Interstitial lung abnormalities (ILA) are changes found on chest CT scans that may represent an early form of interstitial lung disease / pulmonary fibrosis. These interstitial abnormalities may be detected before the onset of respiratory symptoms.

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The definition of these changes is based on international expert consensus, but the current radiological reporting is not always standardized. There is a risk that these incidental changes may get worse over time, but the optimal follow-up is not clear (e.g. how often to repeat the chest CT scans). References related to this video:1. Hatabu H, Hunninghake GM, Richeldi L, Brown KK, Wells AU, Remy-Jardin M, Verschakelen J, Nicholson AG, Beasley MB, Christiani DC, San José Estépar R, Seo JB, Johkoh T, Sverzellati N, Ryerson CJ, Graham Barr R, Goo JM, Austin JHM, Powell CA, Lee KS, Inoue Y, Lynch DA. Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society. Lancet Respir Med. 2020 Jul;8(7):726-737. doi: 10.1016/S2213-2600(20)30168-5. PMID: 32649920; PMCID: PMC7970441.2. Hwang J, You S, Lee YJ, Sun JS. Prevalence and progression rate of interstitial lung abnormalities detected on thoracic CT: a systematic review and meta-analysis. Eur Radiol. 2025 Jan;35(1):276-288. doi: 10.1007/s00330-024-10952-9. Epub 2024 Jul 19. PMID: 39026064.3. Grant-Orser A, Min B, Elmrayed S, Podolanczuk AJ, Johannson KA. Prevalence, Risk Factors, and Outcomes of Adult Interstitial Lung Abnormalities: A Systematic Review and Meta-Analysis. Am J Respir Crit Care Med. 2023 Sep 15;208(6):695-708. doi: 10.1164/rccm.202302-0271OC. PMID: 37534937; PMCID: PMC10515575.#pulmonaryfibrosis #ILA #ild Please leave comments below if you want me to cover other topics in ILD.