A girl named Rose is riding her new bike near her home in Deadwood, South Dakota, when she falls through the earth. She wakes up at the bottom of a square hole, its walls glowing with intricate carvings. But the firemen who come to save her peer down upon something even stranger: a little girl in the palm of a giant metal hand.

When Rosemary Harper joins the crew of the Wayfarer, she isn't expecting much. The ship, which has seen better days, offers her everything she could possibly want: a small, quiet spot to call home for a while, adventure in far-off corners of the galaxy and distance from her troubled past. But Rosemary gets more than she bargained for with the Wayfarer. The crew is a mishmash of species and personalities, from Sissix, the friendly reptilian pilot, to Kizzy and Jenks, the constantly sparring engineers who keep the ship running. Life on board is chaotic, but more or less peaceful - exactly what Rosemary wants. 

Our universe is ruled by physics, and faster-than-light travel is not possible - until the discovery of The Flow, an extradimensional field we can access at certain points in space-time that transports us to other worlds, around other stars. Humanity flows away from Earth, into space, and in time forgets our home world and creates a new empire, the Interdependency, whose ethos requires that no one human outpost can survive without the others. It's a hedge against interstellar war - and a system of control for the rulers of the empire.

The Ruhar hit us on Columbus Day. There we were, innocently drifting along the cosmos on our little blue marble, like the Native Americans in 1492. Over the horizon came ships of a technologically advanced, aggressive culture, and BAM! There went the good old days, when humans got killed only by each other. So, Columbus Day. It fits. When the morning sky twinkled again, this time with Kristang starships jumping in to hammer the Ruhar, we thought we were saved.

The world will end on Saturday. Next Saturday. Just before dinner, according to The Nice and Accurate Prophecies of Agnes Nutter, Witch, the world's only completely accurate book of prophecies, written in 1655. The armies of Good and Evil are amassing, and everything appears to be going according to Divine Plan. Except that a somewhat fussy angel and a fast-living demon are not actually looking forward to the coming Rapture. And someone seems to have misplaced the Antichrist.