Every bite of food you eat is sending instructions to your genes. Right now. As we speak. Your breakfast is literally programming your DNA.

In Week 2 of our 6-week epigenetics series, Dr. Steve Presciutti reveals the revolutionary science of how nutrients act as code that reprograms your genetic expression in real-time. This isn't about calories or macros. This is about information.

What You'll Discover:

• The 5 methyl donors that determine which genes turn on and off (folate, B12, choline, methionine, B6) - and why 90% of people are deficient in at least 2-3 of them

• Why "food is fuel" is the biggest lie in nutrition - and how Dr. Mark Hyman's "food is information" framework changes everything

• The ATP-methylation connection: Why you can't optimize gene expression without optimizing cellular energy first

• Polyphenol powerhouses: How curcumin, resveratrol, quercetin, and EGCG regulate the enzymes that control your genetic expression

• Your complete epigenetic meal plan: Breakfast, lunch, and dinner protocols to rewrite your genetic code every single day

Client Transformations:

Sarah: 97.2°F → 98.4°F body temperature, TSH 6.8 → 2.1 in 6 weeks by optimizing methyl donors

Mark: CRP 8.2 → 2.1, resolved chronic inflammation and brain fog by adding polyphenol-rich foods

Jennifer: 96.8°F → 98.4°F, reversed fatigue and depression by combining energy optimization with methylation support

The Science:

Anderson et al. (2012) - DNA methylation is strongly influenced by dietary methyl donors (893 citations)

Bekdash et al. (2023) - Methyl donors modulate the epigenome and are critical for brain health (60 citations)

Lorente-Cebrián et al. (2025) - Polyphenols promote histone acetylation and gene expression activation (5 citations)

Wallace (2010) - Mitochondrial function modulates DNA methylation through ATP production (648 citations)

Lopes et al. (2020) - Mitochondria control substrates for nuclear DNA methylation (121 citations)

Rosenberger et al. (2021) - SAM levels control mitochondrial energy metabolism through protein methylation (52 citations)

The Truth:

Your genes aren't your destiny. Your gene expression is. And that's something you can control with every meal.

Food is code. And you are the programmer.

Ready to write better code?

Take the Metabolic Health Assessment at biosparkhealth.com/assessment

We'll create your personalized epigenetic nutrition protocol - specific foods, timing, and supplements based on YOUR unique biochemistry. Because you didn't come this far to only come this far.

Next Week: The 25/75 Truth - twin studies, epigenetic divergence, and scientific proof that lifestyle matters more than genetics.

This is The Metabolic Revolution. You came to the right place. Let's talk.

Everything you've been told about genetics is incomplete. Your doctor says "it's genetic" like it's a life sentence. But what if I told you that genes only control about 25% of your health outcomes? What if the other 75% is completely under your control? Today I'm going to introduce you to the science that changes everything: epigenetics.

In this episode, we dive deep into:

• The 25/75 split between genes and environment
• DNA as hardware, epigenetics as software
• How identical twins age differently
• The methylation mechanism explained simply
• Food as epigenetic information
• Methyl donors: Folate, B12, Choline, Methionine, B6
• Polyphenols as epigenetic regulators (Curcumin, Resveratrol, EGCG, Quercetin)
• The ATP-methylation connection
• Why metabolic optimization IS epigenetic optimization
• Temperature as a proxy for epigenetic health
• Three actionable steps to take THIS WEEK

Key Concepts

DNA vs Epigenetics

• DNA (Hardware): Your genetic code is fixed. You inherit half from your mother, half from your father. This sequence cannot be changed.
• Epigenetics (Software): Which genes are turned on and off. This is completely dynamic and responsive to your environment. You're upgrading or downgrading this software every single day with every meal, every sleepless night, every stressful thought.

The 25/75 Split

DNA methylation heritability ranges from only 3-20%. That means somewhere between 80-97% of your epigenetic profile is determined by NON-genetic factors: environment, lifestyle, and diet.

DNA Methylation

Your DNA has little chemical tags called methyl groups that sit on top of your genes. These methyl groups act like switches:

• Methylated gene = Turned off, silenced
• Unmethylated gene = Turned on, active

You can't change your DNA sequence, but you CAN change which genes are methylated and expressed.

