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Taking a thematic rather than strictly chronological approach, W. F. Bynum, explores the key turning points in the history of Western medicine - such as the first surgical procedures, the advent of hospitals, the introduction of anesthesia, X-Rays, vaccinations, and many other innovations, as well as the rise of experimental medicine. The book also explores Western medicine's encounters with Chinese and Indian medicine, as well as nontraditional treatments such as homeopathy, chiropractic, and other alternative medicines.

In 2007, Lissa Rankin left a promising career in medicine to tend to her own health and well-being. Her search to discover why people really get sick and what truly optimizes health outcomes launched a bestselling book, two television specials, and a revolution in the way we look at mind-body medicine. But so many questions remained for this doctor and skeptic. Certain that, if she looked hard enough, she would find the answers, Dr. Rankin embarked on a decade-long journey to explore these questions and more.