Couverture de 1 in 20 Women Have PMDD: Why Your Hormone Tests Come Back Normal | The Connection with Autism, ADHD, Endometriosis, PMOS | The Science Behind PMS and PMDD with Neuroscientist Dr Emilė Radytė

1 in 20 Women Have PMDD: Why Your Hormone Tests Come Back Normal | The Connection with Autism, ADHD, Endometriosis, PMOS | The Science Behind PMS and PMDD with Neuroscientist Dr Emilė Radytė

1 in 20 Women Have PMDD: Why Your Hormone Tests Come Back Normal | The Connection with Autism, ADHD, Endometriosis, PMOS | The Science Behind PMS and PMDD with Neuroscientist Dr Emilė Radytė

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Send us Fan Mail"Every Two Weeks You Are No Longer Yourself"Dr Emilė Radytė is a Harvard and Oxford-trained neuroscientist and the co-founder and CEO of Samphire Neuroscience, where she builds neurotechnology for women's health. Her work treats PMS, PMDD and menstrual pain as conditions of the brain, not just the hormones. She was named in Forbes 30 Under 30 for healthcare in 2024.TW: We discuss depression and suicide in this epsiode. 💬 Top quotes"If you live with PMDD, it means every two weeks you are no longer yourself, so you lose literally half of all of your reproductive life.""When most women test their hormones, they find out it's perfectly fine. The reason they have those symptoms is because of how their brains respond to those hormones.""For years, depression was called hysteria in women, and so I think the idea that women could have something specific is already relatively new.""A stable job expects you to show up the same way every day, and is built for a male-like cycle, where women, we know we're not the same every day anyway.""Hormones are just the way that our bodies talk to us, and I think if anyone gets anything from this talk, that should be the key."🧠 The bit nobody explains properlyWhy PMDD is a recognised medical condition, not a bad mood, and how it differs from PMS even when the symptoms overlapWhy most women with PMDD have completely normal hormone levels, and what that really meansThe two weeks before your period, explained: why the part of your brain that regulates emotion goes offline, and why that isn't a character flawWhy women with PMDD often thrive in the first half of their cycle, and can be twice as productive as everyone elseThe woman who writes a resignation letter every single month, and what it tells us about impulsivity in PMDDProgesterone, allopregnanolone and GABA: why a hormone that calms most women can do the opposite for someWhy your pain threshold drops during your period, so you feel more pain and have more to feelWhy it took so long to be taken seriouslyPMDD was only recognised as a depressive disorder in 2014, which means most psychiatrists trained before it existedHow depression in women was once called hysteria, and how long that shadow has beenWhy a diagnosis can still take years, and what makes PMDD so hard to catch in a ten-minute appointmentThe reason your symptoms vanish the week your appointment finally arrives, and what to do about itThe stuff you've probably triedWhether "balancing your hormones" is a real thing, and where the idea goes wrongWhat the evidence actually says about supplements, and whether they reach your brain at allThe pill and PMDD: what it does, what it doesn't, and why options matter more than answersHow brain stimulation works, whether it lasts, and what neuroplasticity really meansThe connections nobody joins upWhy ADHD and PMDD so often show up together, and what's happening in the prefrontal cortexThe link between stress, your brain and the timing of your cycleWhy hormones are the message, not the cause, including in PMOS (PCOS)What we still don't know about PMDD and long-term brain healthThe part that affects your whole lifeWhy so many women with PMDD end up freelancing, and what that says about workplaces built for a body that doesn't changeWhat's happening in women's careers in their 30s, and why senior roles are where it showsIf you think this might be you: the one thing to start doing today, where to find free self-screening tools, and how to walk into your GP's appointment preparedWhy this episode is worth hearing even if you don't have PMDD📊 The research behind the episodePMDD affects around 1 in 20 women, or 3 to 8% depending on the criteria used. Source: Samphire Neuroscience; figure consistent with DSM-5 estimates.In a global study of 599 people with a confirmed PMDD diagnosis, 72% reported suicidal thoughts at some point in their lives, 49% had made a plan, and 34% had attempted suicide during a PMDD episode. Eisenlohr-Moul et al., BMC Psychiatry, 2022. Caveat: participants were self-selected through an online survey, so the sample likely reflects more severe experiences than the wider PMDD population.A 2026 systematic review of 18 studies covering around 2.6 million people found rates of suicidal thoughts in PMDD ranging from 26% to 86%. Zhitnik et al., Administration and Policy in Mental Health. Caveat: the wide range reflects very different study designs and definitions, which is why no single number tells the whole story.Around 41% of women with ADHD screen positive for PMDD. Broughton et al., British Journal of Psychiatry, 2025. Caveat: this is a cross-sectional survey using provisional screening rather than clinical diagnosis, and it measures PMDD among women with ADHD, not the reverse.PMDD was added to the DSM-5 as a depressive disorder in 2013 to 2014, which is why many clinicians trained before then had no formal teaching on it.⚠️ One correction to noteIn the episode, Emilė says 70% of ...
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