Saloni Dattani, author of the Scientific Discovery Substack and founding editor of Works in Progress magazine, joins Infinite Loops to discuss why medical innovation is often much slower than it needs to be.

We explore why so much research still begins in animal models, how poor data distorts our understanding of disease, why clinical trials are one of the biggest bottlenecks in medicine, and how better systems could help promising treatments reach patients faster.

Important Links:

Read more from Saloni here: https://worksinprogress.co/our-authors/saloni-dattani

And here: https://substack.com/@salonium

And listen to Saloni's podcast "Hard Drugs" here: https://harddrugs.worksinprogress.co/

Why has America become so bad at building housing, infrastructure, and major projects?

Brian Potter, author of The Origins of Efficiency and writer of Construction Physics, explains why prefab housing keeps failing and why there are no easy fixes to America's building problem. We discuss Katerra, California's anti-growth turn, and the deeper logic behind local opposition to growth: concentrated harms and diffuse benefits.

Important Links:

Read Brian's newsletter Construction Physics here: https://www.construction-physics.com/

Read Brian's book The Origins of Efficiency here: https://press.stripe.com/origins-of-efficiency

Learn more about Brian here: https://ifp.org/author/brian-potter

What can Aristotle, Plato, Prometheus, and the Greek city-states teach us about AI, innovation, and the future of human flourishing?

Alex Petkas joins the show to explore how old myths still matter in a world shaped by technology. We talk about Prometheus as the foundational myth of tech, Plato's fear that writing would become a tool for forgetting, the real lesson of Icarus, why decentralization creates cultural power, and what it means to remain fully human in the age of AI.

Important Links:

Learn More about The Cost of Glory: www.costofglory.com

Check out Alex's Youtube Channel: https://www.youtube.com/@costofglory

Alex's Twitter: https://x.com/costofglory

The Cost of Glory Substack: https://costofglory.substack.com/

Johnathan Bi returns to Infinite Loops for a conversation about founders, delusion, America, religion, mysticism, and the strange tension between truth and action.

We explore why some of the most effective builders may be the least introspective, why societies often run on useful fictions, how America encourages megalomania, what happens when materialism starts to feel incomplete, and why the "seeker" may matter even more in the age of AI. The episode moves from Plato and Caesar to founders, mystics, near-death experiences, and the future of human creativity.

Important Links:

Johnathan's Youtube Channel: https://www.youtube.com/@bi.johnathan

Johnathan's Substack: https://substack.com/@johnathanbi

Polina Pompliano studies some of the most successful people in the world—and what she's found challenges how we think about success, creativity, and human behavior.

In this episode of Infinite Loops, we explore the mental models behind high performers, why we misunderstand people (including ourselves), and what it really takes to see the world differently. From creativity and rationality to identity, media bias, and the hidden motivations driving success, this conversation is a deep dive into how great thinkers actually operate.

Important Links:

Check out Polina's new book:

https://www.amazon.com/Hidden-Genius-Thinking-Successful-People/dp/0593715604

More from Polina Pompliano — The Profile: https://theprofile.substack.com

In this episode of Infinite Loops, we speak with Adam Mastroianni—experimental psychologist and sharp critic of modern culture and science. We ask, why does creativity feel like it's fading?

From endless remakes to cultural sameness, Adam argues that as society becomes more stable and risk-averse, we may be unintentionally reducing the "deviance" that drives originality and breakthrough thinking. We also discuss why science should get weirder, how to fight credentialism, and the dangers of professionalization.

Important Links:

To learn more about Adam Mastroianni: https://www.adammastroianni.com/

Adam's Piece on the Decline of Deviance: https://www.experimental-history.com/p/the-decline-of-deviance

Slime Mold Time Mold: https://slimemoldtimemold.com/

Our Conversation with Julian Gough: https://newsletter.osv.llc/p/the-egg-and-the-rock-ep-249