Genflow Biosciences (LON:GENF / OTCQB:GENFF) has reported encouraging interim results from its SLAB-VET-001 study, giving investors an early look at how its centenarian-derived SIRT6c gene therapy performs in naturally aged dogs. CEO Dr Eric Leire explains why the findings matter, why plasmid DNA has emerged as the preferred veterinary delivery route, how the data are accelerating discussions with animal health companies and why progress in dogs could have wider implications for Genflow’s human sarcopenia programme.

Key Moments

00:09 – SLAB-VET delivers an important milestone
Dr Leire explains why testing SIRT6c in naturally aged dogs marks a significant step.

00:44 – A centenarian-derived gene moves into real-world ageing
Early signs from older animals provide a new test of Genflow’s longevity approach.

01:05 – Why pDNA is leading the veterinary programme
Lower manufacturing costs, scalability and a potentially simpler safety profile underpin the choice.

01:39 – Repeat dosing could strengthen the commercial case
Dr Leire highlights practical advantages over viral-vector delivery.

02:11 – Toronto data draw industry attention
Scientists, delegates and animal health companies focus on changes in biological age and muscle performance.

02:37 – Naturally aged dogs add translational relevance
The study differs from laboratory models engineered to accelerate ageing.

03:11 – Results accelerate licensing discussions
Genflow says the presentation has strengthened engagement with potential commercial partners.

03:33 – Partnering rather than building an animal-health business
The company is targeting licensing, milestone and royalty structures or a potential outright asset sale.

04:19 – Three catalysts investors should watch
Veterinary partnering, patent progress and advancement of the human programmes take centre stage.

04:25 – A veterinary deal could bring non-dilutive value
Management sees partnering as a potential source of capital and external validation for the platform.

04:44 – Europe and Japan patent progress
Genflow expects further intellectual-property milestones around its SIRT6 technology.

05:04 – Sarcopenia moves higher up the agenda
Positive dog data increase the relevance of Genflow’s work targeting age-related muscle decline in humans.

05:30 – Why dogs may matter more than mice
Shared environments and lifestyles could make naturally aged dogs a more relevant translational model.

05:50 – Eye and liver programmes add further optionality
Genflow continues to advance additional therapeutic opportunities beyond sarcopenia.

Oriole Resources CEO Martin Rosser explains why the 32.2Mt maiden resource at Wapouzé could support a multi-decade operation — and potentially generate income to help fund ORR’s gold strategy while limiting dilution.

Also covered: partner discussions, licensing, Mbe, Bibemi, Eastern CLP and Senala.

#ORR #Gold #Mining #Cameroon

Key Moments

00:13 – Wapouzé delivers a 32.2Mt maiden resource
Martin puts the scale and quality of the new resource into context.

00:50 – High-grade material with multi-decade potential
Why the calcium oxide grade, low magnesium content and proposed 400,000tpa operation matter.

01:30 – A route into Cameroon’s cement market
The potential to displace imported clinker and supply domestic cement production.

02:06 – More than a cement opportunity
Higher-grade material could also serve gold processing and chemical-grade markets.

02:39 – Location strengthens the commercial case
Wapouzé’s position offers potential access to customers in both Cameroon and neighbouring Chad.

03:22 – Moving from resource towards reserves
The technical, economic and mining work now required to advance the project.

03:50 – Exploitation licence work gathers pace
The PEA and environmental and social impact assessment form key parts of the application.

04:38 – Industry partner discussions move forward
Oriole is targeting established domestic players and international groups seeking exposure to the Cameroon and Chad markets.

05:44 – The resource strengthens Oriole’s negotiating position
The maiden MRE provides substantially more technical information to advance partner discussions.

06:27 – A potentially faster route to production
Martin explains why quarry development could require less capital and move more quickly than a conventional metals mine.

07:17 – Wapouzé could help fund the gold strategy
Oriole sees potential for royalty-based or other income that could support exploration while reducing dilution.

08:02 – Oriole’s portfolio takes shape
Martin reviews the 1.66Moz Mbe resource, 460,000oz at Bibemi, Wapouzé and Senala.

08:34 – From exploration towards development
The company is increasingly focused on defining routes to development and eventual gold production.

09:06 – The next portfolio catalysts
Bibemi licensing, Mbe economics, Eastern CLP exploration and results from Managem’s US$2m Senala programme are all in focus.

Hercules Plc (LON:HERC) has secured around £5m of new Civil Projects work in the final quarter of FY2026, with most of the contracts in the Thames Water region. CEO Brusk Korkmaz explains how growing self-delivery capability is changing the scale of work Hercules can pursue, why the £104bn-plus AMP8 investment programme could provide a multi-year growth runway, and how the business is positioning across six major UK water regions. He also sets out an ambition for Civil Projects delivery to potentially reach £50m-plus annually within five years as the division becomes an increasingly important contributor to group growth and profit.

Key Moments

• 00:23 – £5m of new contracts — Q4 wins strengthen the Civil Projects platform

• 01:19 – The £104bn AMP8 opportunity — Why UK water investment could drive years of growth

• 02:45 – Self-delivery changes the model — More control over safety, quality, cost and programme

• 03:59 – Relationships turn into opportunities — 18 years in water gives Hercules an early view of future work

• 05:11 – FY2027 growth priorities — Water remains central, with wider infrastructure opportunities emerging

• 07:08 – How much can Hercules capture — The CEO outlines the addressable opportunity across AMP8

• 07:28 – Six water regions already in play — Thames, Southern, Anglian, Severn Trent, Wessex and Yorkshire

• 08:06 – £50m-plus annual ambition — Brusk Korkmaz outlines how large Civil Projects could become within five years

#Hercules #HERC #UKStocks #Investing #Infrastructure #WaterSector #AMP8 #CivilEngineering #Construction #ThamesWater #AIM #UKInfrastructure

https://www.directorstalkinterviews.com/hercules-plc-5m-q4-wins-put-50m-civil-projects-ambition-in-focus-video/4121265473