Épisodes

  • Jensen Out at Nvidia, Anthropic's Record IPO & the Three Ds of Competing With AI
    Nov 13 2026
    Marcus and Vic open on a week that refused to calm down. They start with the Treasury selloff, stubborn inflation, and rising jobless claims, then run through the deal flow: J&J-backed Delix's $100M raise for a non-hallucinatory psychedelic, Calley Means on Joe Rogan and why psychedelics face so little lobbying resistance, Neurosterix's schizophrenia trial and Oura's $625M purchase of Counsel Health. On policy, they cover CMS's 340B and site-neutral cuts, the 2027 physician pay cut, the FDA pausing its priority voucher pilot and the coming PBM transparency mandates, plus what Democrats might realistically roll back from HR 1. Health systems brace for Medicaid work rules, ER patients wait 24 hours in hallways and providers start suing employers over out-of-network bills. In pharma, Pfizer and Blackstone place a $1.5B GLP-1 bet as the FDA adds a vision-loss warning, alongside new prostate screening guidance for men turning 50 and a $270M bank-backed stablecoin. The back half turns to AI: Jensen Huang's resignation from Nvidia, whether tech companies are outgrowing nation-states, Anthropic's record IPO, and how founders can stay below the frontier labs' ambition threshold using Vic's three Ds of data, distribution, and downside, before closing on Google's Gemini for Healthcare. With insights into market trends, policy changes, and technological innovations shaping the future of health and money.Chapters0:00 Introduction: a week that would not calm down1:42 Treasury selloff accelerates as rate-hike pressure builds ↳https://www.wsj.com/economy/central-banking/treasury-yields-rise-as-fed-rate-hike-expectations-remain-strong-401fed892:26 Stubborn inflation and a longer Fed tightening campaign ↳https://www.axios.com/2026/11/12/inflation-rates-fed-iran-tariffs3:50 Jobless claims rise more than expected ↳https://www.wsj.com/economy/jobs/u-s-jobless-claims-rise-more-than-expected-in-the-week-c1651a1c4:22 J&J-backed Delix raises $100M for a non-hallucinatory psychedelic ↳https://www.fiercebiotech.com/biotech/delix-drums-100m-its-non-hallucinatory-psychedelic-therapy-depression4:43 Calley Means, Joe Rogan and the MAHA lobbying debate7:09 Why psychedelics face little lobbying resistance7:51 Neurosterix raises $105M for a phase 2 schizophrenia trial ↳https://www.fiercebiotech.com/biotech/addex-spinout-neurosterix-raises-105m-series-b-fund-phase-2-schizophrenia-trial8:25 Oura acquires Counsel Health for $625M ↳https://www.healthcaredive.com/news/oura-makes-bet-on-ai-in-healthcare-with-625m-counsel-health-buy/874401/9:41 Medicare cuts 340B and expands site-neutral payments ↳https://www.healthcaredive.com/news/medicare-will-cut-billions-from-340b-expand-site-neutral-payments-in-2027/873846/11:07 What Democrats could roll back: work requirements and ACA subsidies12:31 Medicare finalizes a 2.3% physician pay cut for 2027 ↳https://www.healthcaredive.com/news/medicare-finalizes-physician-pay-cut-for-2027/873862/13:32 FDA pauses its national priority voucher pilot ↳https://www.fiercebiotech.com/pharma/fda-appears-pause-controversial-speedy-review-program-complete-response-letter-disclosures14:29 PBMs face new transparency mandates ↳https://www.modernhealthcare.com/insurance/mh-pbm-transparency-rules-cvs-optum-cigna16:14 Hospitals brace for Medicaid work rules and funding cuts ↳https://www.nytimes.com/2026/11/11/business/hospitals-medicaid-cuts.html17:25 ER crowding: 24 hours in the hallway ↳https://www.wsj.com/health/healthcare/hospitals-are-so-crowded-patients-spend-24-hours-in-the-e-r-hallways-b9fe2e4d18:43 Providers start suing employers over out-of-network bills ↳https://www.statnews.com/2026/11/11/no-surprises-act-phi-health-air-ambulance-sues-employers/20:48 Pfizer and Blackstone's $1.5B GLP-1 bet ↳https://www.wsj.com/health/pharma/pfizer-signs-1-5-billion-deal-with-blackstone-to-fund-weight-loss-drug-development-b6b08b5d21:32 FDA warns of a rare vision-loss risk on GLP-1s ↳https://www.wsj.com/health/pharma/u-s-regulators-warn-glp-1-drugs-carry-possible-rare-blindness-risk-c36a456422:49 Turning 50: new prostate screening guidance ↳https://www.wsj.com/health/turning-50-prostate-screenings-arent-optional-anymore-cancer-society-says-412f5e2c23:49 Big banks commit $270M to the Project Faro stablecoin ↳https://www.coindesk.com/business/2026/11/10/goldman-sachs-citi-among-banks-said-to-commit-usd270-million-to-stablecoin-venture25:31 Jensen Huang resigns as Nvidia CEO ↳https://www.axios.com/2026/11/12/nvidia-jensen-huang-out29:30 What Nvidia looks like without its founder31:18 Are tech companies outgrowing nation states?32:36 Can you replace a founder? Nvidia vs. Apple after Jobs35:03 Anthropic seeks a record $88.5B in its IPO ↳https://news.crunchbase.com/ai/anthropic-record-ipo-ant-public-market-debut-spcx/37:06 Staying below the frontier labs' ambition threshold39:30 Unreleased models and the push into drug discovery41:09 Vic's three Ds: data, distribution and downside43:55 Google ...
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    46 min
  • 214 - The Blue Tsunami: What the Midterm Rout Means for Healthcare
    Nov 6 2026

