They’re broke, bitter, and not ready to give up without a fight.

Three middle-aged women who have seen their carefully crafted lives take a precipitous financial plunge, forge an unlikely friendship while getting paid to take part in a clinical trial for a new menopause drug. The trio spends a month sequestered at a pharmaceutical testing facility that has all the charm of a nail salon inside a Walmart, and bond over their anger and disbelief that their only hope for some quick cash is leveraging the remaining estrogen they have lurking in their ovaries.

Each of these women has a recent story of their existence hurtling to hell. Maria had a career catastrophe so epic that googling her name is now painful. Cassie’s extreme vanity took an ugly turn, and Julie’s husband didn’t just walk out on their marriage, he disappeared with all the money.

Once they become roommates, this cadre of unlikely friends merge their talents to find Julie’s missing husband and her half of the “marital assets”. Maria has major accounting mojo, Julie has connections, and Cassie, a former soap opera actress, has acquired an assortment of shady skills during her Hollywood tenure.

As they plot, scheme, and embark on an adventure to find an AWOL spouse, they learn how to fight back against a world they believe deems them old and insignificant and, in the process, discover that 50 is when life gets fun, especially when you can get even.