In this episode of The Feldman Protocol, a provocative question anchors the conversation: how much of cardiovascular risk is about cholesterol itself versus the context it operates in? Guest **Josh Wageman, DPT, PA-C, PhD**—a clinical lipid specialist and researcher—makes the case for using metaphor, metabolic health, and imaging to think differently about risk. The discussion spans coronary calcium scoring, lipid particles, insulin and inflammation, endurance training extremes, neurodegeneration, and why communicating science clearly actually matters. 🔥 This episode is sponsored by us -- Own Your Labs `http://ownyourlabs.com` -- private blood testing services.🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters3:00 – Why metaphors matter in medicine9:32 – Josh’s unconventional training path15:48 – Overtraining, illness, and collapse21:56 – Thyroid failure and recovery28:10 – Learning endocrinology the hard way34:42 – From PT to lipid specialist41:05 – Why lipids became the focus47:22 – Humor as a teaching tool53:40 – Writing the “lipid neighborhood”1:00:02 – Four pillars of metabolic health1:06:18 – Insulin and context over numbers1:12:35 – Inflammation isn’t one thing1:18:52 – Drugs as a risk factor1:25:14 – Cholesterol doesn’t live on paper1:31:28 – CAC as a reality check1:37:44 – Zero CAC and residual risk1:43:59 – Genetics vs lifestyle1:50:12 – ApoB’s necessary role1:56:27 – Why plaque still forms2:02:41 – Extreme endurance and CAC2:08:55 – When fitness backfires2:15:10 – Imaging vs biomarkers2:21:26 – Dementia and lipid biology2:27:40 – Neurodegeneration as frontier2:33:55 – Teaching clinicians differently2:40:08 – Credentials vs trust2:46:22 – Patient-first frameworks2:52:36 – Science communication failures2:58:49 – Measuring what matters3:04:55 – Meaning beyond metrics3:11:10 – Legacy and patient impact3:15:42 – Where Josh wants research to go3:18:43 – Closing thoughts and gratitude#FeldmanProtocol #DaveFeldman #JoshWageman #Lipids #Cholesterol #MetabolicHealth #ApoB #CACScore #Endocrinology #PreventiveCardiology #HealthCommunication

In this episode of The Feldman Protocol, Dave asks: what happens when a fertility specialist-turned-health thinker questions nutrition narrative? Guest Robert Kiltz, MD, makes the case for animal-based diets, metabolic flexibility, mindset, faith and medicine, clinical experience vs. guidelines, and the role of community. The conversation ranges from physiology and lipid metabolism to entrepreneurship, skepticism, and personal practice — always with an eye toward evidence and open inquiry.

🔥 This episode is sponsored by us -- Own Your Labs http://ownyourlabs.com -- private blood testing services.
🩸Over 300 blood tests
💰Extremely affordable
❤️ We love our customers
(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:
Main Channel: https://youtube.com/@realDaveFeldman
X/Twitter: https://x.com/realDaveFeldman
Instagram: https://instagram.com/realDaveFeldman
Website: https://thefeldmanprotocol.com

⏱ Chapters
3:00 – Opening themes & big questions
6:38 – Robert’s clinical background
10:17 – Nutrition beliefs under the microscope
13:55 – Defining metabolic health
17:34 – Mindset, faith, and medicine
21:12 – Carnivore experiences & context
24:51 – LDL, risk, and interpretation
28:29 – Citizen science in practice
32:08 – Physiology vs. guidelines
35:46 – The liver’s central role
39:25 – Energy substrates explored
43:03 – Food, behavior, and culture
46:42 – Clinical anecdotes & caution
50:20 – Lipids and metabolism debate
53:59 – Diet, hormones, and stress
57:37 – Weight, appetite, & satiety
1:01:16 – Exercise, fitness, longevity
1:04:54 – Medical orthodoxy pressures
1:08:33 – Risk-benefit & uncertainty
1:12:11 – Lab markers & context
1:15:50 – Entrepreneurship & medicine
1:19:28 – Patient communication style
1:23:07 – Spirituality & health lens
1:26:45 – Preventive care realities
1:30:24 – Evidence vs. experience
1:34:02 – Personal responsibility
1:37:41 – Critics & open inquiry
1:41:19 – Careers, courage, & change
1:44:58 – Community & service
1:48:36 – Learning from disagreement
1:52:15 – Practical takeaways
1:55:53 – Health as a journey
1:59:32 – Gratitude & perspective
2:03:10 – Final reflections
2:06:49 – Closing thoughts & thanks

