Dr. Kevin Perez is a computational biologist working at the cutting edge of aging science and drug discovery. His work focuses on aging research, drug repurposing, and integrating complex multi-omics data to better understand how we can extend healthspan.

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Timestamps:

00:00 Intro

00:47 Kevin’s study about pharmaceuticals that are associated with reduced mortality

10:17 Which class of drugs had reduced mortality

13:07 Bon Charge sponsorship

14:12 How Kevin researches longevity molecules

16:37 Estrogen’s longevity effects

17:37 How Kevin started researching dog aging

25:32 Chemical reprogramming

29:32 Kevin’s understanding of what causes aging

34:52 Metformin vs SGLT2 inhibitors

38:37 Erectile dysfunction drugs

43:02 Over the counter supplements with longevity effects

45:52 Biological age clocks

50:02 What Kevin thinks is the best biomarker of aging

54:32 Composite biological age vs combination of multiple markers

59:32 Kevin’s new study plans

01:02:52 What Kevin wishes he adopted sooner

Start rewinding your biological clock: https://www.siimland.co/course

P.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

Join our LONGEVITY Community: https://www.skool.com/longevity-society

Timestamps:

00:00 Intro

00:37 Why Brad crowd funded a rapamycin trial

03:22 What Brad’s rapamycin trial found

12:57 Why rapamycin blunted the effects

17:17 Rapamycin effects on grip strength

19:57 Rapamycin and immune effects

21:47 Effects on biomarkers

25:22 Brad’s thoughts on rapamycin moving forward

31:52 Metformin exercise effects

32:52 Other medicines with longevity potential

36:37 Medicines that move the needle the most for people

45:17 Will Brad do another study

48:27 Brad on GLP-1s

Dr Brad Stanfield is a family medicine doctor in New Zealand: https://www.youtube.com/@DrBradStanfield

Bloodwork for longevity panel discussion: https://youtu.be/7QONBQCpRJ0

My 2026 longevity routine: https://youtu.be/OceysodInIo

Start rewinding your biological clock: https://www.siimland.co/course

Dr. Greg Potter has a PhD from the University of Leeds in sleep, nutrition, and metabolism.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

00:45 Catchup

02:05 Are circadian rhythms nature or nurture

09:55 What’s ideal timing of sunlight exposure for circadian anchoring

15:25 Bon Charge sponsorship

20:30 Does creatine increase DHEA or DHT levels

25:50 Does creatine reduce sleep quality

33:25 Greg’s new podcast

36:15 Is more REM sleep better

42:05 How to optimize REM sleep

44:25 What % of different sleep cycles should we get (light, deep, REM)

46:10 Is food processing good or bad

52:45 Incline bed therapy

55:20 Is it bad to use sleep herbs

58:45 Does melatonin supplementation stop natural production

01:01:15 What to do if you wake up at night and can’t fall back asleep

Greg Potter YouTube Channel: https://www.youtube.com/@gregpotterphd