In this encore episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support intestinal health, while highlighting intestinal mucosal anatomy.

Topics:

1. Introduction

- Highlighting intestinal barrier function and the gut-immune axis with a focus on vitamin D₃

2. Vitamin D Synthesis and Metabolism

- Skin and 7-dehydrocholesterol; dietary intake.

- Transported through the bloodstream bound to vitamin D binding protein.

- First hydroxylation in the liver to form 25-hydroxyvitamin D₃ (25(OH)D₃).

- Testing.

- Second hydroxylation in the kidney to form the active 1,25 dihydroxyvitamin D₃ (1,25(OH)₂D₃).

- Local activation also occurs.

3. Intestinal Barrier Anatomy

- The intestinal epithelium forms a selectively permeable monolayer that interfaces with the gut lumen.

- Covered by a mucus layer.

- Tight junction proteins and paracellular permeability.

- The lamina propria and Gut-Associated Lymphoid Tissue (GALT).

- Maintaining tolerance.

4. Vitamin D

- 1,25-dihydroxyvitamin D₃, tight junction integrity, immune regulation, and more.

5. Vitamin D₂ and D₃

6. Conclusion - Neither too high nor too low: optimal levels.

- Multifactorial: Numerous factors regulate vitamin D levels.

- Gastrointestinal health root cause approach.

Thank you to our episode sponsor:

1. "⁠Longevity⁠" with Protein, Probiotics, Bovine Colostrum, Collagen, and More. Use code ⁠CHLOE⁠ for 25% off.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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