    In this special election episode, Marcus and Vic set aside the usual news rundown to unpack a week that changed the political landscape. They start with CVS's plan to split Aetna and Caremark from its retail pharmacies and why the payvider model may have hit a wall as premiums outpace inflation and employers sue UnitedHealth. Then they dig into the midterm blue wave: Texas electing Democrat Gina Hinojosa as governor, the influencers mainstream media overlooks, Marcus's map of the fractured Republican coalition and the factions that formed the Democrats' big tent, and whether that tent can hold until 2028. From there, they ask what a Democratic health agenda could realistically look like: healthcare as 30% of the federal budget, the renewed case for Medicare for All, the debt spiral, AI's outsized share of GDP growth and the $2 trillion market sell-off, and why Medicaid work requirements and ACA subsidies may be the wins that matter most before closing on what the shift means for Anthropic's IPO. With insights into market trends, policy changes, and technological innovations shaping the future of health and money.


    Chapters


    0:00 Introduction: what a difference a week makes


    1:20 Rewriting Marcus's keynote overnight


    5:09 Why political shifts can't fix the debt cycle


    7:04 CVS plans to separate into two companies ↳

    https://www.sec.gov/Archives/edgar/data/0000064803/000119312526446150/d148827dex991.htm


    8:14 Family health premiums vs. inflation since 2000


    9:40 Employers sue UnitedHealth


    10:58 Has the payvider model hit a wall?


    12:42 The blue tsunami: election night reactions


    13:46 Texas flips: Governor-elect Gina Hinojosa


    14:22 What eroded Trump's base this year


    15:24 Young men swing 30% and the voices mainstream media misses


    16:34 The tech right alignment and the MAGA fracture


    20:32 The fractured factions of the Republican Party


    27:11 The factions that formed the Democrats' big tent


    28:13 Healthcare and science professionals run for office


    29:44 Red-state and suburban moderates: Talarico and Turek


    31:56 The progressive left: Sanders and El-Sayed


    33:38 The DSA's rise and AOC's renewed membership


    35:49 Zohran Mamdani's role in energizing the party


    36:33 Can the big tent hold until the 2028 primaries?


    37:35 What a Democratic health agenda could look like


    38:13 Healthcare is 30% of the federal budget


    39:40 The case for Medicare for All, and the pushback


    43:57 Medicare for All and the GENIUS Act as irreversible plays


    45:31 The debt spiral: 10-year yields vs. the CBO baseline


    46:26 AI's share of GDP growth


    47:14 The $2 trillion sell-off as a message to Democrats


    49:27 Regulate, slow or pause AI?


    52:34 Why healthcare stays a strong market under either party


    53:23 What can pass: Medicaid work requirements and ACA subsidies


    57:43 What the election means for Anthropic's IPO


    #Midterms2026 #HealthPolicy #CVSHealth #Aetna #PBM #UnitedHealth #MedicareForAll #Medicaid #ACA #FederalDebt #AI #Anthropic #Healthcare #HealthFurther


