During this episode, Dr John Isaacs and Dr Josh Bennett from Newcastle University and the NIHR Newcastle Biomedical Research Centre, discuss sarcopenia - an age-related loss of muscle mass and strength. Sarcopenia is relatively common in rheumatoid arthritis, with a prevalence ranging from 4·5% to 44% of people with rheumatoid arthritis, depending on the definition of sarcopenia used. Rheumatoid sarcopenia increases the risk of fall, fractures, disability, and hospitalisation. Therefore, prevention and management is important, especially in older patients. We discuss the how and why sarcopenia arises and how it can be managed, as well as the recent publication of the RAMUS study, which looked at the skeletal muscle effects of JAK inhibitor tofacitinib in rheumatoid arthritis. The link to the Nature Rheumatology Review mentioned can also be found below.
RAMUS study: https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(25)00184-5/fulltext
Nature Rheumatology Review: https://www.nature.com/articles/s41584-023-00921-9

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This month's episode covers Sjögren’s disease—an autoimmune condition that primarily affects areas of the body that produce fluids, such as tears and saliva. The cause of the disease isn’t understood. Currently there are no licensed drugs to treat the disease, but phase 2 clinical trials have reported encouraging results, and phase 3 trials are underway.

Dr Samuel Bitoun, from the University of Paris-Saclay and APHP, discusses how Sjögren’s disease is currently classified, the challenges of using such classification, and how AI and deep learning could potentially contribute to this area, which is the focus of his recent study published in The Lancet Rheumatology, which aimed to train a neural network model to perform focus score classification and identify new histological patterns associated with this disease.

Click here to read the full article: https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(25)00181-X/fulltext

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In this episode, we’re tackling a condition that affects over 374 million people worldwide—knee osteoarthritis (OA). As the most common site of OA, knee OA is a leading cause of disability and accounts for more than 12 million disability-adjusted life years globally. With prevalence rising steadily due to aging populations and increasing obesity rates, the burden of knee OA is projected to climb even further in the coming decades.

We speak with the lead author of a new study published in The Lancet Rheumatology, Dr Scott Uhlrich, from the University of Utah. The study offers fresh insights into the management of knee OA through personalised gait retraining. We’ll explore the study’s design, its clinical implications, and what the future might hold for patients with knee OA.

Read the full article:

https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(25)00151-1?dgcid=buzzsprout_icw_podcast_September_25_lanrhe

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