Back in 2011, Sean Duffy had a vision to change healthcare. So, he dropped out of Harvard Business School and Harvard Medical School to found this company, Omada Health, that brought healthcare to people instead of the other way around.

Now valued at over $1 billion, Omada remains an innovative example of how to manage and treat chronic disease. But Sean’s not done yet. In this conversation, we talk about how we’re living in a time where we have the most innovative medicines ever created for metabolic disease. And, the most innovative technology landscape of all time. But the services landscape is absolutely failing, and so we have to look at how to redesign services and the business models that support those services so that we can realize the potential of those technology and treatment innovations.

Sean has always been a visionary, but the way he sees the field of healthcare rivals the best quarterbacks in history. Sean is the Co-founder and CEO of Omada Health, a between-visit care provider that addresses cardiometabolic conditions like diabetes, hypertension, prediabetes, and obesity, as well as musculoskeletal issues. As a former MD/MBA candidate at Harvard, he also holds a BS in neuroscience from Columbia University. He has written extensively about digital health and the future of healthcare in The New England Journal of Medicine, The Wall Street Journal, Forbes, and TechCrunch, among other publications. Prior to Omada, Sean worked at both Google and IDEO.

You can’t boil the ocean, and wow, does the state of primary care sometimes feel like an ocean. And if a behemoth like CVS Health can’t do it, it’s no surprise that the rest of us in healthcare feel at a complete loss for how to right this ship.

But our guest today, Amy Compton-Phillips, Executive VP and Chief Medical Officer of CVS Health, takes a different approach. If ⅓ of Americans don’t have a primary care provider and even if they wanted one, there aren’t enough to go around, AND there is no pipeline to train and certify new ones, then how do we take the resources we do have and stretch them in different ways? That is the work we talk about today – how CVS Health is using their 900 clinics and 9,000 stores to step into that void and help more people access basic primary care, or, as Amy puts it, “giving people the tools they need to live their best life.”

Amy has more than 30 years of clinical and operational experience, coming to CVS Health from her role as president and chief physician executive at Press Ganey, where she guided provider organizations and health plans through system-wide clinical transformation. Prior to Press Ganey, Amy served as president of clinical care at Providence, a national healthcare system, overseeing clinical operations across 51 hospitals and more than 1,000 clinics. A Board Certified internist herself, Amy serves as a medical analyst for CNN, where she communicated critical public health guidance during the COVID-19 pandemic.

Welcome to a new season of Creating a New Healthcare!

This season, we’re diving into primary care. That’s right, primary care. Because right now, we are sucking at primary care, and the problem has reached critical mass. AND, we are sitting on the precipice of a revolution in primary care – the ability to provide contextual care, the ability to assess precursors to disease, and the ability to treat those conditions far more effectively – they are all on our doorstep.

So, in this first episode, I sit down with my Producer, Jess Greenwood, to share my rationale on focusing this season on the revolution in primary care and what you, the audience, should be listening for with this season’s guests.

We’re quick to blame genetics for our health and wellness issues, but the reality is that genetics only makes up 18% of our health destiny. That means the rest is up to us.

Our guest today, Dr. Grant Zarzour, has seen that first hand in his own family. When his son was diagnosed with moderate autism, he and his wife refused to accept the predictions for his future. They dove head first into the data and in so doing, revolutionized not just their son’s life, but their own. Now a relentless proponent of diet, sleep, and exercise for physical and mental health, Dr. Zarzour feels like we all have a hand in our own destiny. We just have to commit.

Dr. Zarzour is a practicing hip and knee surgeon in Mobile, AL. He is the president of the largest orthopaedic practice in Alabama. While treating thousands of patients a year, Grant has developed a passion for preventive medicine. In 2024, he founded Sperity Health, which offers personalized longevity coaching to help its members improve their diet, exercise, and sleep with expert MD guidance. Sperity Health’s mission is to lower its member’s risk of cancer, cardiovascular disease, and dementia by up to 50% based on data and science.

As a society, and as an industrial complex, we’ve made health complicated…and expensive. But, epidemiology suggests that what we need to do to achieve and maintain personal health is really quite simple.

Dr. Tom Frieden returns to the show to talk about the second half of his book, The Formula for Your Health. Through extensive research and review of hundreds of epidemiological studies, he distills the findings down to six basic things we need to be doing in order to be healthy. Dr. Frieden acknowledges that there is nuance, but he also affirms that history is clear. There are other societies in the world that were and are far healthier than the US population, and NOT because they had wearables, packaged food, home massagers, or Pelotons.

Dr. Frieden is author of the book, The Formula for Better Health: How to Save Millions of Lives—Including Your Own. He is also the founder and CEO of Resolve to Save Lives, a global health organization that accelerates action against the world’s deadliest health threats. Resolve to Save Lives has worked with governments and other partners in more than 60 countries to save millions of lives. Dr. Frieden previously served as director of the U.S. Centers for Disease Control and Prevention (CDC) and New York City Health Commissioner, where he led efforts that increased life expectancy by 3 years and helped end major health crises including the largest US outbreak of multidrug-resistant tuberculosis, the 2014 West Africa Ebola epidemic, and responses to H1N1, Zika, and other threats.

With the recent explosion of GLP-1 drugs, the war on obesity seems to have taken a new and potent turn, but many are concerned about the recidivism, the side effects, and our reenergized obsession with being thin.

Our guest today, Dr. Laure DeMattia, is a board certified family medicine physician and obesity specialist. For her, obesity is personal, as she has struggled her entire life with this chronic condition. In this episode, Dr. DeMattia breaks down for us how GLP-1 drugs work to hyperdrive weight loss, why that loss is rarely sustainable without long term use of the drugs, and her own philosophy outside of medication that helps her patients feel seen, heard, and safe. It’s both an educational conversation and a behind-the-curtains look at the obesity epidemic from someone on the front lines.

Dr. Laure DeMattia helps women stop blaming themselves for their physiology and find lasting health for over 20 years. Her dual perspective as both a doctor and a patient makes her uniquely compassionate, challenging the myth that willpower is the solution. Author of the book, The 4 Food Cues, Dr. DeMattia hosts her own YouTube channel, Navigating Obesity with Dr. D, where she offers a compassionate, realistic viewpoint about weight and weight loss.

Do you have an Apple watch? Fitbit? Oura ring? Woop? Wearables have taken over in the past decade with claims that by constantly monitoring our heart rate, sleep, respiration, and activity, they can provide health data that can change your life. But is that really possible? Or even plausible?

Marco Benitez, former professional athlete, and the Founder and CEO of ROOK joins us on the Living Well series today to talk all things wearables. He sees tremendous potential with how the data these tools compile can be utilized across all aspects of our lives, including in our cars (!), to change our behavior. But he acknowledges there’s a catch. Many of these companies use the data collected not for YOUR benefit, but for theirs, and real change, well, there’s no magic bullet. It’s hard, takes time, and is all on you.

Raised in Mexico with an insatiable curiosity and entrepreneurial spirit, Marco Benitez built his career at the intersection of health, technology, and sports science. Starting as a Tae Kwon Do champion, Marco’s discipline and resilience guided him into biomedical engineering, then into high-stakes roles in pharmaceutical giants like Roche and Novartis. Here, he witnessed the transformative power of data in healthcare—and saw a profound opportunity to make health metrics more accessible and actionable. Determined to improve health management and bridge the gap between raw data and real impact, Marco co-founded ROOK.