Key Episode Takeaways

Oral Wegovy is real, but it’s not “just a pill version of the shot.” Absorption rules, dosing schedules, and patient selection matter a lot more than most headlines suggest.

Switching from injections to oral GLP-1s requires a plan. The transition isn’t one-size-fits-all, and dose timing, GI tolerance, and expectations need to be managed carefully.

Weight regain after stopping GLP-1s is common, but not universal. SURMOUNT-4 data shows large variability, reinforcing that biology, not willpower, drives outcomes.

Maintenance matters as much as weight loss. Some patients need continued therapy at lower doses, while others may maintain with lifestyle plus strategic medication use.

Stopping abruptly is usually the worst approach. Gradual transitions and realistic long-term strategies reduce rebound weight gain.

GLP-1s are chronic disease tools, not short-term fixes. Treating obesity like hypertension or diabetes leads to better outcomes and fewer surprises.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways:

Dietary guidelines have evolved since the 1980s.

The food pyramid was introduced in 1992 and has influenced public perception.

New dietary guidelines emphasize healthy fats but retain some old recommendations.

There are contradictions in the new guidelines regarding saturated fat and protein intake.

The definition of processed foods remains vague and controversial.

The guidelines are intended for healthcare professionals, not consumers.

Public policy needs to align with dietary guidelines for effective implementation.

The emphasis on real food is not a new concept in dietary guidelines.

There is skepticism about whether the new guidelines will lead to meaningful changes in public health.

The conversation around dietary guidelines is often politically charged.

Follow Kevin: Tap Here

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Takeaways:

Cortisol is essential for various bodily functions, especially during stress.

Adrenal glands have a circadian rhythm that affects cortisol production.

Cushing's syndrome can result from excess cortisol and has specific symptoms.

Diagnosis of adrenal disorders requires careful testing and consideration of symptoms.

Mild autonomous cortisol secretion can complicate diabetes management.

The Catalyst trial explored the effects of cortisol antagonism on diabetes.

Future research may focus on selective glucocorticoid receptor modulators.

Woolly mammoth studies provide insights into historical testosterone levels.

Understanding adrenal health is crucial for effective patient care.

Endocrinologists must navigate the complexities of hormone testing and treatment.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.