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    1 h et 1 min
  • 213 - Debt Hits 100% of GDP, HCA Bleeds on ACA Losses & Is Anthropic the Next Meta?
    Oct 30 2026
    In this episode, Marcus celebrates Nashville SC’s Supporters’ Shield and he and Vic dig into federal debt hitting 100% of GDP, accelerating inflation and a Fed holding steady before the midterms, new raises for ClarityCare and Midstream Health, the PBM transparency rule, Medicaid work requirements, RFK Jr. greenlighting unapproved peptides, Centene’s layoffs, big tech’s prior auth pledge, HCA’s ACA losses versus Tenet’s beat, UHS’s soft volumes, Bon Secours’ $5.7B bid for Surgery Partners, Risant’s Integris deal, Lilly’s retatrutide win and 39% revenue growth, the ChatGPT seizure medication lawsuit, DTCC’s tokenization launch, Anthropic’s IPO prospectus, Doximity’s dosing study, and how AI quietly shapes expert judgment with insights into market trends, policy changes, and technological innovations shaping the future of health and money.Chapters0:00 Introduction3:17 Federal debt hits 100% of GDP for the first time since 1946 ↳https://www.wsj.com/economy/federal-debt-hits-100-of-gdp-585d3cb06:05 PCE inflation accelerates in September ↳https://www.wsj.com/economy/central-banking/pce-inflation-accelerated-last-month-5f72a43f6:37 Fed holds rates as Cook and Hammack dissent in favor of a hike ↳https://www.wsj.com/economy/central-banking/federal-reserve-interest-rate-decision-df1206677:57 ClarityCare raises $16.5M to speed up prior authorizations ↳https://medcitynews.com/2026/10/claritycare-raises-16-5m-to-speed-up-prior-authorizations/8:58 Midstream Health secures $20M for its health system financial operations AI platform ↳https://www.modernhealthcare.com/health-tech/ai/mh-tracking-ai-healthcare-live-updates9:48 PBMs face new transparency mandates under Labor Department rule ↳https://www.modernhealthcare.com/politics-regulation/mh-labor-department-pbm-transparency-rule10:51 Court voids CMS's Medicaid medical frailty work requirement policy ↳https://www.modernhealthcare.com/politics-regulation/mh-court-cms-medicaid-medical-frailty12:06 RFK Jr. allows unapproved peptides on the market ↳https://www.wsj.com/health/healthcare/rfk-jr-allows-unapproved-peptides-on-the-market-9cf4a6d315:44 Centene progresses on profit recovery, cuts 6,000 jobs ↳https://www.healthcaredive.com/news/centene-progresses-profit-recovery-cuts-workforce-by-6k/872816/16:46 Five major companies pledge faster electronic prior authorizations ↳https://www.healthcaredive.com/news/five-major-companies-pledge-faster-electronic-prior-authorizations/833848/18:40 HCA's bottom line suffers as ACA coverage losses mount ↳https://www.healthcaredive.com/news/hcas-bottom-line-suffers-aca-coverage-losses-mount/873032/20:52 Tenet sails past Q3 earnings estimates, boosts 2026 guidance ↳https://www.fiercehealthcare.com/providers/tenet-healthcare-sails-past-q3-earnings-estimates-boosts-2026-guidance22:28 Softer surgery volumes dampen UHS's Q3 earnings ↳https://www.healthcaredive.com/news/softer-surgery-volumes-hospital-woes-dampened-uhs-q3-earnings/873190/23:58 Bon Secours affiliate makes $5.7B bid for Surgery Partners ↳https://www.healthcaredive.com/news/bon-secours-affiliate-5-7-billion-bid-surgery-partners/872887/25:49 Risant Health to acquire Integris Health ↳https://www.modernhealthcare.com/mergers-acquisitions/mh-risant-health-integris-kaiser-permanente29:19 Lilly's triple-G drug retatrutide tops Ozempic in head-to-head trial ↳https://medcitynews.com/2026/10/eli-lilly-retatrutide-type-2-diabetes-glp-1-gip-glucagon-metabolic-ozempic-lly/30:51 Eli Lilly's revenue climbs on demand for obesity drugs ↳https://www.wsj.com/health/pharma/eli-lilly-revenue-climbs-on-demand-for-mounjaro-zepbound-a6d810a531:53 Family blames ChatGPT after woman stops her seizure medication ↳https://gizmodo.com/a-woman-asked-chatgpt-how-to-get-off-her-seizure-meds-her-family-says-it-killed-her-200083259136:41 DTCC brings $30 trillion in securities closer to blockchain with major banks ↳https://www.coindesk.com/business/2026/10/28/wall-street-backbone-dtcc-brings-usd30-trillion-securities-closer-to-blockchain-with-major-banks38:00 The biggest takeaways from Anthropic's IPO prospectus ↳https://www.wsj.com/risk-compliance-journal/the-morning-risk-report-the-biggest-takeaways-from-anthropics-ipo-prospectus-f786ea5e49:01 Popular AI models get medication doses wrong, some dangerously ↳https://www.healthcaredive.com/news/popular-ai-models-get-medication-doses-wrong-some-dangerously-doximity/873207/51:14 Anthropic study finds expert judgment can be easily hacked by AI ↳https://gizmodo.com/expert-judgement-can-be-easily-hacked-by-ai-anthropic-study-finds-2000832143#HealthPolicy #FederalReserve #PBMTransparency #Medicaid #Peptides #PriorAuthorization #MedicareAdvantage #ACA #ProviderConsolidation #EliLilly #GLP1 #Pharma #Tokenization #HealthTech #AI #Anthropic #Healthcare #HealthFurther
