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Original Sin

The Genetics of Wrongdoing, the Problem of Blame and the Future of Forgiveness

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 As one of the world's leading scientists examining how our DNA shapes differences in temperament, temptation and behaviour, Harden has seen first-hand how we - in public and in our most private relationships - continue to struggle with the ancient tensions between nature and nurture, freedom and constraint, the desire to punish and the longing to forgive.

In Original Sin, she weaves together insights from her own experience as a daughter, mother, wife and scientist with cutting-edge research in genetics and psychology to grapple with some of the most important questions in modern life: How do we take responsibility for the people we become, knowing how we are shaped by both biology and experience? How should we respond when people hurt each other - or themselves? And has science made guilt obsolete?

Navigating the psychological and biological terrain of addiction, antisocial behaviour and violence, Harden confronts the discomforting ways science unsettles our understanding of wrongdoing and choice. In doing so she asks us not to absolve, but to reckon differently with notions of fairness and blame. A revelatory inquiry into the uneasy space where human behaviour meets inherited biology, Original Sin challenges us to imagine a more humane vision of accountability - for ourselves and for one another.©2026 Sophrosyne Studio LLC (P)2026 Penguin Random House Audio Christianisme Philosophie Psychologie Psychologie criminelle et judiciaire Psychologie et psychiatrie Science

Commentaires

A tour de force. Original Sin is a thoughtful and thought-provoking book that invites us to go deep into questions about why people do terrible things and how we should treat them afterwards. Harden's discussion is deepened by her personal reflections on her own responses to hurt and cruelty - a rare mixture, showing how the scientific and the personal perspective combine in a rich complementarity. I loved this book (GWEN ADSHEAD, author of THE DEVIL YOU KNOW)
A daring, complex, sometimes confounding and ultimately powerful tapestry of a book . . . [moves] with propulsive momentum and elegant logic from dog-training and child-rearing to corporal punishment, mass incarceration and, ultimately, hope for the future
An extraordinary book, the very best of science writing, because it is not just about science, but is memoir, history, bleeding-edge genetics and a completely original take on original sin. Thrilling, entertaining, provocative, brilliant (ADAM RUTHERFORD, author of A BRIEF HISTORY OF EVERYONE WHO EVER LIVED)
A book littered with fascinating scientific findings... Harden is exceptionally skilled at interweaving the personal and the scientific. She writes about her own life experiences - leaving the church, becoming estranged from her parents, the challenges of early motherhood - with rare, dangerous honesty... [A] complex, thought-provoking book. (Sophie McBain)
Original Sin is an ambitious, compact and often moving contribution to the literature at the intersection of genetics and ethics. It is magnificent to have an established scientist such as Harden address social, political, religious and deeply personal issues in the context of scientific work meant for public consumption. The book should serve as a nucleation point for broad, intense and enlightening discussion (Michael A. Goldman)
This is a serious and knotty book... but it can be beautiful. Harden draws movingly on autobiographical material... Ultimately, this is a well-informed attack on an American style of justice that relies on notions of sin and punishment. Harden acknowledges that retribution feels good - we are human. She wants everyone to be accountable for their actions, whatever their genetics. But she calls for rational measures aimed at reducing offending, and for restorative justice over vengeance. For Norway, not Texas. For compassion, not cruelty... A darkly glittering book. (James McConnachie)
What makes Original Sin so readable apart from damned good writing is a sincere and palpable search for the safety of a god in what we're beginning to know. It's not only part of the solution to a human future but a blind date with the meaning of life. Anyone with a beating heart and a hungry mind should eat this up (DBC PIERRE, author of VERNON GOD LITTLE)
A powerful read that stops you dead in your tracks and forces you to think very deeply (SUE BLACK, author of ALL THAT REMAINS)
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