There are two kinds of clinicians—the ones who follow algorithms, and the ones who understand the “why.”

Patients know the difference. Know the WHY!

Join our clinical library today on PATREON!

👉 https://www.patreon.com/PearlsandPrep

What about Saphris (asenapine)?

In this episode of Pearls & Prep, we break down one of the more overlooked second-generation antipsychotics and explore where asenapine may fit in the treatment of bipolar I disorder, acute mania, mixed episodes, and schizophrenia.

We’ll cover why Saphris is given sublingually, what makes its receptor profile unusual, and how its strong dopamine D2, serotonin 5-HT2A/5-HT2C, histamine H1, and adrenergic activity translates into clinical practice.

We’ll also tackle an important bipolar pearl: Saphris can be used for bipolar I maintenance even though it is not an established treatment for acute bipolar depression.

You'll learn:

• Who may be a good candidate for Saphris

• When you might choose asenapine for acute mania or mixed symptoms

• Why Saphris must dissolve under the tongue

• Why mouth numbness and altered taste occur

• How Saphris affects sleep and sedation

• Weight and metabolic considerations

• Why its low muscarinic activity matters

• How 5-HT2A, 5-HT2C, H1, D2 and α-adrenergic receptors matter clinically

• The surprising pharmacologic similarities—and major differences—between Saphris and Remeron

• When Saphris may NOT be the antipsychotic you want

Perfect for PMHNP students, psychiatric nurse practitioners, psychiatry residents, prescribers, and clinicians studying psychopharmacology, bipolar disorder, schizophrenia, antipsychotics, or psychiatric medications.

Key medications discussed: Saphris (asenapine), Zyprexa (olanzapine), Seroquel (quetiapine), Abilify (aripiprazole), Remeron (mirtazapine), risperidone, and paliperidone.

Pearls & Prep — your preceptor in your pocket.

36

Saphris Made Easy: Why Choose Asenapine Over Other Antipsychotics?

Pearls and Prep

pearlsandprep@mail.com

https://patreon.com/PearlsandPrep?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink