Couverture de The Synthesis of Wellness®

The Synthesis of Wellness®

The Synthesis of Wellness®

De : Chloe Porter
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 Chloe Porter is dedicated to health research and optimization. She is the host of The Synthesis of Wellness ® Podcast; an engineer; and an acclaimed health science speaker, expert, and best-selling author known for her deep dives into gastrointestinal function, functional health, and health optimization.Chloe Porter Hygiène et vie saine Médecine alternative et complémentaire
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    Épisodes
    • 204. Intestinal Barrier Function, The Gut-Immune Axis, & Vitamin D3 | 1,25-dihydroxyvitamin D₃

      204. Intestinal Barrier Function, The Gut-Immune Axis, & Vitamin D3 | 1,25-dihydroxyvitamin D₃
      Jan 30 2026

      In this encore episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support intestinal health, while highlighting intestinal mucosal anatomy.


      Topics:

      1. Introduction

      - Highlighting intestinal barrier function and the gut-immune axis with a focus on vitamin D₃

      2. Vitamin D Synthesis and Metabolism

      - Skin and 7-dehydrocholesterol; dietary intake.

      - Transported through the bloodstream bound to vitamin D binding protein.

      - First hydroxylation in the liver to form 25-hydroxyvitamin D₃ (25(OH)D₃).

      - Testing.

      - Second hydroxylation in the kidney to form the active 1,25 dihydroxyvitamin D₃ (1,25(OH)₂D₃).

      - Local activation also occurs.

      3. Intestinal Barrier Anatomy

      - The intestinal epithelium forms a selectively permeable monolayer that interfaces with the gut lumen.

      - Covered by a mucus layer.

      - Tight junction proteins and paracellular permeability.

      - The lamina propria and Gut-Associated Lymphoid Tissue (GALT).

      - Maintaining tolerance.

      4. Vitamin D

      - 1,25-dihydroxyvitamin D₃, tight junction integrity, immune regulation, and more.


      5. Vitamin D₂ and D₃

      6. Conclusion - Neither too high nor too low: optimal levels.

      - Multifactorial: Numerous factors regulate vitamin D levels.

      - Gastrointestinal health root cause approach.



      Thank you to our episode sponsor:

      1. "⁠Longevity⁠" with Protein, Probiotics, Bovine Colostrum, Collagen, and More. Use code ⁠CHLOE⁠ for 25% off.


      *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



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      14 min
    • 203. The Stomach | Gastric Acid Secretion and the Role of Gastric Acid in Downstream Micronutrient Absorption

      203. The Stomach | Gastric Acid Secretion and the Role of Gastric Acid in Downstream Micronutrient Absorption
      Jan 23 2026

      In this encore episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance.


      Topics:

      1. Hypochlorhydria

      - Low stomach acid.


      2. H. pylori


      3. Gastric Anatomy & Layers

      - The stomach: hollow, muscular organ for mechanical and chemical digestion.

      - Regions: Cardia, fundus, body, and pylorus.

      - Layers: Mucosa, Submucosa, Muscularis externa, Serosa


      4. Mucosal Layer

      - Surface mucous cells secrete a thick bicarbonate-rich, protective mucus.

      - Gastric pits lead to gastric glands, which contain specialized secretory cells.


      5. Specialized Gastric Cells

      - Parietal Cells: Secrete hydrochloric acid (HCl) and intrinsic factor (IF).

      - Chief Cells: Secrete pepsinogen (converted to pepsin by HCl) and gastric lipase.

      - Role of HCl: Activates pepsin, denatures proteins, and contributes to nutrient absorption.

      - Intrinsic factor and vitamin B12 absorption.


      6. Vitamin B12 Absorption

      - Essential for DNA synthesis, RBC formation, neurological function.

      - Released from food proteins by gastric acid and pepsin.

      - Impaired absorption.


      7. Role of Gastric Acid in Broader Micronutrient Absorption

      - Absorption of minerals.

      - Soluble, ionized state.

      - Iron: HCl aids in preventing insoluble precipitates and supports iron absorption.


      8. Protective Role of Gastric Acid

      - Acts as a line of defense against ingested pathogens.

      - Maintains low microbial diversity in the stomach.

      - Low HCl and Small Intestinal Bacterial Overgrowth.


      9. Symptoms of Low Stomach Acid

      - Bloating, early satiety, excessive belching.

      - Undigested food in stool, chronic constipation.

      - May reflect impaired enzymatic activation and digestive insufficiency.


      10. Conclusion

      - Multifactorial causes and downstream effects.

      - Optimal range, neither high nor low.



      Thank you to our episode sponsor:

      1. "Longevity" with Protein, Probiotics, Bovine Colostrum, Collagen, and More. Use code CHLOE for 25% off.


      *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



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      13 min
    • 202. Intestinal Hyperpermeability & the Mucosal Barrier | Highlighting the Role of Zinc in Supporting Intestinal Barrier Function

      202. Intestinal Hyperpermeability & the Mucosal Barrier | Highlighting the Role of Zinc in Supporting Intestinal Barrier Function
      Dec 5 2025
      In this encore episode, we highlight key roles that zinc plays in supporting various aspects of mucosal barrier integrity, while detailing the structure of the intestinal mucosal barrier. We detail key anatomical features, including the mucus layer, epithelial cells, and tight junctions, before discussing zinc’s physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details mechanistic features of zinc absorption as well as specialized forms such as zinc carnosine.Topics:1. Introduction - Overview of intestinal hyperpermeability and intestinal barrier function- Highlighting the role of zinc 2. Intestinal Barrier Anatomy - Four major layers: mucosa, submucosa, muscularis externa, serosa- Mucosa subdivisions; focus on epithelium 3. The Mucus Layer - Location over the epithelial surface- Composition: mucin-rich, secreted by goblet cells- Goblet cell mucin storage and expansion upon hydration- Functions: trapping pathogens, lubricating epithelium, housing molecules including secretory IgA- Small intestine mucus - Large intestine mucus 4. The Intestinal Epithelium - Monolayer of epithelial cells: enterocytes, goblet cells, and more- Tight junctions, paracellular transport - Continuous epithelial renewal 5. Introduction to Zinc - Zinc as a trace mineral required in minute quantities for numerous physiological processes - Second most abundant trace mineral after iron; majority stored in muscle and bone- Maintaining plasma and intracellular zinc concentrations within narrow range- Both deficiency and excess can disrupt biochemical processes 6. Zinc and Copper - Zinc and copper as closely interconnected minerals- Zinc, copper, and metallothionein binding in enterocytes- Both high and low zinc can disrupt zinc-copper balance- Metallothionein as a cysteine-rich metal-binding protein 7. Factors Affecting Zinc Levels - Multifactorial- Possible signs of low zinc status 8. Zinc Absorption - Dietary sources- Primary absorption in small intestine - In the stomach: HCl and pepsin denature proteins and cleave peptide bonds, releasing zinc from protein complexes- Dietary zinc often bound within tertiary protein structure- Specialized transporters 9. Zinc’s Role in the Intestinal Barrier - Zinc and tight junction proteins- Zinc and Intestinal Epithelial Cells - Zinc and the mucus layer 10. Broader Context of Zinc in Physiology 11. Zinc Carnosine - Molecular complex of zinc and carnosine- L-carnosine composed of beta-alanine and L-histidine- Gastrointestinal context 12. Conclusion - Multifactorial and multi-system.Thank you to our episode sponsor: 1. Shop ⁠O-Liv High Phenolic Extra Virgin Olive Oil⁠ and O-Liv's ⁠Olive Oil Supplement⁠. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Thanks for tuning in!"⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
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      13 min
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