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    1 h et 2 min
  • 212 - CON Laws, the COINS Act & Rogue AI Agents in Your Bank Account
    Oct 23 2026
    In this episode, Marcus is back from Oaxaca and he and Vic dig into Wall Street's nerves over Meta's AI capex and what rising rates and the Iran war mean for the AI buildout, jobless claims that don't match what we're seeing on the ground, BMS leading Pathos AI's $237M Series E and the biotech surge, OMass's $310M raise for a rare endocrine disorder, the Trump administration tying rural health dollars to Certificate of Need rollbacks, Treasury sweeping biotech into the COINS Act while sparing Big Pharma's China deals, friend of the show Rick Abramson on why the FDA should assess GenAI tools like physicians, family health plan costs climbing past $28K, Elevance's raised guidance, what new insurer entrants think they can do differently, Abbott's nutrition spinoff, the Quest Diagnostics breach, violence driving nurses from the profession, Moderna's leaked cancer vaccine data, GSK's hepatitis B approval, GLP-1s and breastfeeding, the OCC's GENIUS Act stablecoin rules, the AI-found PHP bug putting 70% of websites at risk, unvetted AI agents inside bank accounts, and why Anthropic can't afford to delay its IPO — with insights into market trends, policy changes, and technological innovations shaping the future of health and money.Chapters0:00 Introduction3:45 Meta's hunt for AI capital rattles Wall Street ↳https://www.wsj.com/finance/stocks/metas-hunt-for-ai-capital-strikes-a-raw-nerve-on-wall-street-e2de160113:58 US jobless claims return to a downward trend ↳https://www.wsj.com/economy/jobs/u-s-jobless-claims-return-to-downward-trend-9ba853fc16:26 BMS leads Pathos AI's $237M Series E alongside an Alzheimer's collaboration ↳https://www.fiercebiotech.com/biotech/pathos-ai-closes-237m-series-e-heels-bms-alzheimers-link19:19 OMass raises $310M for a rare endocrine disorder drug ↳https://medcitynews.com/2026/10/startup-omass-rare-disease-endocrine-hormone-melanocortin-2-mc2-cah/20:19 Trump dangles rural health funds to push states to change CON laws ↳https://www.modernhealthcare.com/politics-regulation/mh-trump-rural-health-certificate-need-laws/29:06 Treasury sweeps biotech into proposed COINS Act restrictions, spares Big Pharma's China licensing ↳https://www.fiercebiotech.com/biotech/treasury-sweeps-biotech-proposed-coins-act-restrictions-spares-big-pharma-china-licensing35:35 FDA's Rick Abramson: GenAI tools will need to be assessed like a physician ↳https://medcitynews.com/2026/10/fda-official-believes-genai-enabled-tools-will-need-to-be-assessed-like-a-physician/38:46 Family health plan costs rise as employers shift more to workers ↳https://www.wsj.com/health/healthcare/in-era-of-runaway-health-inflation-employers-scramble-to-keep-costs-in-check-fdae86df42:04 Elevance raises full-year guidance on lower medical costs ↳https://www.modernhealthcare.com/insurance/mh-elevance-earnings-third-quarter-2026-outlook43:27 What new insurer entrants think they can do differently ↳https://www.modernhealthcare.com/insurance/mh-health-systems-insurance-plans-included-nice50:56 Abbott to carve out its nutrition business ↳https://www.wsj.com/health/healthcare/abbott-to-carve-out-nutrition-business-into-independent-company-e9384a1551:57 Quest Diagnostics' test-results system breached in cyberattack ↳https://www.fiercebiotech.com/medtech/quest-diagnostics-test-results-system-breached-yet-another-medtech-cyberattack55:35 Nurses are in high demand, but they're quitting in droves ↳https://www.wsj.com/health/healthcare/nurses-are-in-high-demandbut-theyre-quitting-in-droves-d8ead94f1:01:23 Moderna shares fall after cancer vaccine data leaks on social media ↳https://www.wsj.com/health/pharma/moderna-cancer-vaccine-data-leaks-early-shares-plummet-f6bc4b4f1:04:27 GSK wins FDA approval for hepatitis B drug Hibsago ↳https://medcitynews.com/2026/10/gsk-chronic-hepatitis-b-fda-approval-bepirovirsen-hibsago-functional-cure-ionis-aso-ions/1:05:21 Weight-loss drugs may be OK while breastfeeding ↳https://www.wsj.com/health/wellness/a-no-no-during-pregnancy-weight-loss-drugs-may-be-ok-while-breast-feeding-d2e72baf1:07:09 The OCC finalizes GENIUS Act stablecoin rules ↳https://decrypt.co/381502/occ-finalizes-genius-act-stablecoin-rules-ahead-of-january-deadline1:10:57 AI finds a PHP bug that puts up to 70% of the world's websites at risk ↳https://www.wsj.com/tech/cybersecurity/ai-just-found-a-bug-that-puts-up-to-70-of-the-worlds-websites-at-risk-fd0902ea1:15:18 Unvetted AI agents are operating inside US bank accounts ↳https://www.axios.com/2026/10/22/ai-agents-banks-unauthorized-accounts-access1:18:09 Why Anthropic can't afford to delay its IPO ↳https://www.axios.com/2026/10/21/anthropic-ipo-ai-costs#AICapex #Meta #JobsReport #Economy #VentureCapital #HealthTechVC #Biotech #CertificateOfNeed #RuralHealth #COINSAct #FDA #GenAI #HealthcareCosts #HealthInsurance #Cybersecurity #Nursing #Moderna #GLP1 #Stablecoins #GENIUSAct #AIAgents #Anthropic
