Give My Love to Berlin follows the lives of two gay couples—Tillie and Ruth, and their best friends, James and Ernesto—trying to navigate falling in love, thriving in their community, and coming to terms with the danger they are in just by being who they are.

The novel jumps between the twenties and thirties and the early nineties and a young woman named Thea. Thea is dealing with the onset of her grandmother's dementia, and discovers secrets hidden away that her grandmother never intended for her to uncover. Alternating between Tillie's perspective during the '20s and '30s as the Weimar Republic slowly gives way to a dictatorship and the '90s as the secrets of their history come to light.

In 1927, the beautiful city of Berlin is the gay capitol of the world. Ruth, a performer at one of the nightclubs in the city, and her girlfriend, Tillie, are living their lives and enjoying the freedom of the Weimer Republic. As the '20s come to a close, Tillie watches her father, a prominent lawyer, become more entrenched in the Nazi Party. Working in his law office as his secretary, she meets Joseph Goebbels and Hermann Göring, and becomes convinced that their very lives are in danger as the Nazis take over Berlin one neighborhood at a time.