Couverture de GABA Explained: Anxiety, Benzodiazepines, Sleep, and Withdrawal — PMHNP Board Review

GABA Explained: Anxiety, Benzodiazepines, Sleep, and Withdrawal — PMHNP Board Review

GABA Explained: Anxiety, Benzodiazepines, Sleep, and Withdrawal — PMHNP Board Review

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 Gamma-aminobutyric acid, commonly known as GABA, is the brain’s principal inhibitory neurotransmitter and plays an important role in anxiety, sleep, neuronal excitability, and seizure regulation. In this episode of PMHNP in the Car, we examine GABA-A and GABA-B receptors, explain how benzodiazepines enhance inhibitory signaling, and compare commonly prescribed medications including lorazepam, alprazolam, clonazepam, and diazepam. We also explore medication half-lives, adverse effects, dependence, withdrawal syndromes, and the potentially life-threatening consequences of abruptly discontinuing long-term benzodiazepine treatment. Through clinical examples and PMHNP board-style questions, listeners will learn how to connect GABA neurobiology with safe psychiatric prescribing and clinical decision-making.
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