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Pushing The Limits

Pushing The Limits

De : Lisa Tamati
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Pushing The Limits with Lisa Tamati — your deep dive into longevity science, health optimisation, biohacking, and cutting-edge functional medicine. Lisa Tamati, longevity expert, integrative health practitioner, and author, interviews world-leading doctors, scientists, and researchers at the frontier of healthspan extension, cellular health, metabolic health, hormonal optimisation, and anti-ageing medicine. If you want to live longer, think sharper, and perform better at every age — this is your show. www.lisatamati.com© 2024 Hygiène et vie saine Maladie et pathologies physiques Médecine alternative et complémentaire
Épisodes
  • The One Test That Never Expires: Why Your DNA Is the Most Important Thing You'll Ever Test

    The One Test That Never Expires: Why Your DNA Is the Most Important Thing You'll Ever Test
    Sep 18 2026

    I ran 70,000km across the world's toughest deserts to lose weight, and I got heavier, more inflamed and sicker every year. I assumed the problem was discipline. It took one genetic test to show me it never was.

    In this solo episode I make the case that your DNA is the single most valuable test you will ever do. Not because it tells you the most, but because it is the only test whose result is still true in fifty years. Your bloods reflect the last few weeks. Your microbiome shifts with every trip and every course of antibiotics. Your hormones move across the month and the decade. Your DNA does not move at all.

    I go through all eight areas a comprehensive genetic panel covers, what you actually learn from each one, and why a variant is a tendency rather than a verdict.

    IN THIS EPISODE

    My own results, and the cascade that explains twenty-five years of getting it wrong
    Why genetics is different from every other test you will ever do
    Genetics loads the gun, environment pulls the trigger: what that actually means in practice
    The single-gene trap, and why the MTHFR obsession has it upside down
    Digestion, energy, hormones, stress and cognition, inflammation, athletic performance, DNA repair and detoxification, one at a time
    The difference between nutritional dosing and nutrigenomic dosing, and why more vitamin D was not working for me
    Why genetics alone is not enough, and what has to sit alongside it
    Why it is almost never discipline

    THE DNA BLUEPRINT PACKAGE

    Practitioner-only genetic testing, ninety-two genes and a hundred and thirteen variants across a report of roughly a hundred and twenty-one pages, read by me alongside a full Cell Blueprint assessment and turned into a complete personal health programme in a ninety-minute one-on-one.

    Available throughout New Zealand. Australia coming soon.
    https://www.lisatamati.com/dna/

    GO DEEPER

    Dr Sam Shay on methylation, inflammation and exercise-induced obesity:
    https://www.lisatamati.com/podcast--dr-sam-shay_1/

    Dr Mansoor Mohammed on how your variants change what you eat and how you train:
    https://www.lisatamati.com/podcast-mansoor-mohammed/

    Read the long-form article:
    https://www.lisatamati.com/blog/

    ALSO FROM LISA

    Re:juvenate Pro, the foundational immune ageing formula from Aevum Labs:
    https://shop.lisatamati.com/pages/rejuvenate

    Re:NRG, our next-generation NAD support, is coming. Join the waitlist for first access:
    https://shop.lisatamati.com/pages/nad-next-gen-waitlist

    Weekly longevity insights, free:
    https://www.lisatamati.com/lisa

    Questions or feedback: lisa@lisatamati.com

    Pushing the Limits is hosted by Lisa Tamati, genetics practitioner, co-founder and Chief Science Officer of Aevum Labs, and former professional ultra-endurance athlete. Author of three books and one audiobook.
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    1 h et 5 min
  • Your Immune System Is Aging Faster Than You Are

    Your Immune System Is Aging Faster Than You Are
    Jul 5 2026

    Your Immune Age Is Lying To You. Here's How To Read Your Blood And Fix It.

    How old is your immune system, really?

    It's probably not the same age as you are — and that gap may be the single biggest hidden driver of how well you age, how fast you recover, and how long you stay healthy. In this episode I break down what actually happens to your immune system as the years tick over — immunosenescence (the immune system getting weaker) and inflammaging (the silent, smouldering inflammation that never switches off) — and why almost every disease of ageing sits somewhere on that spectrum.

