Couverture de Unstoppable Brain with Dr. Kyra Bobinet

Unstoppable Brain with Dr. Kyra Bobinet

Unstoppable Brain with Dr. Kyra Bobinet

De : Kyra Bobinet
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You have the goals, the checklists, and the ambition. Yet, there is a pesky gap between the person you are and the version of yourself that you aspire to be. If you’ve ever felt like you’re fighting an invisible headwind in your health, your habits, or your career, it’s not a character flaw. It’s a brain trap.

Welcome to Unstoppable Brain, a sanctuary of clarity in an era of ruptured attention and optimization burnout. Hosted by Kyra Bobinet, MD-MPH— physician and behavior researcher, trained at Harvard, UCSF, Stanford, and CEO of Fresh Tri—this show marks the end of the "performative" era and the beginning of the Iterative Mindset.

Each week, we cool the friction of being human and empower you through stories and practical science:

• The Trend-Check: We cut through the noise of wellness fads and click-bait science. Dr. Bobinet, with her sharp-witted co-host, pressure-tests the latest trends and peer-reviewed papers, debunking the junk and translating real science into a clear, actionable roadmap for your week.
• The Master Class: We go behind the scenes interviewing world-class innovators, clinicians, and creators who have abandoned the performance trap to iterate their way through profound struggle and into lives of purpose.
• The Science of You: Drawing on Dr. Bobinet’s decades of work—from wilderness therapy with incarcerated youth to leading health innovation for 30 million people—we explore what unlocks your potential through the lens of the brain, the habenula (your brain’s master switch for all you do or feel), and how the Iterative Mindset is the ultimate protective factor against getting stuck.

Stop fighting your brain. Start leading it. Whether you are navigating a high-stakes career pivot, reclaiming your vitality, or simply looking to find your footing in an overstimulating world, Unstoppable Brain provides the hard science and relatable storytelling to help you become truly unstoppable.Forbes Books Hygiène et vie saine Médecine alternative et complémentaire Psychologie Psychologie et psychiatrie
Épisodes
  • Steve Ramirez: How Memory Shapes Grief, Addiction & Who You Are

    Steve Ramirez: How Memory Shapes Grief, Addiction & Who You Are
    Oct 21 2026
    What if your memories aren't recordings of the past, but edits you rewrite every time you recall them?

    On this episode of Unstoppable Brain, Dr. Kyra Bobinet sits down with Steve Ramirez, neuroscientist and associate professor of psychological and brain sciences at Boston University and author of How to Change a Brain. Steve is known for pioneering research on manipulating memories in the brain, which he started with his late lab partner and friend, Xu Liu.

    Steve talks openly about losing Xu at 37, the drinking that followed, and the intervention by his wife and childhood best friends that saved his life. He explains how recovery taught him that "the opposite of addiction is connection," and how building new positive memories helped him grow a life around his grief.


    They also get into the science: why every recall changes a memory a little, how psychedelic-assisted therapy may hold the memory "file" open longer for editing, what engrams are, why lost memories may still be in the brain (the library is intact, but the librarian is on strike), and how short-form content and the attention economy are affecting our memory and decisions.


    If you've been through loss, are working on changing a habit, or just want to understand how your brain builds who you are, this conversation is for you.

    What you'll learn

    • Why a single memory can move you to tears or euphoria in seconds, and affect your whole body
    • How grief works like a fixed bubble that a bigger life can grow around
    • Why Steve says the opposite of addiction is connection, and what finally helped him get sober
    • How recalling a memory is like hitting "Save As" on a Word file, and why every recall changes it
    • How psychedelic-assisted therapy may help people work with memories that are "too hot to touch"
    • The ethics of memory manipulation, from clinical healing to social media ads
    • What an engram is, and why memory works like a 3D web or a symphony instead of one spot in the brain
    • Why the brain may use memories mainly to predict the future
    • How "lost" memories in Alzheimer's, addiction and childhood amnesia have been restored in research
    • How short-form content affects attention and memory, and the "fast food" way to think about it
    • Why flawed memory is a reason to give each other more grace and curiosity in arguments


    Time Stamps

    00:30 Welcome and introduction to Dr. Steve Ramirez
    01:30 Why scientists talk in jargon
    03:00 The main message of How to Change a Brain
    04:15 Honoring Xu Liu, Steve's late lab partner
    05:00 Death as a teacher: Kyra's story of losing a friend
    06:45 We all become memories
    08:30 How Xu's legacy lives on in the science
    09:30 Using grief to help others
    10:30 Trauma, PTSD and the hippocampus
    12:45 "One plus one equals three": the partnership with Xu
    14:45 Losing Xu and the slide into drinking
    17:30 The intervention that saved his life
    18:00 Recovery Elevator and "the opposite of addiction is connection”
    19:30 COVID drinking as collective grief
    21:00 Emotion and memory: Antonio Damasio
    21:45 Growing your life around grief
    23:15 Seeing life "in 4K with sober eyes”
    24:15 Building positive memories after loss
    26:30 Therapy, language and naming feelings
    27:00 Psychedelic-assisted therapy and "too hot" memories
    29:00 Eternal Sunshine and the ethics of erasing memories
    29:30 Recalling a memory is like hitting "Save As”
    32:00 Ethical vs. manipulative uses of memory science
    33:45 Myth or fact: do memories change every time we recall them?
    36:00 Memory as the brain's best prediction
    37:45 What is an engram?
    40:15 Can you lose your sense of self without a hippocampus?
    41:45 Are we the same person over time?
    43:45 What is the "DNA of memory”?
    45:30 The library is intact, the librarian is on strike
    47:00 Backup copies of memories in the brain
    49:15 Shout-out to optogenetics and Karl Deisseroth
    50:00 Short-form content and memory
    52:15 Short-form media as "fast food”
    53:15 The attention economy, gambling and manipulation
    54:30 Being metacognitive about your scrolling
    57:15 Flawed memory, arguments and giving each other grace
    58:30 Reasons for hope and learning from each other
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    1 h et 1 min
  • Dr. Kyra Answers Your Questions About Habits, Cravings, and Change

    Dr. Kyra Answers Your Questions About Habits, Cravings, and Change
    Jul 2 2026
    Why do we know exactly what we should do, then still fail to do it?

