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Your Brain On

Your Brain On

De : Drs. Ayesha and Dean Sherzai
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 A podcast about the neuroscience of everything. From neurologists, researchers, and public health advocates Drs. Ayesha and Dean Sherzai, explore every aspect of our world through a neuroscientific lens, with science-based stories, interviews, anecdotes, and brain health facts. Equip yourself with neurologically sound answers to life's everyday health questions and learn the essentials of brain health and optimization, one topic at a time.2024 Hygiène et vie saine Science
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    Épisodes
    • Your Brain On... Cold Plunges

      Your Brain On... Cold Plunges
      Jan 21 2026
      Cold plunges are everywhere, and the way people talk about them, you'd think they're a miracle cure for your brain, body, and soul. But in an age of algorithm-fueled evangelism, when a ritual becomes this ubiquitous and loud, we have to ask: how much of the buzz is backed by science… and how much is just marketing? In this episode, we explore the neuroscience of cold exposure: what's real, what's overstated, and why this "discomfort" has become a billion-dollar industry. We discuss: Why cold plunges went viral, and how wellness movements often devolve into identity-driven culturesThe difference between cold exposure itself and the monetized "cold plunge movement"What constitutes a "cult" (and how pseudoscience forms around partial truths)The real physiological cold shock responseWhy the mental "high" after a plunge doesn't automatically equal long-term brain benefitThe cardiovascular risks that rarely get discussed, especially for people with underlying heart diseaseWhat the research suggests about soreness, pain reduction, and muscle growth (including why cold immersion can blunt hypertrophy)The real story behind brown fatWho should avoid cold plunges altogether (asthma, arrhythmias, coronary disease, vascular conditions) Joining us for this conversation is investigative journalist and bestselling author Scott Carney (What Doesn't Kill Us, The Wedge), who has spent years inside the cold exposure world, first as a skeptic, then as a believer, and eventually as a critic of the culture that formed around it. His work reveals what happens when discomfort becomes identity, and when unfounded "social media science" outruns real science. Your Brain On... is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai. SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: neuroworldretreat.com Your Brain On... Cold Plunges • SEASON 6 • EPISODE 7 REFERENCES Cold Water Immersion, Muscle Adaptation, and Recovery Roberts, L. A., Raastad, T., Markworth, J. F., Figueiredo, V. C., Egner, I. M., Shield, A., Cameron-Smith, D., Coombes, J. S., & Peake, J. M. (2015). Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training. Journal of Physiology, 593(18), 4285–4301. https://doi.org/10.1113/JP270570 Bleakley, C. M., McDonough, S. M., & MacAuley, D. C. (2004). The use of ice in the treatment of acute soft-tissue injury: A systematic review of randomized controlled trials. American Journal of Sports Medicine, 32(1), 251–261. https://doi.org/10.1177/0363546503260757 Leeder, J., Gissane, C., van Someren, K., Gregson, W., & Howatson, G. (2012). Cold water immersion and recovery from strenuous exercise: A meta-analysis. British Journal of Sports Medicine, 46(4), 233–240. https://doi.org/10.1136/bjsports-2011-090061 White, G. E., & Wells, G. D. (2013). Cold-water immersion and other forms of cryotherapy: Physiological changes potentially affecting recovery from high-intensity exercise. Sports Medicine, 43(8), 695–706. https://doi.org/10.1007/s40279-013-0055-8 Kellmann, M., Bertollo, M., Bosquet, L., Brink, M., Coutts, A. J., Duffield, R., Erlacher, D., Halson, S. L., Hecksteden, A., Heidari, J., Kölling, S., Meyer, T., Mujika, I., Robazza, C., Skorski, S., Venter, R., & Beckmann, J. (2018). Recovery and performance in sport: Consensus statement. International Journal of Sports Physiology and Performance, 13(2), 240–245. https://doi.org/10.1123/ijspp.2017-0759 Inflammation, Pain, and Perceived Recovery Hohenauer, E., Taeymans, J., Baeyens, J. P., Clarys, P., & Clijsen, R. (2015). The effect of post-exercise cryotherapy on recovery characteristics: A systematic review and meta-analysis. PLoS ONE, 10(9), e0139028. https://doi.org/10.1371/journal.pone.0139028 Costello, J. T., Culligan, K., Selfe, J., & Donnelly, A. E. (2012). Muscle, skin and core temperature after –110°C cold air and 8°C water treatment. PLoS ONE, 7(11), e48190. https://doi.org/10.1371/journal.pone.0048190 Brown Adipose Tissue (BAT) – Human Imaging & Metabolism van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. (2009). Cold-activated brown adipose tissue in healthy men. New England Journal of Medicine, 360(15), 1500–1508. https://doi.org/10.1056/NEJMoa0808718 Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N. J., Enerbäck, S., & Nuutila, P. (2009). Functional brown adipose tissue in healthy adults. New England Journal of Medicine, 360(15), 1518–1525. https://doi.org/10.1056/NEJMoa0808949 Betz, M. J., & Enerbäck, S. (2015). Human brown adipose tissue: What we have learned so far. Diabetes, 64(7), 2352–2360. https://doi.org/10.2337/db15-0146 Autonomic Nervous System, HRV, and Cold Exposure Mourot...
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      47 min
    • Your Brain On... Cheese

