Psilocybin for Cluster Headaches: The Yale "Pulse Protocol" Breakdown

Cluster headaches are often described as one of the most painful conditions known to medicine—frequently rated as more severe than childbirth or kidney stones. For those living with these "suicide headaches," traditional treatments often fall short.

In this video, Coeli Dwivedi breaks down a breakthrough 2024 study from the Yale School of Medicine. The research reveals a specific "pulse" protocol that resulted in a staggering 47% reduction in headache frequency.

🧠 KEY STUDY INSIGHTS:✨ The Pulse Protocol: Understanding the exact 3-dose regimen (Day 0, 5, and 10) and why timing matters more than intensity.✨ The Results: Breaking down the 0.97 effect size and the massive reduction in "abortive" medication use.✨ Neurological Context: How psilocybin interacts with neural systems involved in pain regulation and rhythmic patterning.

🕒 CHAPTERS:0:00 Introduction to Cluster Headaches1:01 Yale School of Medicine Study Review2:35 The Pulse Protocol: Timing & Dosage3:13 Breaking Down the Results3:59 Key Findings & Data4:46 Limitations of the Study5:30 Clinical Implications for Facilitators6:47 Final Thoughts

📚 STUDY REFERENCED:Schindler, E. A. D., et al. (2024). "Psilocybin pulse regimen reduces cluster headache attack frequency..." Journal of the Neurological Sciences.

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⚠️ EDUCATIONAL CONTENT DISCLAIMER:This video discusses peer-reviewed research and legally regulated psilocybin programs in Oregon and Colorado. This information is for educational purposes only and should not be considered medical advice. Always consult with a licensed facilitator or health care provider.