We are living through one of the most significant shifts in medicine in generations, and most people don’t fully understand what it means. Dr. Christle Guevarra joins me to zoom out on the entire GLP-1 landscape; from the drug’s origins as a modest diabetes treatment in 2005 to today’s third-generation medications still moving through clinical trials, and what all of it means for the future of obesity, performance, and longevity.

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Connect with Dr. Christle Guevarra

YouTube: https://bit.ly/4vDMVQa

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⏰Timestamps:

00:00 Intro of Show

06:48 Changes in the Fat Loss Landscape

06:54 Engagement in Competitive Powerlifting

11:29 Perspectives on GLP-1 Medication

26:10 Perimenopause Journey

27:13 Topamax

28:03 Urosepsis

30:23 Weight Loss Programming

31:43 Patients' Decision to Take GLP-1

37:44 Risks and Effects on Taking GLP-1

38:10 Pancreatitis

41:40 Fen-Phen (Fenfluramine/phentermine) / Ephedra

45:59 Who Should Not Take GLP-1?

49:24 Proper Nutrition to Support Taking GLP-1

52:14 Recommendation for the New Dietary Guidelines

59:01 Residency and Sports Medicine Fellowship

1:02:38 Are Athletes Recommended to Take GLP-1?

1:08:49 Lack of Randomized, Controlled Trials for Peptides

1:10:38 Key Take-away's from Dr. Christle

1:13:24 Should Women Weigh Themselves?

1:21:02 Should Women Lift Weights?

1:21:55 What's Next for Dr. Christle?

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.

The moment you decide to show up publicly, you open the door to opinions from people who would never say those things to your face. Dominique Sachse, journalist, author, and content creator who has lived her life on camera for over three decades, gets honest about what it costs to put yourself out there, why online cruelty is a psychology problem more than a content problem, and how “Teflon Dom” developed the thick skin to let none of it redirect her.

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⏰Timestamps:

00:00 ​Intro of Show

02:10 Dominique’s Mission

05:13 Women’s Reinvention with Aging

12:07 Handling People’s Opinions in the Media

18:03 Why Dominique Wrote “Life Makeover”

26:08 Activating One’s Faith through Life’s Challenges

29:16 Decision to Leave the News Business

34:12 Traditional Media Transitioning to Online Media

37:09 How to Curate Information

38:42 Effectively Communicating with Journalism and Research Skills

43:17 Managing Conflicts On-and-Off Air

45:28 The Aging Process

49:53 Personal Training with Body Builders

52:33 Changes in Training and Nutrition

54:49 Importance of Discipline

1:00:28 How Dominique Makes Decisions

1:04:03 Dominique’s Goal and Message

1:08:46 Midlife Wellness Protocols

1:14:29 What’s Next for Dominique?

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.

Only nine scientists were asked to advise on the 2025 Dietary Guidelines for Americans, and Dr. Tom Brenna was one of them. In this conversation, he pulls back the curtain on how dietary guidelines are actually made, why the process has never been the same twice, and what it was like to watch a decades-old saturated fat recommendation get carried forward despite a lack of evidence supporting it at the level of total mortality. This is the dietary guidelines conversation the internet has been missing: straight from someone who was actually in the room.

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LinkedIn: https://bit.ly/4shYfyl

References:

https://nutrition.org/american-society-for-nutrition-calls-for-strong-science-in-national-nutrition-guidance/

https://ajcn.nutrition.org/article/S0002-9165(24)00527-6/fulltext

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⏰Timestamps:

00:00 ​Intro of Show

00:14 Dr. Tom Brenna’s Background

05:19 Working with IBM

08:46 Family Life

10:38 2015 vs. 2025 Dietary Guidelines for Americans

28:06 American Society for Nutrition: Behind-the-Scenes of Dietary Guidelines

32:10 History of Saturated Fat

42:17 Different Types of Fat

45:23 How Are People Eating during World War II

51:09 The Whole Milk for Healthy Kids Act of 2025

53:58 What is Saturated Fat?

57:57 Link between Saturated Fat and Cardiovascular Diseases

1:05:53 Saturated Fat vs. Total Mortality

1:13:13 Best Studies on Saturated Fat

1:14:42 Reduction of Saturated Fat = Lowered LDL Cholesterol

1:22:35 Pregnancy and Fish Consumption Myths

1:37:55 Recommended Nutrition

1:39:59 Different Types of Oil and Effects on Health

1:42:04 Omega 3’s and 6’s Recommendation

1:50:02 Omega 3 Fatty Acids and ADHD

1:50:54 What’s Next: Precision Nutrition and Genetics

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.