    Then I get practical. I'll show you how to measure your immune age from a standard blood test you can get anywhere in the world, using seven scientifically validated ratios (NLR, PLR, MLR, LMR, SII, PIV and ELR) synthesised into a single Immune Resilience Index. We cover the cutting-edge science from Dr David Furman's 1000 Immunomes Project and the iAge inflammatory clock, the TRIIM and TRIIM-X thymus-regeneration trials, the gut-immune connection (70% of your immune cells live in your gut), the cytokines of ageing (IL-6, TNF-alpha, IL-1 beta, NF-kB and IL-10), and how our Re:juvenate Pro formulation was built to target exactly these pathways. If you want to stop guessing and start tracking the system that runs your healthspan, this one's for you

    RELATED EPISODES — WATCH THESE NEXT

    Dr David Furman | The 1000 Immunomes Project and the inflammatory clock of aging: https://www.youtube.com/watch?v=HFOSqEY7CNY

    Dr Rod Claycomb | Colostrum, immune proteins and immune resilience: https://www.youtube.com/watch?v=VyOfcx9gvbE

    Aevum Labs panel | Peter Lehrke, medical herbalist Mike Eyres and Dr Rod Claycomb: https://www.youtube.com/watch?v=EstwHB3p3nI

    Dr Elizabeth Yurth | Immune aging and how to slow it: https://www.youtube.com/watch?v=h_-_rFXcBIA

    THE SCIENCE + RE:JUVENATE PRO Re:juvenate Pro at Aevum Labs: https://aevumlabs.co.nz/products/re-juvenate Aevum Labs: https://www.aevumlabs.co.nz

    🌐 Website: https://www.lisatamati.com

    🛒 Supplements: https://shop.lisatamati.com

    🎙️ Podcast: https://www.lisatamati.com/podcast

    📧 Contact: support@lisatamati.com
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    39 min
  • Professor Julia Rucklidge: Micronutrients, Mental Health and Why the RDAs Are Broken

    Professor Julia Rucklidge: Micronutrients, Mental Health and Why the RDAs Are Broken
    Jun 12 2026
    The link between micronutrients and mental health is one of the most overlooked stories in modern medicine, and Professor Julia Rucklidge has spent more than two decades proving it matters. In this episode of Pushing the Limits, she shares the research on micronutrients and mental health that has challenged psychiatry's drug-first model, showing that broad-spectrum vitamins and minerals can treat ADHD, depression and anxiety, often as effectively as medication and without the side effects. If you have ever wondered how deeply micronutrients and mental health are connected, this conversation will change how you think about your brain, your mood and the food you eat every day. Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research Lab. She is co-author, with Bonnie Kaplan, of The Better Brain, and her work has been published in leading psychiatry journals and viewed by millions through her TEDx talk. She came into this field as a sceptic, trained to believe that nutrition was irrelevant to the brain, and changed her mind only when the evidence became impossible to ignore. In this conversation, Julia explains what her clinical trials actually found, and why 60 to 80 percent of people respond to a broad-spectrum approach once you move past the noise of a blinded study. We talk about why feeding the whole system beats chasing a single nutrient, what the biomarkers reveal about inflammation, methylation and the microbiome, and why the RDAs were never designed to support an optimally functioning brain. She makes the case that the recommended daily allowances we rely on were built to prevent deficiency diseases, not to help the brain thrive, and that this gap matters enormously for anyone struggling with their mental health. We also explore the bigger forces at play: depleted soils and what modern agriculture has done to the nutrient density of our food, the rise of ultra-processed food and why Julia calls it the cigarette of the twenty-first century, and the antidepressant withdrawal that so many people are never warned about. She shares her frustration with New Zealand's outdated supplement regulations, where a product can be effectively banned for containing a fraction too much of a nutrient, and a distributor can be threatened with serious penalties for selling something that genuinely works. Most of all, this is a hopeful conversation. It is about taking back control of your health through the food on your plate, understanding the real connection between what you eat and how you feel, and recognising that small, consistent changes can have a profound effect on the brain. Whether you are a parent navigating a child's behaviour, someone managing your own mental health, or simply curious about the science of nutrition and the brain, this episode will give you a new lens on what is possible. If you have ever been told that nutrition is irrelevant to your brain, this episode is for you. Resources and mentions: The Better Brain by Bonnie Kaplan and Julia Rucklidge What Your Food Ate by David Montgomery and Anne Biklé Te Puna Toiora, Mental Health and Nutrition Research Lab, University of Canterbury Biography: 09:26   Claude responded: Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research L… Professor Julia Rucklidge is a clinical psychologist at the University of Canterbury and Director of Te Puna Toiora, the Mental Health and Nutrition Research Lab. One of the world's leading researchers in nutritional psychiatry, she has spent more than two decades running placebo-controlled trials showing that broad-spectrum micronutrients can treat ADHD, depression, anxiety and stress, often as effectively as medication and without the side effects. She is co-author, with Bonnie Kaplan, of The Better Brain, and her TEDx talk on nutrition and mental health has been viewed millions of times. Based in Christchurch, New Zealand, she is on a mission to put nutrition where she argues it belongs: as a serious, evidence-based part of how we treat and prevent mental illness.
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    1 h et 8 min
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