The definitive whole-body guide to living 100 healthy years, built on the paradigm shift now transforming medicine.

For nearly five hundred years, medicine has been working from the wrong map—treating the body as a collection of separate parts rather than a single, connected system. That model saved lives in trauma, surgery, and emergency care, but it has failed almost completely at the chronic diseases now driving the vast majority of human suffering: heart disease, diabetes, cancer, dementia, autoimmunity, and depression.

100 is the answer.

Drawing on more than three decades of clinical practice, Dr. Mark Hyman shows how finally we can see the body the way modern science has come to understand it: as a single integrated system in continuous conversation with itself. And at last, the instruments to measure that system—comprehensive biomarker testing, continuous wearable monitoring, AI-enhanced imaging and interpretation, multi-cancer-detection blood tests—have moved out of research hospitals and into the hands of ordinary people.

100 is an operating manual for that new reality. It teaches readers to know the difference between normal and optimal. To become the CEO of their own health. And to stop waiting for disease when they could be creating health.

The tools exist now. This book puts them in your hands.