Main Topic
In this episode of Oncology Unscripted, Dr. John Marshall explores how new approaches are shaping cancer treatment decisions, from using AI to help personalize treatment for individual patients to the unexpected results of a randomized trial of adagrasib in colorectal cancer. He also examines how precision medicine may help guide treatment for patients with cancers of unknown primary.

MedBuzz
In this MedBuzz, Dr John Marshall examines the rising cost of cancer treatments and the difficult questions surrounding the value of innovation including the nearly $40,000 monthly price of daraxonrasib, and the broader challenge of balancing medical advances with access to care.

Interview
In this Candid Conversation, John Marshall, MD, and Derek Raghavan, MD, PhD, discuss the business of cancer care, including treatment costs, value, financial toxicity, incentives in oncology, and the importance of honest conversations about the benefits and burdens of treatment.

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Main Topic
In this episode of Oncology Unscripted, Dr John Marshall reflects on growing vaccine hesitancy and contrasts that with new reports that a personalized melanoma messenger RNA vaccine improved outcomes in a phase 3 study.

MedBuzz
In this MedBuzz, Dr John Marshall reflects on recent changes in prescription drug pricing and the rapid rise of GLP-1 receptor agonists, their long-term impacts, and how he handles answers to questions from patients about impacts on cancer outcomes.

Interview
In this episode of Oncology Unscripted, John Marshall, MD, speaks with evolutionary biologist Daniel E. Lieberman, PhD, author of Fed Up, about the connections between physical activity, nutrition, the microbiome, and cancer prevention.

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Main Topic
In this episode of Oncology Unscripted, Dr Marshall examines the evolving role of blood-based cancer screening and highlights new research showing how dogs may help detect early cancers from breath samples.

Alternative Data Centers, Medicine, and AI Guilt?
In MedBuzz, Dr Marshall discusses the emergence of betting on clinical trial outcomes, the rise of AI in medicine, the environmental impact of data centers, and whether growing reliance on artificial intelligence should leave clinicians with a sense of AI guilt.

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Main Topic:
In this episode of Oncology Unscripted, Dr John Marshall discusses major post-ASCO developments in GI oncology, including new RAS inhibitor data in pancreatic cancer and the path forward.

MedBuzz:
In this episode of Oncology Unscripted, Dr John Marshall reflects on a trip to South Africa and what it revealed about survival, inequity, and the luxury of modern cancer care. Through experiences in Johannesburg and on safari, he connects cancer care access to broader questions of privilege, community, and responsibility.

Interview:
In this episode of Oncology Unscripted, Dr John Marshall speaks with global oncology experts about cancer care access and the barriers that limit availability of new treatments and testing worldwide. The discussion examines drug pricing, reimbursement, value, and the need for more equitable access to cancer care.

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MedBuzz:
In this episode of Oncology Unscripted, John Marshall, MD, discusses a troubling week in health care news, including upheaval at the FDA, concerns about reduced federal support for medical education, and growing evidence that AI-generated fabricated references are appearing in published scientific literature.

Main Topic:
In this episode of Oncology Unscripted, Dr John Marshall previews the practice-changing data expected at ASCO 2026, highlighting advances in precision medicine. Tune in to hear which presentations could shape the next wave of cancer care.

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MedBuzz:
In this episode of Oncology Unscripted MedBuzz, Dr Marshall discusses evolving rectal cancer data and the growing role of genomic testing. He also reflects on US science policy and concerns about instability, and the need to modernize clinical trials while protecting independent oversight and patient data.

Main Topic:
In this episode of Oncology Unscripted, Dr Marshall discusses the growing role of precision medicine in oncology and how it is shifting from an optional tool to a standard part of cancer care, including the increasing importance of MRD and ctDNA, and promise of blood-based cancer screening.

Interview:
In this episode of Candid Conversations , Dr. John Marshall speaks with Dr. Marija Balic of UPMC and the University of Pittsburgh about MRD ctDNA testing in early breast cancer.

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MedBuzz:
In this MedBuzz, Dr John Marshall discusses Steve Ubl’s departure from PhRMA and what it may signal for drug pricing, pharmaceutical policy, payer dynamics, and patient access.

Main Topic:
In this episode of Oncology Unscripted, Dr John Marshall explores the growing role of AI in cancer care, from analyzing patient data and predicting treatment responses to supporting clinical trials, guidelines, manuscripts, and patient communication. He also reflects on the risks of AI, including privacy, bias, accountability, energy demands, and the potential loss of human connection in medicine.

Interview:
In this expert panel discussion of Oncology Unscripted, Dr John Marshall explores how artificial intelligence is being used in health care today and where it may be headed next. Guests Neel Trivedi, MD; Ross Filice, MD; and Torbjørn Furuseth, MD, discuss AI scribes, radiology, digital pathology, clinical decision-making, patient privacy, and the ongoing role of human judgment in medicine.

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MedBuzz:
After a trip to the Galapagos, Dr John Marshall reflects on evolution in nature, cancer, and medicine. From Darwin’s observations to the rise of AI and precision oncology, he explores how rapidly cancer adapts, how technology is reshaping care, and why the future of medicine must still preserve the human touch.

Main Topic:
In this episode of Oncology Unscripted, Dr John Marshall reflects on a practice-changing cholangiocarcinoma study from China and what it reveals about the rapid evolution of cancer research worldwide. As novel therapies transform care and China expands its investment in science while the US devests, he asks whether we can keep pace and the impacts of the global evolution of in oncology.

Interview:
Watch now as Dr John Marshall sits down with Dr Louis Weiner, director of Georgetown University’s Lombardi Cancer Center, for a candid conversation about leadership, scientific change, and the future of oncology. Reflecting on innovation, institutional transition, and the pressures reshaping cancer research, they explore what it means to evolve as a leader and honoring the work and the people.

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