Welcome to episode 34 of the Performance Around the Clock. In this episode, host Dr. Satchin Panda, welcomes his esteemed colleague, Dr. Pamela Maher from the Salk Institute for Biological Studies. Dr. Maher is a rare scientist who has taken drug discovery from basic science findings in cells all the way to compounds being tested in human clinical trials. In this episode, they discuss her journey through research on cell membranes and signaling, leading to her pivotal work on cell death pathways like oxytosis and ferroptosis. The conversation also covers the development of potential therapeutics for aging and Alzheimer's disease, including compounds like J147 and CMS-121, and the exploration of cannabinoids for neuroprotection. If you like this episode, please like, comment or follow. Thank you for listening.

Guest:

Dr. Pamela Maher

Research Professor at the Salk Institute

Cellular Neurobiology Laboratory

Profile:

https://www.salk.edu/scientist/pamela-maher/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to the Performance Around the Clock podcast. In this episode, Dr. Satchin Panda welcomes one of his scientific heroes, Dr. Susan Golden. Dr. Golden is a pillar in the circadian and cyanobacteria science community and the former director for the Center for Circadian Biology at UC San Diego. She shares her journey from studying gene regulation in cyanobacteria to understanding the circadian clock through this unique organism. Learn how these ancient blue-green algae were instrumental in the oxygenation of Earth's atmosphere and how tools developed to study cyanobacteria led to groundbreaking discoveries. Beyond her research, Dr. Golden also made significant contributions to circadian rhythm education, teaching countless undergraduate students over the years. If you like this episode, please like, comment or subscribe. Thank you for listening.

Guest:

Dr. Susan Golden

Director, Center for Circadian Biology

Chancellor's Associates Chair (III) in Molecular Biology

Distinguished Professor

X (Twitter): @susanksgolden

https://x.com/susanksgolden

Profile:

UCSD:

https://biology.ucsd.edu/research/faculty/sgolden

Wikipedia:

https://en.wikipedia.org/wiki/Susan_Golden

Paper:

Circadian orchestration of gene expression in cyanobacteria

https://pubmed.ncbi.nlm.nih.gov/7601351/

Thanks to 理philosophia onlineについて for the photo of Dr. Takao Kondo

https://www.philosophia.sci.nagoya-u.ac.jp/snapshots/44.html

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In our last episode from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are honored to host Dr. John Newman and Dr. Brianna Stubbs, both experts in ketone metabolism and aging. Dr. Newman is a geriatrician and researcher at the Buck Institute for Research on Aging and in the Division of Geriatrics at UCSF. His research focuses on how ketone bodies, small molecules that our bodies make for energy during fasting or exercise, also work as molecular signals to control inflammation and gene expression. Dr. Brianna Stubbs is an expert in exogenous ketone metabolism and the Director of Translational Science at the Buck Institute for Research on Aging. She's a former competitive rower and two-time world champion, and she completed her PhD in metabolic physiology at the University of Oxford, where she studied the metabolic effects of ketone esters. Learn all about their work translating ketone research into the field. If you like this episode or podcast, please like, comment or follow. Thank you for listening.

Guests:

Dr. John Newman

Division of Geriatrics at UCSF

Assistant Professor Buck Institute for Research on Aging

X (Twitter): @geriscidoc

https://x.com/geriscidoc

Profile:

Division of Geriatrics at UCSF

https://profiles.ucsf.edu/john.newman

https://medicine.ucsf.edu/people/john-newman

Buck Institute for Research on Aging

https://www.buckinstitute.org/lab/newman-lab/

Dr. Brianna Stubbs

Director of Translational Science at Buck Institute for Research on Aging

X (Twitter): @briannastubbs

https://x.com/briannastubbs

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/
More science: https://mycircadianclock.org/