The vampire and Rougarou threat is no more, but an even more powerful enemy has placed the world in peril. An alien force, led by the she-devil Spearfinger, has staked a claim on planet Earth while Spearfinger plots to conquer the universe. Spearfinger plots to retrieve two ancient relics that would enable her to unleash Hell literally. Only a fellow fallen angel named JD can have any hope of stopping her.

Mad Dog and Brad embark on a journey from Washington, DC, to Tennessee, but the alien invasion and the lingering undead make the trip far from safe. Mad Dog and Brad lead a convoy out of the city when they are captured by the Draconians. Will the two seasoned Marines escape the enemy's clutches or end up on a dinner menu?

Buford and Rue join a team of humans and cryptids for a suicide mission to destroy the Draconian mothership. Little does Rue know there is something about the plan that doesn’t add up. The team isn’t happy about the two last-minute additions, but at least they are good in a fight. Will the team be successful, or will they all perish to the horrors inside the ship? The worst of which is the infamous Bear Baron, but with major upgrades.

Penny becomes the de facto leader of the human and Sasquatch survivors when Spearfinger and her Draconian subordinates pay a visit. The town of Stillwater comes under siege by a superior armed enemy when Spearfinger retrieves one of the relics. Will Spearfinger succeed in her evil plan, or will the good citizens of Townsend and Stillwater stop her and the reptilian invaders?