In the spring of 1974, Calliope Stephanides, a student at a girls' school in Grosse Pointe, finds herself drawn to a chain-smoking, strawberry-blonde classmate with a gift for acting. The passion that furtively develops between them - along with Callie's failure to develop physically - leads Callie to suspect that she is not like other girls. In fact, she is not really a girl at all.

The explanation for this shocking state of affairs is a rare genetic mutation - and a guilty secret - that have followed Callie's grandparents from the crumbling Ottoman Empire to Prohibition-era Detroit and beyond, outlasting the glory days of the Motor City, the race riots of 1967, and the family's second migration, into the foreign country known as suburbia. Thanks to the gene, Callie is part girl, part boy. And even though the gene's epic travels have ended, her own odyssey has only begun.

Spanning eight decades - and one unusually awkward adolescence - Jeffrey Eugenides' long-awaited second novel is a grand, original fable of crossed bloodlines, the intricacies of gender, and the deep, untidy promptings of desire.

Winner of the 2003 Pulitzer Prize for Fiction and the Audie Award for best unabridged fiction, Middlesex marks the fulfillment of a huge talent, named one of America's best young novelists by both Granta and The New Yorker.