Speaker-Organized Summary: Key Points, Decisions, and Next Steps

Announcer Lucas

Welcome to Sunday Science, where recent scientific articles and their translation into modern lives are discussed.

The host for today's episode is Dr. Brent W. Lartz, M.D.

Dr. Brent Laartz

Summary of Key Points and Decisions

The discussion focuses on a gene and gene product called Clotho, which was discovered in 1997 and is named after the Greek god of fate and destiny.

Knockout mice with Clotho upregulation showed a 15-30% longer lifespan and improved cardiovascular, renal, and brain health, as well as lower rates of cognitive decline.

However, a recent study published in the Journals of Gerontology in 2025 found a U-shaped relationship between Clotho levels and all-cause mortality.

The study showed that both high and low levels of Clotho were associated with increased mortality, and this was linked to increased liver fibrosis.

Next Steps

Further research is needed to fully understand the relationship between Clotho levels and health outcomes.

Multiple studies on Clotho have been published in the past year, and more are expected in the next one to two years.

The speaker encourages the audience to follow the podcast on various platforms to stay updated on the latest developments in longevity and science.