Understanding another layer of the DIGIN model to potential root causes of chronic disease- intestinal permeability. This episode discusses:

• gut barrier function
• factors that influence intestinal permeability that may lead to chronic inflammation and disease - IBD, leaky gut, and more
• current assessment and testing techniques, including specific biomarkers
• how we can regulate the gut barrier with diet, prebiotics, and probiotics
• proposed dietary factors/interventions to support the gut barrier

References:

• Camilleri M. (2019). Leaky gut: mechanisms, measurement and clinical implications in humans. Gut, 68(8), 1516–1526. https://doi.org/10.1136/gutjnl-2019-318427
• Yu, S., Sun, Y., Shao, X., Zhou, Y., Yu, Y., Kuai, X., & Zhou, C. (2022). Leaky Gut in IBD: Intestinal Barrier-Gut Microbiota Interaction. Journal of microbiology and biotechnology, 32(7), 825–834. https://doi.org/10.4014/jmb.2203.03022
• Schoultz, I., & Keita, Å. V. (2020). The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability. Cells, 9(8), 1909. https://doi.org/10.3390/cells9081909
• Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J. D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014). Intestinal permeability--a new target for disease prevention and therapy. BMC gastroenterology, 14, 189. https://doi.org/10.1186/s12876-014-0189-7