Thursdays aren't simply another day of the week for Amy Spencer and Ellis Hall. Thursday afternoons sizzle with no-strings sex for the two women, who meet each week in a hotel room to forget their past - and their present. The arrangement works perfectly for Amy, a busy surgeon who's still smarting from a failed relationship. For Ellis, Thursday afternoons act as a pressure valve from her cutthroat job and mistakes in her personal life she's trying to rectify. Soon they discover that their outside worlds are on a collision course with the carefully constructed world they've created.

Stockbroker Isabelle Rhodes has a lot of money, a lot of trust issues, and a whole lot of reasons to believe her ex-girlfriend was right when she said that Isabelle sucked at relationships. With that accusation stuck in her head, Isabelle throws caution to the wind and dives into her first one-night stand. Checking that off her bucket list should be something to celebrate - except it turns out that the woman she just spent an earth-shattering night with is actually her newly hired company pilot, Audrey Graham. Ms. Never-See-You-Again just turned into Ms. See-You-Constantly.

Jana Fleischer loves her life - wonderful family, best sister in the world, awesome soon to be sister-in-law, fabulous job, and a never-ending stream of men to chew through and spit out. So what if everyone says she’s too picky and she’s never had a real relationship? When a chance meeting with Brooke Donnelly leaves Jana literally and figuratively off-balance, it doesn’t take long for her initial annoyance to turn into the first sparks of friendship.

Captain Sabine Fleischer is a skilled and dedicated US Army surgeon deployed to a combat hospital in Afghanistan. She is also one of the thousands of troops who are forced to serve in silence because of the military's anti-gay policy of "Don't Ask, Don't Tell (DADT)". Usually driven and focused, Sabine finds that battles raging both inside and outside are making it more and more difficult for her to deal with her emotions. Dealing with loss and mortality, lack of privacy, sleep deprivation, loneliness, and the isolation forced on her by Don't Ask, Don't Tell are all taking their toll.

During her morning exercise, yoga instructor Cam Saunders finds herself rescuing a young woman who has walked into the sea, seemingly intent on taking her own life. When the woman in question turns out to be a famous actress, Cam promises to keep her secret safe. Six months later, America’s sweetheart Ella Temperley is working hard to get her life back on track, grieving the loss of her twin sister and fighting a deep depression. Despite her fame, she feels alone in the world and keeps thinking of the woman she owes her life to.

Finley Knight, ex-cop turned private investigator, lives a lonely, solitary life. She uses her downtime to reflect on the past and wonders what could have been. Detective Dee Woodard transferred to Corpus Christi nine years ago to put distance between herself and her ex...an ex she was still in love with. A murder investigation leads her to Moonlight Avenue and Finley Knight. 

Workaholic Detective Aiden Carlisle isn't looking for love - and certainly not at the law-enforcement seminar she reluctantly agreed to attend. But the first lecturer is not at all what she expected. Psychologist Dawn Kinsley has just found her place in life. After a failed relationship with a police officer, she has sworn never to get involved with another cop again, but she feels a connection to Aiden from the very first moment. Can Aiden keep herself from crossing the line when a brutal crime threatens to keep them apart before they've even gotten together?  

Ashleigh Pence had been the all-American high school girl: cheerleader, prom queen...and in love with another girl. Gina Granbury hasn't thought about Calloway High in 20 years, but the arrival of the invitation to the class reunion brings back memories of Ashleigh and the betrayal that drove them apart. With no real choice, Ashleigh has to go the event, hoping that it's not the one reunion that Gina decides to attend after all these years. Gina's curiosity is suddenly strong. Her long-broken heart has never mended, but that's no reason to go back in time...is it?

Homicide detective Tori Hunter was used to doing things her way. But even after six different partners in seven years, she was not prepared for the hot-tempered Samantha Kennedy. Samantha, on the other hand, was trying to juggle a new job and a demanding boyfriend and now finds herself with an even greater challenge - being partnered with the most difficult detective in the entire squad.

When Claire, an overachieving psychologist with OCD tendencies, hires Lana, an impulsive, out-of-work actress for a fake relationship, she figures the worst she'll have to endure are the messes Lana leaves around. It's only for a few months anyway. And it's not as if she'll enjoy all those fake kisses and loving looks. Right?