Season 1 of The 5 Minute Signal: Health & Longevity is finalized. Performance Research Expert Aris Sterling conducts a high-level audit of the twenty biological signals sent so far—from the implementation of Digital Twins and Predictive Health Avatars to the data-backed reality of Epigenetic Resets and OSK-mediated reprogramming. This is not a cessation of broadcast; it is a tactical maintenance window for your biological infrastructure. This episode serves as a manifesto for empirical integrity, outlining why this show relies exclusively on peer-reviewed research and reliable sourcing to reject the "wellness" fiction dominating the industry. We move beyond "bio-hacking" into the territory of biological engineering. As we prepare for the Season 2 relaunch on February 1st, Sterling delivers the "Hard Truth" about "Baseline Drift"—the dangerous physiological decay that occurs when the monitoring stops. Most individuals lose their gains in the gaps because they rely on hope; we rely on actionable facts. This hiatus is your true test of autonomy. While the signal goes dark for a research cycle, your body remains a 24/7 data stream requiring constant management of systemic inflammation and metabolic health. We analyze the shift from Season 1’s focus on biological age tracking to Season 2’s upcoming "Interventional Escalation." This description serves as your final warning before we enter deeper protocols involving aggressive metabolic resets. Audit your circle, share the signal with those who value reality over rhetoric, and ensure your hardware is ready for the February upgrade. Stay sharp.

Citations:

• Topol, E. (2025). "Deep Medicine: How AI Makes Healthcare Human." Basic Books.

• Sinclair, D. A. (2026). "The Information Theory of Aging." Journal of Rejuvenation Research.

• Lander, E. S. (2025). "Data Integrity in Genomics." NEJM.

In this episode of The 5 Minute Signal, Performance Research Expert Aris Sterling breaks down the monumental shift from slowing aging to active cellular restoration. We move beyond the passive "Information Theory of Aging" into the 2026 reality of OSK-mediated reprogramming. For decades, the medical establishment viewed aging as a one-way street of decay; today, we analyze the biological "factory reset" protocols currently entering human clinical trials. Sterling dissects why your epigenome is not your destiny, but a software code that can be re-written—provided you have the grit to maintain the hardware. This is a deep dive into the end of inevitability and the beginning of biological autonomy.

Citations:

• Sinclair, D. A. (2026). "Epigenetic Information Recovery in Human Dermal and Vascular Tissue." Journal of Molecular Rejuvenation.

• Takahashi, K., & Yamanaka, S. (2025). "The Scaling of OSK Factors in Clinical Longevity Interventions." Nature Biotechnology.

In this episode of The 5 Minute Signal, Performance Research Expert Aris Sterling dismantles the traditional reactive model of cardiology. As of January 2026, the medical landscape has shifted with the implementation of new CPT codes for AI-driven plaque characterization, yet most individuals are still relying on antiquated stress tests that only detect disease once it's nearly too late. Sterling explores the biological reality of "soft plaque," the limitations of traditional diagnostic gatekeeping, and how AI-enabled Coronary Computed Tomography Angiography (CCTA) is transforming heart attack prevention from a game of chance into a precision science. We move beyond the "clogged pipe" analogy to understand the inflammatory profile of the arterial wall and why your "normal" stress test might be the most dangerous document in your medical file.

Citations:

1. Journal of the American College of Cardiology (JACC), "AI-Enabled Plaque Quantification and Major Adverse Cardiovascular Events," 2025.

2. Centers for Medicare & Medicaid Services (CMS), "Reimbursement Policy for Category I CPT Code 75577," effective January 1, 2026.

3. The CONFIRM2 International Registry, "Predictive Accuracy of AI-QCT in Non-Obstructive Coronary Artery Disease," presented at AHA 2025.