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    1 h et 30 min
  • 211 - Hospitals Can't Hide Behind CMS Anymore: The FTC, Medical Bill Revolts & the Battle of the AIs
    Oct 9 2026
    In this episode, Vic is joined by Emily Evans, sitting in for Marcus, to talk through her book on the two competing philosophies that have shaped American healthcare, a September jobs report shaped by shifting immigration dynamics, Fed minutes and the return of bond market volatility, Healthleap's AI for flagging undiagnosed hospital patients, Matchpoint Therapeutics' $150M raise and the promise of immune-based therapies, the FTC's warning letters to 24 health systems over price transparency, HHS's plan to allow some unapproved peptides as Chinese manufacturers flood the U.S. with bootleg versions, Texas AG Ken Paxton's probe of UnitedHealth, the "battle of the AIs" between payers and providers, GE HealthCare's $945M bet on radiopharmaceuticals, the optogenetics Nobel Prize, influencers urging patients not to pay their medical bills, tokenized stocks and stablecoin remittances, Biohub's $1.8B push for AI-ready biological data, OpenAI's 722 math proofs, and the enterprise AI price war between OpenAI and Anthropic — with insights into market trends, policy changes, and technological innovations shaping the future of health and money.Chapters0:00 Introduction0:47 Emily's book: universal care vs. incrementalism in American healthcare3:46 September jobs report: hiring trudges along ↳https://www.wsj.com/economy/jobs/september-jobs-report-unemployment-6b6d66436:48 Fed minutes, the deficit and the return of bond market volatility ↳https://www.wsj.com/economy/central-banking/fed-minutes-signal-further-rate-increase-this-year-but-no-urgency-for-october-hike-54ec759f10:13 Healthleap raises $38M for AI that flags hospital patients who need a closer look ↳https://techcrunch.com/2026/10/07/healthleap-raises-38m-for-its-ai-that-flags-hospital-patients-who-may-need-a-closer-look/15:02 Matchpoint Therapeutics raises $150M Series B ↳https://www.fiercebiotech.com/biotech/matchpoint-nets-150m-series-b-take-covalent-med-clinic19:31 Parakeet Health raises $10M for conversational AI ↳https://medcitynews.com/2026/10/parakeet-health-secures-10m-for-conversational-agentic-platform/23:51 The FTC warns 24 health systems over price transparency ↳https://www.beckershospitalreview.com/legal-regulatory-issues/the-ftcs-healthcare-crackdown-9-things-to-know/31:14 HHS plans a stopgap to allow some unapproved peptides ↳https://www.beckershospitalreview.com/glp-1s/hhs-plans-stopgap-to-allow-sales-of-some-unapproved-peptides-washington-post/36:01 Texas AG Ken Paxton investigates UnitedHealth over care denials ↳https://www.healthcaredive.com/news/texas-ken-paxton-unitedhealth-investigation-care-denials/832221/38:22 Fitch: humans will stay in the loop on AI prior auth ↳https://www.beckershospitalreview.com/finance/revenue-cycle-management/fitch-human-review-in-ai-prior-authorization-denials-likely-here-to-stay/40:27 GE HealthCare buys SOFIE for nearly $1B ↳https://www.wsj.com/health/healthcare/ge-healthcare-to-buy-sofie-for-nearly-1-billion-to-grow-medical-imaging-business-cfca031842:56 The outpatient shift accelerates as hospital margins rebound ↳https://www.healthcaredive.com/news/outpatient-shift-accelerates-hospital-margins-rebound-strata/832490/44:51 Nobel Prize in Physiology or Medicine goes to optogenetics ↳https://www.wsj.com/science/trio-awarded-nobel-prize-in-physiology-or-medicine-for-neuroscience-discoveries-55005d9547:06 Chinese makers of fentanyl ingredients now sell bootleg peptides ↳https://www.wsj.com/health/pharma/chinese-makers-of-fentanyl-ingredients-now-sell-bootleg-peptides-to-americans-c383160b50:14 The influencers on a mission to stop people from paying medical bills ↳https://www.wsj.com/health/healthcare/these-influencers-are-on-a-mission-to-stop-people-from-paying-medical-bills-4843da3d1:00:14 Securitize launches tokenized stock trading ↳https://www.wsj.com/livecoverage/stock-market-today-dow-sp-500-nasdaq-10-08-2026/card/securitize-launches-tokenized-stock-trading-for-u-s-investors-dUqrm7mXGjwUrAdo4x6M1:01:46 