      Your Brain On... Cheese
      Jan 14 2026

      Around the start of 2026, a study sparked viral headlines claiming that cheese could reduce dementia risk.

      But... nutrition science almost never works like this. One study can't "prove" a food is protective or harmful, and viral health claims often miss the most important details of research: how the data was gathered, what was actually measured, what variables were controlled for, and what it means in real life.

      In this episode, we unpack what the 'viral cheese study' (PMID: 41406402) actually found, what it DOESN'T mean, and why critical thinking around nutrition headlines matters more than ever.

      We discuss:

      • Why viral food headlines are so persuasive (and so often misleading)

      • What the cheese study REALLY reported

      • The difference between correlation and causation in nutrition research

      • Why long-term dietary recall data can be unreliable

      • How bias (including our personal food preferences) shapes interpretation of research

      • What "show me the data" really means in a world of clickbait science

      • How to interpret food and brain health studies without falling into extremes

      We also speak to Emily Sonestedt, research group leader and associate professor at Lund University, and one of the authors of the viral study.

      "Your Brain On..." is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai.

      SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/

      'Your Brain On... Cheese' • SEASON 6 • EPISODE 6

      ———

      LINKS

      The study, 'High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence From a 25-Year Prospective Cohort Study': https://pubmed.ncbi.nlm.nih.gov/41406402/

      ———

      FOLLOW US

      Join NEURO World: https://neuro.world/

      Instagram: https://www.instagram.com/thebraindocs

      YouTube: https://www.youtube.com/thebraindocs

      More info and episodes: TheBrainDocs.com/Podcast
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      43 min
    • Your Brain On... Chemotherapy

      Your Brain On... Chemotherapy
      Dec 4 2025

      Chemotherapy saves lives. But for millions, it also comes with side effects of cognitive fog, memory lapses, slowed thinking, and emotional flattening.

      In the past, 'chemo brain' has sometimes been dismissed as anecdotal. But, as science has evolved, we've come to understand the very real shifts in attention, memory, processing speed, and emotional regulation underpinning the impairment.

      In this episode, we break down what's happening in the brain during treatment, why these changes arise, and how healthier lifestyle choices can support our recovery.

      In this episode, we explore:

      • What 'chemo brain' really is (and why chemotherapy itself isn't the only thing contributing to it)
      • How inflammation, hormonal shifts, anesthesia, sleep disruption, and chronic stress impact cognition during cancer
      • The latest research on structural and functional brain changes during treatment
      • Why many cognitive effects are temporary (and how neuroplasticity supports recovery)
      • How cognitive fog intersects with identity loss and grief
      • The role of nutrition in supporting clarity, energy, memory, and mood during chemotherapy
      • How to navigate food fears, misinformation, and "miracle cancer diets"
      • The importance of gentle movement, sleep consistency, and stress management
      • How patients can advocate for themselves (including tips on what to discuss with their care team)

      Bringing their perspectives and expertise to this episode are two wonderful guests:

      • DR. LIZ O'RIORDAN: retired breast surgeon, author, and three-time breast cancer survivor, whose personal and clinical experience offers a rare, deeply human insight into cancer-related cognitive change.
      • NICHOLE ANDREWS, RDN: oncology dietitian, educator, and advocate for evidence-based, fear-free nutrition during and after cancer treatment.

      "Your Brain On..." is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai.

      SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/

      'Your Brain On... Parkinson's' • SEASON 6 • EPISODE 5

      ———

      LINKS

      Dr. Liz O'Riordan:
      Website: https://liz.oriordan.co.uk/
      Instagram: https://www.instagram.com/oriordanliz/
      YouTube: https://www.youtube.com/channel/UC_t0jGeR8M4vCPSb68itjRQ

      Nichole Andrews, RDN:
      Website: https://theoncologydietitian.com/
      Instagram: https://www.instagram.com/oncology.nutrition.rd/

      ———

      FOLLOW US

      Join NEURO World: https://neuro.world/
      Instagram: https://www.instagram.com/thebraindocs
      YouTube: https://www.youtube.com/thebraindocs
      More info and episodes: TheBrainDocs.com/Podcast

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      42 min
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