Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-489

Overview: Join us as we discuss lipoprotein(a) testing—including when it adds value and when it may not. We review the evidence behind this increasingly requested cardiovascular risk marker, equipping you with the knowledge to counsel patients, understand current and emerging treatment options, and optimize evidence-based strategies to reduce overall cardiovascular disease risk.

Episode resource links:

• Eur J Clin Invest. 2025 Oct 3:e70127. doi: 10.1111/eci.70127.

• Arterioscler Thromb Vasc Biol. 2022 Jan;42(1):e48-e60. doi: 10.1161/ATV.0000000000000147 Progress in Cardiovascular Diseases, 84, 2024, Pages 27-33, https://doi.org/10.1016/j.pcad.2024.05.007

Guest: Jillian Joseph, MPAS, PA-C Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-488

Overview: Stimulants have long been used to treat attention-deficit/hyperactivity disorder (ADHD); however, their mechanisms of action have been unclear. In this episode, we review a study on functional MRI to assess brain function in patients with ADHD, providing insight into the effects of stimulant medications.

Episode resource links:

• https://doi.org/10.1016/j.cell.2025.11.039

Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-487

Overview: With online access driving a dramatic surge in gambling addiction, primary care clinicians are increasingly positioned on the front lines of identification and intervention. This episode brings you practical screening tools, evidence-based treatment strategies, and prevention approaches to confidently address gambling disorder in your patients.

Episode resource links:

• Yeola A, Allen MR, Desai N, et al. Growing Health Concern Regarding Gambling Addiction in the Age of Sportsbooks. JAMA Intern Med. 2025;185(4):382–389. doi:10.1001/jamainternmed.2024.8193

• Moreira D, Azeredo A, Dias P. Risk Factors for Gambling Disorder: A Systematic Review. J Gambl Stud. 2023;39(2):483-511. doi:10.1007/s10899-023-10195-1

• Ioannidis K, Del Giovane C, Tzagarakis C, et al. Pharmacological management of gambling disorder: A systematic review and network meta-analysis. Compr Psychiatry. 2025;137:152566. doi:10.1016/j.comppsych.2024.152566

• Ulisse, K., Albitar, J., Aromin, J. T., & Berry, J. (2025). Emerging Interventions in Behavioral Addictions: A Narrative Review of Psychedelics and Neuromodulation. Brain sciences, 15(9), 980. https://doi.org/10.3390/brainsci15090980

• Identifying a gambling disorder: Mass.gov Practice Guidelines for Treating Gambling-Related Problems. Includes brief screening, Assessment, Diagnosis, Hotlines and Resources.

• Gambling Addiction Calendar: Free app

• Reset App: Free

Guest: Jill M. Terrien PhD, ANP-BC Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-486

Overview: Optimizing diabetes management starts with choosing the right medication for the patient. Listen in as we discuss current prescribing recommendations, empowering you to confidently compare medication classes and select therapies that best fit individual patient needs—while prioritizing kidney protection to reduce the risk of long-term complications.

Episode resource links:

• Jensen SK, Heide-Jørgensen U, Andersen IT, et al. SGLT2 Inhibitors vs GLP-1 Receptor Agonists for Kidney Outcomes in Individuals With Type 2 Diabetes. JAMA Intern Med. Published online January 20, 2026. doi:10.1001/jamainternmed.2025.7409
• Samson SL, et al. American Association of Clinical Endocrinology consensus statement: comprehensive type 2 diabetes management algorithm—2023 update. Endocr Pract. 2023;29(5):305-340.

Guest: Jillian Joseph, MPAS, PA-C Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-485

Overview: Teenagers are at higher susceptibility for hearing loss and often engage in behaviors that greatly increase their risk of permanent damage. In this episode, we look at current prevalence data and the pathophysiology of adolescent hearing loss, providing practical, office-ready prevention strategies to identify at-risk teens and intervene early.

Episode resource links:

• Reijers SNH, Vroegop JL, Paping DE, Pronk M, Goedegebure A, Kremer B, van der Schroeff MP. Longitudinal Insights into Sensorineural and Noise-Induced Hearing Loss in Adolescents Aged 13-18 Years. Otolaryngol Head Neck Surg. 2025 Dec;173(6):1385-1392. doi: 10.1002/ohn.70042. Epub 2025 Oct 14

• Byeon H. Associations between adolescents' earphone usage in noisy environments, hearing loss, and self-reported hearing problems in a nationally representative sample of South Korean middle and high school students. Medicine (Baltimore). 2021 Jan 22;100(3):e24056. doi: 10.1097/MD.0000000000024056.

Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-484

Overview: Muscle growth, tissue repair, sexual function—compounded injectable peptides are marketed online for an expanding list of uses, and they’re showing up in your patients’ medicine cabinets. Join us as we explore this growing trend, evaluate the evidence behind the claims, and discuss how to counsel patients on potential safety risks.

Episode resource links:

• Expert Opin Drug Saf. 2026 Mar;25(3):581-588. doi: 10.1080/14740338.2025.2499670 HSS J. 2025 Jul 31;21(4):15563316251355551. doi: 10.1177/15563316251355551 JAMA 2017;318;(20):2004-2010. doi:10.1001/jama.2017.17069

Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-483

Overview: Human papilloma virus (HPV) vaccination can prevent most cases of cervical cancers, yet global coverage remains critically low. In this episode, we discuss the latest evidence on single-dose vs. two-dose HPV vaccination regimens, empowering you to counsel patients and families with confidence, address barriers to series completion, and maximize cancer prevention in your adolescent population.

Episode resource links:

• Noninferiority of One HPV Vaccine to Tow Doses. The New England Journal of Medicine. 2025. Kreimer AR, Porras C, Liu D, et al.
• Cancer Prevention and Early Detection Facts and Figures. American Cancer Society (2025). 2025. Rick, Alteri, Deana Baptiste, Emily Butler Bell, et al.

Guest: Anne Powell, MD Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-482

Overview: In this episode, we discuss how stress—specifically cumulative stress—exposure throughout a lifetime can contribute to negative health concerns and outcomes. While stress impacts everyone, its effects highlight racial disparities in mortality between Black and White adults. Listen in as we discuss evidence on how structural factors shape health outcomes and how we can address stress-related disease burdens in clinical practice.

Guest: Mariyan L. Montaque, DNP, FNP-BC Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.