Samsung adds USDC cross-border payments to Galaxy Wallet ↳https://cryptorank.io/news/feed/4d678-samsung-wallet-usdc-solana1:03:21 Biohub, DOE and NIH back $1.8B in biological data for AI ↳https://www.wsj.com/tech/ai/zuckerbergs-biohub-partners-with-doe-nih-to-invest-1-8-billion-in-biological-data-for-ai-models-f8d5f7991:08:34 OpenAI's math breakthrough points beyond math ↳https://www.axios.com/2026/10/08/openai-math-proofs-ai-model1:12:20 The AI price war heats up as OpenAI gains on Anthropic ↳https://www.wsj.com/tech/ai/the-ai-price-war-is-heating-upand-openai-is-gaining-ground-on-anthropic-48b8525b#HealthcarePolicy #PriceTransparency #FTC #Peptides #FDA #HHS #UnitedHealth #PriorAuth #Radiopharmaceuticals #NobelPrize #Optogenetics #MedicalDebt #JobsReport #FederalReserve #VentureCapital #HealthTechVC #Tokenization #Stablecoins #AI #OpenAI #Anthropic
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    1 h et 25 min
  • 210 - Private Markets for Everyone, Grail's FDA Win & the Rise of Consumer AI Agents
    Oct 2 2026
    In this episode, Marcus and Vic bring the headlines back: why 10-year Treasury yields at their highest level since 2002 signal a fiscal problem healthcare can't ignore, how Trump's agenda has pushed up rates and inflation, Neko Health's $700M bet on whole-body scanning and Precision Neuroscience's $250M Series D, the GLOBE rule's shrinking Medicare savings, the SEC opening private markets to ordinary investors, HHS's push to redesign clinical trials, Cigna's AI-driven savings, UPMC's acquisition of Trinity Health, Epic's pause to focus on cybersecurity, the FDA panel backing Grail's Galleri test, the FTC's probe of OpenAI and Anthropic, and the arrival of consumer AI agents like OpenAI's Dots with insights into market trends, policy changes, and technological innovations shaping the future of health and money.Chapters0:00 Introduction2:20 August PCE inflation reading ↳https://www.wsj.com/livecoverage/stock-market-today-dow-sp-500-nasdaq-09-30-2026/card/what-to-know-about-today-s-pce-index-YnU6yGlmCpHowo8u4TSP 3:16 US bond yields hit their highest level since 2002 ↳https://www.nytimes.com/2026/10/01/business/bond-yields-10-year-treasury.html 7:28 How Trump's economic moves drove rates and inflation higher ↳https://www.wsj.com/economy/trump-economy-inflation-jobs-724e4da8 10:15 Neko Health's $700M bet on whole-body scanning ↳https://techcrunch.com/podcast/the-investor-behind-neko-healths-700m-bet-on-scanning-your-whole-body/ 12:54 Precision Neuroscience's $250M Series D for brain-computer interfaces ↳https://www.fiercebiotech.com/medtech/precision-neuroscience-taps-250m-series-d-funding-brain-computer-interface 16:29 CMS finalizes the GLOBE rule as projected savings shrink ↳https://endpoints.news/cms-finalizes-globe-medicare-demo-but-savings-trail-projections/ 20:56 The SEC expands private-market access for ordinary investors ↳https://www.wsj.com/pro/private-equity/sec-moves-to-give-ordinary-investors-more-access-to-private-equity-d4108681?st=ZNfSmp&reflink=desktopwebshare_permalink 23:32 Public market headwinds: Oura's paused IPO and Anthropic's losses ↳https://www.wsj.com/tech/oura-postpones-ipo-over-market-uncertainty-49d49791https://decrypt.co/379605/anthropic-lost-42-billion-last-year-wants-ipo-2-trillion 30:40 HHS launches a project to speed up clinical trials ↳https://www.axios.com/2026/09/30/hhs-clinical-trials-redesign 33:52 Cigna expects $3B in savings from AI and automation ↳https://www.modernhealthcare.com/insurance/mh-cigna-investor-day-ai-pharmacy 34:30 UPMC acquires CommonSpirit's Trinity Health ↳https://www.modernhealthcare.com/mergers-acquisitions/mh-upmc-trinity-health-system-commonspirit 35:30 Epic pauses product development to focus on cybersecurity ↳https://www.modernhealthcare.com/health-tech/mh-epic-systems-pause-product-development-ai 37:15 The FDA panel on Grail's Galleri test and the Medicare question ↳https://www.wsj.com/health/healthcare/a-cancer-test-has-investors-betting-big-but-will-insurers-pay-75d3bc60 42:00 The FTC probes OpenAI and Anthropic over AI safety ↳https://www.axios.com/2026/09/30/ftc-openai-anthropic-ai-safety-investigation 53:01 OpenAI launches Dots and the rise of consumer AI agents ↳https://techcrunch.com/2026/09/29/openai-launches-dots-its-bubbly-agentic-avatar/ #NationalDebt #BondYields #FiscalDominance #Inflation #Economy #HealthcareCuts #CMS #FDA #Grail #ClinicalTrials #VentureCapital #HealthTechVC #PrivateMarkets #SEC #HealthSystemMandA #Cybersecurity #AI #AISafety #AIAgents #HealthcarePolicy
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    1 h et 2 min
  • 209 - No Stories, Just Conviction: The Debt, Healthcare Cuts, and What Comes Next
    Sep 25 2026

