufmann 1:38 - Sandra's background: cell biologist to longevity expert 3:14 - The Post-it note office and chasing the aging puzzle 8:33 - The Seven Tenets of Aging overview 10:19 - Tenet 3: Sirtuins, AMPK, mTOR, and circadian rhythms 11:54 - Tenet 4: DNA repair, proteostasis, autophagy 13:07 - Deep dive: Mast cells and tissue destruction 14:16 - Mast cells, heart attacks, and aneurysms 17:43 - Mastering the Mast Cell: Sandra's new publication 21:06 - Stress triggers mast cell degranulation 23:04 - Mast cell stabilisers: supplements and drugs 27:17 - Sirtuins 1, 3, and 6: the keys to cellular homeostasis 30:05 - Best activators: pterostilbene, DHM, fucoidan 33:38 - The NAD debate: NMN vs NR vs infusions 36:23 - Why NAD IV infusions are a bad idea 39:06 - Rotating NAD precursors: Sandra's approach 44:52 - NRF2 pathway and why daily glutathione is a mistake 50:05 - 70 supplements and 13 drugs at low synergistic doses 56:50 - Rapamycin: Sandra says no 57:51 - Metformin: 250-500mg not 2000mg 1:00:16 - The Flozins: glucose excretion plus senolytic activity 1:02:32 - Epalrestat: blocking the glucose to fructose conversion 1:04:41 - Sandra's 5 daily eye drops protocol 1:08:13 - Naringenin, nobiletin, and the orange peel stack 1:11:28 - Supplement roundup and the Kaufmann Rating System 1:15:23 - Where to find Dr Sandra Kaufmann SPONSOR MESSAGE This episode is brought to you by MitoSynergy. If you are looking for next-level mitochondrial support, MitoSynergy delivers bioavailable copper in a patented form that supports energy production at the cellular level. Head to mitosynergy.com/lisaTamati and you will get 10% off your order. And if you have not tried Re:juvenate Pro yet, this is the supplement I formulated with my biotech company Aevum Labs. It is not another NAD supplement. Re:juvenate Pro targets immunosenescence, the aging of your immune system, which sits upstream of so many of the problems Sandra and I discussed today. It contains kawakawa, carnosic acid, Immunel colostrum extract, and Immune Defense Protein working across multiple pathways including NRF2 activation, gut barrier support, and immune modulation. It is the first thing I put in every client protocol and it is what I give my mum every single day. You can grab it at https://shop.lisatamati.com/pages/rejuvenate 🔗 LINKS MENTIONED IN THIS EPISODE: Website: kaufmannprotocol. Website: kaufmannprotocol.com Clinical practice: kaufmannlongevity.com Instagram: instagram.com/kaufmannantiaging Books: amazon.com/stores/Dr-Sandra-Charlotte-Kaufmann/author/B07BDL1WV8 E-treatise: Mastering the Mast Cell (search Amazon) Club Exosome: quarterly in Las Vegas with Steve McCain ━━━━━━━━━━━━━━━━━━━━ 🌐 Website: https://www.lisatamati.com 🛒 Supplements: https://shop.lisatamati.com 🎙️ Podcast: https://www.lisatamati.com/podcast 📧 Contact: support@lisatamati.com ━━━━━━━━━━━━━━━━━━━━ About Lisa Tamati: Longevity specialist, functional health practitioner, co-founder of Aevum Labs (home of Rejuvenate Pro), and host of Pushing The Limits — a globally top-200-ranked health podcast. Author of 4 books.
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    1 h et 21 min