    In this season finale of Unstoppable Brain, Dr. Kyra Bobinet answers viewer questions with special guest Isabella Allen.Together, they explore the neuroscience behind the “know-do gap,” why motivation breaks down, how the habenula acts as the brain’s behavioral brake, and why habits, addiction, procrastination, stress, and self-sabotage are all connected.

    Dr. Kyra explains why your brain may stop you from taking action, how doom scrolling and snoozing can become addictive loops, and why relying on panic and deadlines can wear you down over time. She also breaks down the surprising connection between GLP-1s, cravings, addiction, the vagus nerve, acetylcholine, genetics, trauma, and behavior change.

    This episode is a practical and science-backed Q&A for anyone who wants to understand why change feels so hard, and how to work with the brain instead of fighting it.Learn how to close the gap between what you know you should do and what you actually do.

    What You’ll Learn
    • Why there’s a gap between knowing what to do and actually doing it
    • How the habenula acts as the “brake” on behavior
    • Why your phone can hijack your morning routine
    • How stress and panic become a productivity trap
    • Why self-compassion helps the “doer” follow through
    • How the habenula helps you stop wasting effort and start iterating
    • The possible connection between GLP-1s, cravings, and addiction
    • How the vagus nerve may relate to behavior change
    • Why trauma, genetics, and environment can shape motivation
    • What Dr. Kyra learned from season one of Unstoppable Brain

    Chapters
    00:30 Intro: A Season Finale Q&A
    00:47 Why Do We Know What To Do But Still Don’t Do It?
    01:06 The Know-Do Gap Explained
    02:05 What Is the Habenula?
    03:00 Why Your Brain Hits the Brakes
    04:41 How to Stop Morning Doom Scrolling
    06:02 Why Deadlines and Panic Drive Productivity
    07:35 The Planner vs. The Doer
    08:41 How Rewards Help You Take Action
    09:49 Is There Anything Positive About the Habenula?
    10:45 What Rats Teach Us About Failure and Iteration
    12:45 GLP-1s, Addiction, and Cravings
    13:50 How GLP-1s May Quiet the Habenula
    17:13 The Vagus Nerve and the Habenula
    18:23 Acetylcholine, Calm, and Habit Change
    20:18 Are Brain Behaviors Learned or Genetic?
    21:25 Trauma, Epigenetics, and a Sensitive Habenula
    24:00 Dr. Kyra’s Biggest Takeaway From Season One
    25:16 Closing Thoughts and Season Two Tease
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    26 min
  • Marcus Buckingham: Why Love Is the Most Powerful Force in Business

    Marcus Buckingham: Why Love Is the Most Powerful Force in Business
    Jun 18 2026
    What happens when businesses start treating people like resources instead of human beings? In this episode of Unstoppable Brain, Dr. Kyra Bobinet sits down with bestselling author and performance researcher Marcus Buckingham to explore the business case for love.

    Drawing from his new book, Design Love In, Marcus explains why love is far more than a soft idea. It is a measurable force that shapes employee engagement, customer loyalty, resilience, productivity, and long-term business value.


    Marcus shares why people need “red threads” in their workday, how leaders can create stronger connections with remote teams, and why weekly check-ins can have a major impact on performance. He also examines the growing role of artificial intelligence in the workplace and asks a crucial question: Can AI help humans flourish, or are companies using it in ways that damage the customer experience?


    You’ll learn:
    • Why love is a serious business metric
    • How to identify the work that gives you energy
    • Why employees need at least 20% “red threads” in their day
    • How leaders can build connection across remote teams
    • The five feelings that create loving experiences
    • Why AI struggles to replace genuine human care
    • How to handle difficult leadership decisions with compassion


    Marcus Buckingham is a leading authority on human strengths and performance. He is the bestselling author of First, Break All the Rules, Love + Work, and Design Love In.


    Subscribe to Unstoppable Brain for more conversations that turn neuroscience into practical strategies for behavior change and a better life.

    00:00 Cold Open
    00:45 Introducing Marcus Buckingham
    02:07 Why Love Is the Most Powerful Force in Business
    05:31 Why Business Leaders Avoid the Word “Love”
    06:40 What Marcus Learned After Selling His Company
    09:40 Love Is Oxygen
    10:14 Finding Your Red Threads at Work
    12:39 How Love Changes Your Brain
    13:34 Why You Need 20% Red Threads in Your Day
    17:10 You Can’t Love What You Can’t See
    18:15 The Weekly Check-In Every Manager Should Use
    20:45 How Remote Teams Build Real Connection
    23:20 The Five Feelings That Create Love
    25:03 Control, Harmony, and Significance
    28:07 Why People Need the Warmth of Others
    29:44 Growth, Learning, and Loyalty
    34:49 What Love Really Means
    36:44 When Firing Someone Can Be an Act of Love
    39:31 Can Humans Love AI?
    42:03 Can AI Love Humans?
    43:25 Is AI Damaging the Customer Experience?
    48:27 Will AI Crush Human Connection?
    52:08 The Data Behind the Business Case for Love
    57:00 Why Business Schools Overlook Love
    58:00 Love, Motivation, and the Habenula
    01:07:00 How to Fire Someone Lovingly
    01:11:50 Final Takeaways
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    1 h et 13 min
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