    In this episode, Marcus and Vic set the headlines aside for UN General Assembly week and test their worldviews across every theme of the show: why the national debt and fiscal dominance matter more than the Fed, what a multipolar world means for healthcare funding, why neither party can stop the cuts that started with HR1, how AI is reshaping venture capital, the FDA as the administration's bright spot, stablecoin rails as a challenger to claims clearinghouses, the frontier labs' communication and business-model problems, and a friendly debate over whether AI will cost jobs or spark a new wave of entrepreneurship — with insights into market trends, policy changes, and technological innovations shaping the future of health and money.


    Key Topics


    Why covering the Fed feels less meaningful in an era of fiscal dominance

    Debt-to-GDP nearing World War II levels and the cost of debt service

    UN General Assembly week, diversification, and the shift to a multipolar world

    Why healthcare rarely talks about the national debt — and why HR1 is just the beginning

    The Fourth Turning, Ray Dalio's debt cycles, and a coming day of reckoning

    The midterms, legislative vs. executive power, and why neither party can fix inflation

    What the Paramount deal says about consolidation and corporate leverage

    Health systems cutting vendors and what that means for startups

    AI lowering the capital needed to build a company — and LP-driven mega-funds

    Impact investing, value-based care, and the timeline problem

    FDA and CMS policy: the inpatient-only list, value-based care, and telehealth limbo

    Stablecoin rails and programmatic claims as a shot at healthcare's $1 trillion settlement cost

    Frontier AI labs, the gain-of-function analogy, and cybersecurity over extinction talk

    AI and jobs: middle management, entrepreneurship, and community resilience


    Chapters


    0:00 Introduction and episode overview

    2:04 The shifting focus on the economy and debt levels

    3:59 Geopolitical changes and the move towards a multipolar world

    7:51 Healthcare system challenges and policy implications

    23:03 Venture capital trends and health tech investments

    35:00 Policy updates and regulatory environment in healthcare

    38:00 The role of AI and Web3 in industry transformation

    53:01 The societal impact of AI and future job markets

    1:02:00 Concluding thoughts and future outlooks


    #NationalDebt #FiscalDominance #Economy #Inflation #Midterms #VentureCapital #HealthTech #Biotech #HealthSystems #CMS #FDA #ValueBasedCare #Telehealth #RevenueCycle #Web3 #Stablecoins #Blockchain #AI #AISafety #FutureOfWork #Entrepreneurship #HealthcarePolicy


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    1 h et 19 min
  • 208 - Hospital Margins Crater, Half of Hospitals Still Hide Prices, and OpenAI's $1.2T Question
    Sep 18 2026

    In this episode, we explore Vic's takeaways from Nashville Healthcare Sessions and the OpenAI-HCA partnership, a Fed rate hike to 3.75%-4% under new Chairman Kevin Warsh, a wave of nine-figure health rounds, the hollowing out of hospital margins and price transparency compliance, a potential CRISPR successor called Viper, and OpenAI's $1.2 trillion valuation push amid new AI safety disclosures — with insights into market trends, policy changes, and technological innovations shaping the future of health and money.

