Speaker-Organized Summary: Go Unpro Podcast, Week 5

Dr. Brent Laartz

Key Points and Decisions:

Experienced a setback over the holidays with increased alcohol and food intake due to family events and his father's passing

Committed to a "Dry January" to limit alcohol intake and get back on track with his health goals

Discussed the importance of mitochondria and how they impact energy, immune function, and response to diet

Emphasized the need for a gradual, sustainable approach to lifestyle changes rather than drastic "cold turkey" changes

Next Steps:

Continuing to focus on a whole-food, plant-based diet with limited processed foods and alcohol

Incorporating more fermented foods to support gut health and microbiome

Maintaining a consistent exercise routine with a focus on strength training and cardiovascular fitness

Practicing creativity through daily poem writing and sharing on "Friday Frhyme Day"

Increasing social connections and reducing stress through meditation and sleep optimization

Summary

In this episode, Dr. Brent Laartz discussed his journey towards an unprocessed life, including the challenges he faced over the holiday season and his renewed commitment to his health goals. He emphasized the importance of mitochondrial health and how it impacts energy, immune function, and response to diet.

Dr. Laartz emphasized the need for a gradual, sustainable approach to lifestyle changes rather than drastic "cold turkey" changes. He outlined his next steps, which include continuing to focus on a whole-food, plant-based diet, incorporating more fermented foods, maintaining a consistent exercise routine, practicing creativity through daily poem writing, and increasing social connections and reducing stress through meditation and sleep optimization.

Throughout the episode, Dr. Laartz shared his personal vision for longevity and health, and how he is working towards achieving his "Blue Zone" lifestyle goals.

Speaker-Organized Summary: Key Points, Decisions, and Next Steps

Announcer Lucas

Welcome to Sunday Science, where recent scientific articles and their translation into modern lives are discussed.

The host for today's episode is Dr. Brent W. Lartz, M.D.

Dr. Brent Laartz

Summary of Key Points and Decisions

The discussion focuses on a gene and gene product called Clotho, which was discovered in 1997 and is named after the Greek god of fate and destiny.

Knockout mice with Clotho upregulation showed a 15-30% longer lifespan and improved cardiovascular, renal, and brain health, as well as lower rates of cognitive decline.

However, a recent study published in the Journals of Gerontology in 2025 found a U-shaped relationship between Clotho levels and all-cause mortality.

The study showed that both high and low levels of Clotho were associated with increased mortality, and this was linked to increased liver fibrosis.

Next Steps

Further research is needed to fully understand the relationship between Clotho levels and health outcomes.

Multiple studies on Clotho have been published in the past year, and more are expected in the next one to two years.

The speaker encourages the audience to follow the podcast on various platforms to stay updated on the latest developments in longevity and science.

Summary of Key Points, Decisions, and Next Steps by Speaker

Dr. Brent Laartz

Key Points and Decisions:

Focusing on longevity and healthspan, not just cosmetic appearance

Importance of polyphenols, calorie restriction, and certain medications (acarbose, canaglifosin) for longevity

Emphasis on strength, grip strength, and quick movements to maintain activity into older age

Strategies for navigating the holidays, including bringing own food, doing active activities with family, and tracking progress

Next Steps:

Continuing low-carb, no-sugar diet with focus on whole foods, vegetables, and limited pasta/bread

Increasing cardiovascular exercise to 3 times per week and resistance training 2-3 times per week

Improving sleep habits, including using Oura ring, avoiding screens before bed, and exploring 40Hz light/sound therapy

Engaging in more mindfulness, creativity, and connection activities like writing, music, and spending time with loved ones

Further reducing plastic use by switching to cotton clothing, glass/stainless steel cookware and utensils, and natural oral hygiene products