Melissa was healthy, had no worrisome symptoms, and never expected cancer to become part of her story. But after making the Galleri multi-cancer early detection (MCED) test part of her health routine, her second annual test returned a Cancer Signal Detected result with a predicted origin of liver/bile ducts.

On this episode of The Cancer SIGNAL podcast, Melissa shares what happened next, including the diagnostic journey that would confirm her Stage IA cancer diagnosis.

Melissa also reflects on the role her family played throughout treatment and recovery, and why her experience has strengthened her commitment to proactive health and early detection.

Transcripts: https://grail.com/podcast/

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The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests.

See Important Safety Information: https://www.galleri.com/safety-information

Host Rayshawnda Madison connects with Roger, a returning guest who first shared his story in 2023 after receiving a Cancer Signal Detected result from the Galleri multi-cancer early detection (MCED) test. Follow-up testing led to a stage II pancreatic cancer diagnosis.

Now, three years later, Roger reflects on how life has evolved since completing treatment, what survivorship looks like for him today, and the mindset that helped him move forward. He also shares how the experience changed his relationship with health, why he remains vigilant, and what motivates him to continue raising awareness about MCED testing.

The overall sensitivity in study participants with pancreas cancer was 83.7%. (61.9% for stage I, 60.0% stage II, 85.7% stage III, 95.9% stage IV).

The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests.

Transcripts: https://grail.com/podcast/

Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/

See Important Safety Information: https://www.galleri.com/safety-information

In this episode, Robert, a carpenter from the Midlands in England and a participant in the NHS-Galleri trial, joins host Shawnda Madison to share his experience.

After enrolling in the trial, Robert received a Cancer Signal Detected result from the Galleri multi-cancer early detection (MCED) test despite having no symptoms. The initial diagnostic evaluation did not identify cancer, but a subsequent Galleri test the following year returned the same result, leading his care team to continue investigating.

Eventually, a biopsy revealed a small HPV-related cancer at the base of his tongue. Robert reflects on the uncertainty of waiting for answers, the treatment and recovery that followed, and how the experience changed the way he thinks about health, screening, and the value of finding cancer earlier.

Transcripts: https://grail.com/podcast/

Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/

The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests.

See Important Safety Information: https://www.galleri.com/safety-information

The overall sensitivity in study participants with head and neck cancer was 85.7% (63.2% for stage I, 82.4% stage II, 84.2% stage III, 96.0% stage IV).

Based on a clinical study of people ages 50 to 79, around 1% are expected to receive a Cancer Signal Detected result. After diagnostic evaluation, around 40% of these people are expected to have a confirmed cancer diagnosis.