    Key Topics

    Nashville Healthcare Sessions recap and the OpenAI-HCA partnership
    Jobless claims fall to 196K, but the labor-force participation rate tells a different story US housing starts slip as affordable inventory stays stuck
    The Fed raises rates 25bps to 3.75%-4% under new Chairman Kevin Warsh
    VC Rundown: Thatch hits a $1B valuation, Sling raises $123M, and Evvy raises $40M
    CMS expands the ACCESS model's chronic conditions for 2027
    More than half of hospitals still aren't compliant with price transparency rules
    Hospital operating margins fall to 1.4% amid outpatient slowdowns
    The widening mental-health and turnover gap among physicians and Gen Z clinicians
    Viper: a newly discovered gene-editing system that may outperform CRISPR
    GSK commits up to $750M for a new multiple myeloma therapy
    Tokenized securities get a 5-year SEC exemption after the Clarity Act fails in the Senate
    Circle launches its ARC stablecoin blockchain with BlackRock and Visa
    OpenAI's new AI safety incidents, its $1.2 trillion valuation push, and the case for AI product liability
    AI as a co-scientist: accelerating drug discovery at Stanford

    Chapters
    0:00 Introduction — Vic recaps Nashville Healthcare Sessions and the OpenAI-HCA partnership
    2:13 Marcus on a loaded week in Nashville — family, civic work, and a strong portfolio
    4:21 Jobless claims fall to 196K, but the participation rate tells the real story
    6:49 US housing starts slip as affordable inventory stays stuck
    8:30 The Fed raises rates 25bps to 3.75%-4% under Chairman Kevin Warsh
    12:50 VC Rundown: Thatch secures $108M Series C, hits $1B valuation
    14:31 Sling raises $123M Series C for an oral GLP-1 rival
    15:03 Evvy raises $40M for vaginal microbiome research
    15:55 CMS adds more chronic conditions to the ACCESS model for 2027
    17:29 More than half of hospitals still aren't compliant with price transparency rules
    21:17 Hospital operating margins fall to 1.4% amid outpatient slowdowns
    22:10 The mental-health gap widens between employed and independent physicians
    23:19 70% of Gen Z healthcare workers say they'll quit within a year
    25:28 Viper: a gene-editing system that may predate — and outperform — CRISPR
    27:08 Sickle cell's cure and the case that healthcare's old model is approaching deprecation
    31:14 GSK commits up to $750M for Chimeric Biosciences' multiple myeloma drug
    32:21 SEC rolls out a 5-year innovation exemption for tokenized securities
    34:30 Why the Senate's Clarity Act failed
    36:16 Circle launches ARC, a stablecoin blockchain, with BlackRock and Visa
    38:54 OpenAI discloses six new AI safety incidents tied to its Astra models
    39:50 Astra's misalignment problem — and why Jensen Huang calling it AGI is unsettling
    41:54 "Get control of your own models" — the case for AI product liability
    43:08 Talking to family about AI risk, and the UL/electricity analogy for AI safety
    53:21 Staying patient and clear with people who fear AI amid election-season hype
    56:00 Jensen Huang as master communicator — and why the labs need better spokespeople
    58:06 OpenAI eyes a $1.2 trillion valuation ahead of a potential IPO
    1:01:11 "Who's going to buy this?" — OpenAI's valuation vs. its business model and moat
    1:02:16 Open-source models close the gap and erode the frontier labs' moat
    1:06:21 AI as a co-scientist: Stanford researchers accelerate drug discovery
    1:08:19 Turning the corner — from chronicling healthcare's decline to its ascent
    1:08:43 What comes next: allocating a 10,000x increase in care capacity

    #FederalReserve #Inflation #JobsReport #Housing #VentureCapital #Biotech #CMS #PriceTransparency #HospitalMargins #PhysicianBurnout #GeneEditing #CRISPR #Oncology #Web3 #StablecoinPayments #SEC #AI #OpenAI #AISafety #DrugDiscovery #HealthcarePolicy

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    1 h et 12 min