#FeldmanProtocol #DaveFeldman #RobertKiltz #podcast #nutrition #healthjourney #openinquiry #metabolism #lowcarbcommunity #wellnessdiscussion #citizenscience #medicalethics #mindsetmatters #healthydebate #scienceconversation

In this episode of The Feldman Protocol, Dave asks a blunt question: is modern medicine structurally aligned against prevention? Guest **Emily Kaplan**, investigative science journalist and co-founder of the Broken Science Initiative, makes the case that incentives, not evidence, increasingly shape medical practice. They discuss conflicts of interest in research, the reproducibility crisis, metabolic health and lifestyle medicine, GLP-1 drugs, nutrition education gaps, and why outcomes often matter less than headlines.🔥 This episode is sponsored by us -- Own Your Labs `http://ownyourlabs.com` -- private blood testing services.🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters3:01 – Broken Science explained6:02 – Lifestyle vs polypharmacy9:03 – Medical school nutrition gaps12:13 – Incentives in healthcare15:57 – Sugar and cancer framing18:36 – Trial endpoints questioned21:11 – GLP-1s and tradeoffs24:01 – Weight loss vs health26:21 – Personal choice in diet29:02 – Early insulin signals32:25 – Publishing and paywalls35:10 – Journalism vs academia38:42 – Conflicts of interest42:08 – Peer review problems45:44 – Delays in publication49:12 – Who funds research52:48 – Education as prevention56:19 – Reproducibility crisis59:01 – Replication failures1:02:28 – Meta-analysis limits1:05:30 – Industry influence1:08:54 – What gets taught1:12:40 – Transparency gaps1:16:33 – Accountability in science1:38:20 – Where reform starts1:40:14 – Transparency vs incentives1:52:38 – Publishing power dynamics2:05:11 – Peer review bottlenecks2:17:44 – Conflicts without disclosure2:30:06 – Career risk in dissent2:42:31 – Nutrition sidelined again2:54:57 – Prevention vs treatment3:00:14 – N-of-1 data debate3:12:48 – Prospective study limits3:25:22 – Community-driven research3:37:49 – IRB and self-selection3:50:17 – Data ownership questions4:02:41 – Tech platforms for science4:10:06 – Scaling transparency4:15:32 – Reforming research norms4:18:54 – Public accountability4:20:41 – Communicating uncertainty4:22:53 – Where to find Emily4:23:05 – Final reflections#FeldmanProtocol #DaveFeldman #EmilyKaplan #BrokenScience #MedicalResearch #ScienceJournalism #MetabolicHealth #NutritionEducation #HealthcareIncentives #ReproducibilityCrisis #PreventiveMedicine #PublicHealth

In this episode of The Feldman Protocol, a central question hangs over the conversation: what actually causes a heart attack when standard risk markers look “normal”? Guest Dr. Stephen Hussey, DC (functional medicine practitioner focused on cardiovascular disease), makes the case for re-examining core assumptions about heart disease. Topics include plaque vs. risk, LDL cholesterol, CAC scoring, stress physiology, hydration, type 1 diabetes, endurance exercise, and alternative mechanisms behind myocardial infarction.

🔥 This episode is sponsored by us -- Own Your Labs [http://ownyourlabs.com](http://ownyourlabs.com) -- private blood testing services.

🩸Over 300 blood tests

💰Extremely affordable

❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: https://youtube.com/@realDaveFeldman

X/Twitter: https://x.com/realDaveFeldman

Instagram: https://instagram.com/realDaveFeldman

Website: https://thefeldmanprotocol.com

⏱ Chapters

3:06 – Why heart cells don’t regenerate

8:12 – Marathon runners & plaque paradox

13:48 – Introducing Dr. Stephen Hussey

18:37 – Type 1 diabetes & heart risk

23:54 – Diet changes and inflammation

29:35 – Low-carb, keto, and carnivore paths

35:10 – Insulin, carbs, and standard care

40:52 – Fear of ketosis vs ketoacidosis

46:18 – Discovering lipid anomalies

51:40 – Rejecting statins early on

57:12 – Elevated LDL in context

1:02:44 – Writing a heart disease book

1:08:30 – Widowmaker heart attack story

1:14:06 – CAC score of zero explained

1:19:42 – Stress, dehydration, and triggers

1:25:18 – The moment symptoms began

1:30:54 – Cath lab and LAD blockage

1:36:20 – Stent placement and relief

1:41:58 – Was it plaque or clot?

