The most anticipated week of the college football season has arrived, however it has arrived with some unfortunate news for the number one team in the country. Miami's star receiver, Malachi Toney, is out indefinitely with a high ankle sprain. Emily Proud, Brandon Marcello and Richard Johnson discuss how this will impact Miami's season going forward. They also discuss the immediate impact this will have on Saturday's matchup with eleventh-ranked Notre Dame.

Then the crew looks at some of they other massive matchups of the weekend. They predict the Sunday headlines for second-ranked Georgia visiting tenth-ranked Ole Miss, third-ranked Utah hosting ninth-ranked BYU, fifth-ranked Alabama visiting 14th-ranked LSU, sixth-ranked Kentucky visiting 13th-ranked Tennessee, seventh-ranked Texas visiting 18th-ranked Missouri and 12th-ranked Ohio State hosting 23rd-ranked Oregon.

Politics have been at the forefront of the news after this week's mid-term elections, but how might those elections impact college football? Emily, Brandon and Richard look at the future of the College Sports Act. Then, they look at the QB transfer market. How active will it be this season and could we see a name such as Arch Manning enter? Plus, news breaks as Texas running back Hollywood Smothers is reported out for the season.

All of this and more on today's College Football Insiders.

(0:51) - How does Malachi Toney's injury impact Miami?
(3:59) - Does Miami need Toney to make the College Football Playoff?
(5:54) - Is Miami vs. Notre Dame a must-win for Notre Dame?
(9:29) - Picking Miami at Notre Dame
(11:48) - Predicting Sunday's headlines: Georgia at Ole Miss
(14:55) - BYU at Utah: the Holy War
(17:29) - Alabama at LSU
(21:28) - Kentucky at Tennessee
(25:55) - Texas at Missouri
(30:06) - Ohio State at Oregon
(33:40) - Midterms impact on the Protect College Sports Act
(39:37) - How do we protect college sports now?
(44:02) - Breaking: Texas RB Hollywood Smothers out for the season
(45:28) - The QB transfer market: how Arch Manning's decision could reshape it
(47:47) - Which teams need a quarterback? Florida State, Oklahoma, Georgia and more
(52:13) - One more thing: Jason Eck says he might leave New Mexico
(53:00) - One more thing: LSU trying to add Dave Aranda
(54:29) - Could Mike Norvell join a staff midseason?