Mifepristone used with misoprostol is the most common abortion regimen in the US. It is also a focal point of reproductive health policy and politics, with controversy over its legal status and regulation by the US Food and Drug Administration (FDA). Author G. Caleb Alexander, MD, MS, from Johns Hopkins discusses this and more with JAMA Deputy Editor Joseph S. Ross, MD, MHS.

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• The US Food and Drug Administration's Regulation of Mifepristone
• Politics, Science, and the Future of FDA Drug Regulation

Incidence rates of gastric cancer in younger individuals are on the rise and gastric cancer is the fifth-leading cause of cancer-related deaths worldwide. JAMA Review author Haeseong Park, MD, MPH, from the Dana Farber Cancer Institute, discusses this and more with JAMA Senior Editor Karen Lasser, MD, MPH.

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• Gastric Cancer

JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA Clinical Reviews podcasts in 2025.

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• Managing Adverse Effects of Obesity Medications
• Diagnosis and Management of Hypothyroidism
• Type 2 Diabetes: Diagnosis and Current Guidelines for Treatment
• Managing Adverse Effects of Incretin-Based Medications for Obesity
• Hypothyroidism
• Diagnosis and Treatment of Type 2 Diabetes in Adults
• JAMA Editors' Choice 2024: Clinical Reviews Podcasts