1:47:30 – Alternative MI mechanisms

1:53:12 – Parasympathetic nervous system

1:58:54 – Vasa vasorum hypothesis

2:04:36 – Transcytosis and ApoB

2:10:18 – Endothelial injury models

2:15:44 – Exercise-linked occlusions

2:21:06 – Post-MI medical advice

2:26:30 – Five lifelong medications?

2:31:48 – Blood pressure overshoot

2:37:22 – Blood thinners and stents

2:42:54 – Re-evaluating cholesterol blame

2:48:10 – What medicine gets wrong

2:53:36 – Prevention beyond LDL

2:58:52 – How Stephen works with clients

#FeldmanProtocol #DaveFeldman #StephenHussey #HeartHealth #Cardiology #MetabolicHealth #Cholesterol #LDL #Atherosclerosis #CACScore #Type1Diabetes #ExerciseScience

In this episode of The Feldman Protocol, we ask: What happens when clinical guidelines collides with messy real-world outcomes? Guest Bret Scher, MD, makes the case for rethinking metabolic health, evidence hierarchies, clinical incentives, LDL interpretation, ketogenic therapies, guideline rigidity, psychiatric applications of metabolic interventions, and his own evolution from cardiologist to medical director in the metabolic-health space.🔥 This episode is sponsored by us -- Own Your Labs http://ownyourlabs.com -- private blood testing services.🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: https://youtube.com/@realDaveFeldmanX/Twitter: https://x.com/realDaveFeldmanInstagram: https://instagram.com/realDaveFeldmanWebsite: https://thefeldmanprotocol.com⏱ Chapters3:00 – How clinicians lose objectivity13:57 – When lifestyle advice keeps failing24:55 – The social cost of challenging LDL norms35:52 – Epidemiology’s limits in nutrition46:50 – Why “healthy user bias” distorts data57:47 – The Diet Doctor era and its impact1:08:45 – Red meat, risk, and uncertain evidence1:19:42 – Predicting outcomes vs. assuming causality1:30:40 – The guidelines problem inside medicine1:41:37 – Why patients succeed outside the system1:52:35 – Multiple dietary paths, not one dogma2:03:32 – How personality shapes dietary fit2:14:30 – From keto diet to medical therapy2:25:27 – The mindset shift toward low carb2:36:25 – How podcasting changed Bret’s trajectory2:47:22 – The origin story of Metabolic Mind2:58:20 – Metabolic psychiatry’s scientific emergence3:09:17 – Coalition for Metabolic Health vision#FeldmanProtocol #DaveFeldman #BretScher #MetabolicHealth #Keto #LowCarb #Cardiology #EvidenceBased #NutritionScience #LDL #Epidemiology #CriticalThinking #MetabolicPsychiatry #HealthPolicy #MedicalGuidelines #Wellness #MetabolicMind #Podcast #ScienceDiscussion

In this episode of The Feldman Protocol, what if a single overlooked nutrient could meaningfully alter how we think about chronic illness? Guest Dr. Darren Schmidt (DC, nutrition-focused clinician) makes the case for the role of B1 deficiency, discusses environmental toxic exposures, explores mitochondrial dysfunction, and examines lactic acidosis as a framework for understanding complex disease patterns. We also discuss metabolic pathways, autonomic issues, and how clinical observations can challenge conventional assumptions.

🔥 This episode is sponsored by us -- Own Your Labs http://ownyourlabs.com -- private blood testing services.
🩸Over 300 blood tests
💰Extremely affordable
❤️ We love our customers
(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:
Main Channel: https://youtube.com/@realDaveFeldman
X/Twitter: https://x.com/realDaveFeldman
Instagram: https://instagram.com/realDaveFeldman
Website: https://thefeldmanprotocol.com

⏱ Chapters
3:00 – Early health shifts
4:58 – First exposure incident
6:56 – Discovering toxicity impacts
8:54 – Mold and respiratory effects
10:52 – Gas leak symptoms escalate
12:50 – ER visit and missed signals
14:48 – Autonomic dysfunction clues
16:46 – Testing high-dose B1
18:44 – Rapid symptom relief
20:42 – Mechanisms Dave examines
22:40 – High-calorie malnutrition idea
24:38 – Clinical responses to B1
26:36 – RCT possibilities
28:34 – Origins of lactic acidosis theory
30:32 – How toxins affect oxygen use
32:30 – Capillary dilation mechanics
34:28 – Mitochondrial parallels
36:26 – Detox strategies overview
38:24 – Dave’s metabolic framework
40:22 – Pyruvate and lactate shifts
42:20 – Rate limiters in metabolism
44:18 – Nervous system involvement
46:16 – Expanding symptom categories
48:14 – Environmental drivers of illness
50:12 – Mold detection and evidence
52:10 – Radon and other exposures
54:08 – Chronic illness complexity
56:06 – Personal learning through crises
58:04 – Rediscovering past medical history
1:00:02 – Nutrient fortification lessons