Research Citations

Twin Studies & Epigenetic Differences

Fraga et al. (2005) - "Epigenetic differences arise during the lifetime of monozygotic twins" - Cited by 4,711 studies

• Young identical twins (3 years old) had nearly identical epigenetic profiles
• Older twins (50 years old) showed substantial variations in DNA methylation patterns
• 35% of twin pairs had significant epigenetic differences
• PMCID: PMC1174919

Martin GM. (2005) - "Epigenetic drift in aging identical twins" - Cited by 231 studies

• Older identical twin pairs show substantial variations in epigenetic profiles
• Young twins are essentially indistinguishable, older twins diverge significantly

Reynolds CA, et al. (2020) - "A decade of epigenetic change in aging twins" - Cited by 65 studies

• Evaluated 96 pairs of twins over a 10-year span
• DNA methylation changes are associated with aging process

Methyl Donors & DNA Methylation

Bekdash RA, et al. (2023) - "Methyl Donors, Epigenetic Alterations, and Brain Health" - Cited by 60 studies

• Micronutrients like choline, betaine, folic acid, methionine, and vitamins B6 and B12 modulate the epigenome
• Critical for brain health and development

SEASON 1 FINALE

The companion episode that proves grandmother's kitchen was a biochemistry lab. Sarah Chen and Marcus Thompson deliver the research that validates ancestral wisdom.

This Deep Dive is the culmination of 25 episodes of myth-busting. Every traditional practice dismissed as "old-fashioned" is validated by modern science. The researchers who said our grandmothers were wrong? They were the ones who didn't understand biology.

The Research That Changes Everything:

Weston A. Price's global studies in the 1930s and 40s documented remarkable health in traditional populations across vastly different cultures. Swiss mountain communities, Scottish islanders, Native Americans, Pacific Islanders, African tribes. The specific foods varied, but patterns remained constant: nutrient-dense animal foods, traditional fats, organ meats, bone broths. Within 1 to 2 generations of adopting modern processed foods, dental arches narrowed, chronic disease emerged, and fertility declined.

Epigenetic Evidence:

The Dutch Hunger Winter studies (1944-45) provide compelling evidence for metabolic programming. Children who were in utero during the famine showed higher rates of obesity, cardiovascular disease, and metabolic disorders as adults. Even more remarkably, these effects transmitted to the next generation. Grandchildren of women pregnant during the famine showed increased health risks despite never experiencing famine themselves. Your grandmother's nutrition during pregnancy influenced YOUR metabolism.

Studies and Research Cited:

Dutch Hunger Winter transgenerational studies showing metabolic programming effects lasting 2+ generations. Weston A. Price's "Nutrition and Physical Degeneration" documenting traditional vs. modernized population health outcomes. Research on traditional Polynesian populations showing superior thyroid markers in groups eating coconut-based diets versus those using modern seed oils. Studies showing breakfast consumption associated with better metabolic outcomes and body composition. Ray Peat's work on saturated fat's ability to support thyroid function versus PUFA suppression.

Key Mechanisms Explained:

Why traditional fats (lard, butter, tallow, coconut oil) support metabolism while seed oils suppress it. How the three-meal pattern aligns with circadian cortisol rhythms. Why nose-to-tail eating provides the glycine-methionine balance modern diets lack. The importance of organ meats as nature's multivitamin. Why food preparation methods (soaking, cooking, fermenting) developed over centuries for good biochemical reasons.

Practical Implementation:

Sarah and Marcus provide clear action steps for returning to traditional wisdom: eliminating seed oils, incorporating organ meats and bone broth, eating three consistent meals, simplifying food choices, and cooking vegetables properly.

Your Next Step:

For those ready to implement traditional wisdom with expert guidance, the Bioenergetic Reset Program at Biospark Health provides the complete framework. Six weeks of coaching, community, and customized protocols designed around the principles your grandmother knew instinctively. Visit biosparkhealth.com.

The Integration:

Everything in 25 episodes, every protocol, every principle, your grandmother did naturally. Not because she read studies. Because she trusted traditions passed down through generations. Those traditions were right. Science finally caught up.

Your cells are waiting. Trust the wisdom. Trust your body.

See you in Season 2.