#FeldmanProtocol #DaveFeldman #DarrenSchmidt #metabolism #mitochondria #chronicillness #environmentalhealth #nutritionscience #lactate #thiamine #functionalhealth #biochemistry #healthpodcast #keto #lowcarb #detox #mitochondrialfunction

In this episode of The Feldman Protocol, can you truly build muscle and maintain health with just 15 minutes of exercise twice a week? Dave chats with Ben Bocchicchio, PhD in Exercise Physiology and Health, who makes the case for slow-motion resistance training as the ultimate efficiency hack. Guest explores mitochondrial optimization through high-intensity exercise, addresses middle-age workout mistakes, discusses low-carb nutrition strategies spanning five decades, and challenges conventional fitness wisdom with his revolutionary "safe emergency" training philosophy.🔵 This episode is sponsored by US -- Own Your Labs http://ownyourlabs.com -- private blood testing services.- 🩸Over 300 blood tests- 💰Extremely affordable- ❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support and keep advertisements limited, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: https://youtube.com/@realDaveFeldmanX/Twitter: https://x.com/realDaveFeldmanInstagram: https://instagram.com/realDaveFeldmanWebsite: https://thefeldmanprotocol.com⏱ Chapters3:14 – Introduction and athletic background12:37 – Uncle Tony and Charles Atlas connection25:42 – Nautilus machines and slow training origins40:18 – Muscle fiber recruitment and intensity58:23 – Common middle-age exercise mistakes1:15:47 – Metabolic benefits of resistance training1:32:19 – Nutrition philosophy and 50-year approach1:50:33 – Food addiction and behavioral change2:08:56 – AI and personalized health predictions2:22:41 – Energy metabolism and final thoughts#FeldmanProtocol #DaveFeldman #BenBocchicchio #SlowTraining #ResistanceTraining #ExercisePhysiology #Mitochondria #LowCarb #Nutrition #MetabolicHealth #HighIntensityTraining #Fitness #Aging #Sarcopenia #HealthSpan #Longevity #BloodTesting #Science

In this episode of The Feldman Protocol, special guest Mike Mutzel explores groundbreaking research on the immune system, GLP-1, the gut microbiome and lean mass hyper-responders. They deep dive on the Lipid Energy Model, atherosclerosis mechanisms, immune system interactions, coronary artery imaging data, and conventional cardiovascular risk paradigms in metabolic health.

🔥 This episode is sponsored by us -- Own Your Labs http://ownyourlabs.com -- private blood testing services.

🩸Over 300 blood tests

💰 Extremely affordable

❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: https://youtube.com/@realDaveFeldman

X/Twitter: https://x.com/realDaveFeldman

Instagram: https://instagram.com/realDaveFeldman

Website: https://thefeldmanprotocol.com

⏱ Chapters

3:01 – Introduction and Mike's background

9:14 – Medicine and nutrition evolution

17:44 – Mindful eating and GLP-1 connections

25:00 – Dave's cholesterol discovery story

31:42 – Understanding lipid trafficking physics

40:18 – Endothelial dysfunction and inflammation

49:00 – LDL oxidation and modification theories

58:23 – Atherosclerosis as immune response

1:05:47 – Blood viscosity and cardiovascular risk

1:15:19 – Self-censorship in scientific discourse

1:25:33 – Continual exposure hypothesis debate

1:32:19 – Own Your Labs citizen science project

1:40:58 – Cholesterol paradox in aging populations

1:50:33 – Metabolic health vs inflammation

2:00:12 – Radiation concerns with CT angiograms

2:08:56 – Triglycerides and ketogenic metabolism

2:18:47 – Study results and mainstream response

2:22:41 – Final thoughts and future research

#FeldmanProtocol #DaveFeldman #DaveFeldmanGuest #LipidEnergyModel #LeanMassHyperResponder #LMHR #CholesterolResearch #MetabolicHealth #LDLCholesterol #CoronaryArteryImaging #ApoB #CardiovascularHealth #KetoResearch #CitizenScience #OwnYourLabs #LipidParticles #Atherosclerosis #EndothelialFunction #BloodViscosity #TriglyceridesTolerance #LPA