Welcome back to STEMCast: Beyond the Lab! In our most interdisciplinary episode to date, we invited Professors Perry Zurn (Department of Philosophy at the American University) and Dani Basset (Department of Bioengineering at the University of Pennsylvania) to discuss their individual research careers and their most prominent topic of collaboration: curiosity. Join us as we learn everything from mathematical models of curiosity to social dilemmas that could benefit from them!

In this episode, we cover:

(01:38) Dani’s scientific curiosities

(4:15) Perry’s scientific curiosities

(7:24) How did you both start working together?

(9:31) Defining curiosity: a type of edge work?

(16:19) How does living in an information-dense age affect how we channel our curiosity?

(18:49) Differences in collective curiosity and inequity in scientific research

(24:00) Curiosity archetypes that will help us tackle ethical dilemmas

(29:37) Mathematics of network modeling and its pitfalls

(32:19) Fuzzy nodes and marbles (not) in the brain!

(42:21) Questions that you guys are looking forward to working on in the future

Further reading

• Read more about Prof. Dani Bassett
• Read more about Prof. Perry Zurn
• Book: Curious Minds: The Power of Connection

Episode host and producer: Sabrina Du and Isabelle Guo

Contact:igem@mcgill.ca

This week on STEMcast, we interview Kyne Santos, renowned math communicator and drag queen, known familiarly on TikTok and Instagram as OnlineKyne. With short content math videos, Kyne explores the mathematical world at all educational levels, all while dressed fabulously in drag! In this episode, we learn more about Kyne, his introduction to both the math and drag worlds, and how he uses his platform to expand access to education. We discuss the importance of scientific communication, the overlaps of art and science, and how queerness and gender interact with the STEM world. To top it off, we throw in our own experiences with synthetic biology, education in iGEM and our own experiences navigating STEM spaces as queer individuals. Tune in for personal stories, humour and new insights into how queer identity and STEM can intersect!

This week on STEMcast, we interview three professionals doing impressive technical and advocacy work across academia and industry, and ask them about their experiences with Diversity, Equity and Inclusion (DEI) in a panel-style format. You'll hear from Aflah Hanafiah, a graduate student researching epigenetics and a prominent advocate working to uplift LGBTQIA+ voices in academia; Mel Rees, an oil and gas systems operator with expertise in the energy sector, who also shares a passion for advocacy and promoting inclusivity in STEM; and Anmol Nagpal, the CEO and co-founder of a start-up specializing in therapeutics for genetic neurological disorders, and a passionate advisor in the biotech start-up sphere.Tune in for inspiring stories, insights on current DEI challenges, and discussions on how we—as students and professionals—can help shape a future where all voices are empowered in STEM spaces.

Welcome to the Beyond the Lab series of STEMcast! Today, AI is helping us understand what allowed us to create it in the first place: our brains. Although the intersection of neuroscience and AI is nothing new, tools that leverage this combination are now making their way from the lab and into consumer markets. What are these tools? Why are they better equipped to analyze neural data, and why are researchers launching entrepreneurial ventures to bring them to life?

In this episode, Adrien Peyrache and Blake Richards, professors at McGill University’s Montreal Neurological Institute and pioneers in the NeuroAI space, join us to discuss their research careers and what led them to co-found Lamarck Labs, a neurotech company building foundation models for neuroscience.

Note: After this episode, this series will be taking a short break. We’re excited to come back in the Fall, refreshed and ready to share more stories beyond the lab.

In this episode we cover:

(01:27) A rave that lead to Blake’s research origins

(04:03) Adrien’s scientific beginnings

(09:05) Scientific collaboration: How did they meet and start working together?

(14:53) Why are AI systems better at “decoding the brain”?

(19:59) Entrepreneurial collaboration: Founding Lamarck Labs

(25:58) Why now? Using foundations models in neuroscience

(31:35) Applications of foundation models in Lamarck Labs

(37:00) What excites and worries both professors about the future of this technology.

Further reading/listening

• Read more about Prof. Adrien Peyrache here
• Read more about the Peyrache Lab
• Read more about Prof. Blake Richards here
• Read more about LiNC Lab
• Read more about Lamarck Labs here
• Papers, essays and other media that we mentioned:
  • Paper: Sequential Predictive Learning is a unifying theory for hippocampal representations and replay
  • SuperDataScience Podcast with John Krohn
  • Adrien Peyrache’s Amazing Brain Science Talk
  • Blake Richards’ Amazing Brain Science Talk

Host and producer : Sabrina Du

Contact: igem@mcgill.ca

Welcome to the Beyond the Lab series of STEMcast! With Prof. Andrew Millis, Professor of Physics at Columbia University and co-director of the Center for Computational Quantum Physics at the Flatiron Institute, we dive into the fundamental and fundamentally strange world of quantum mechanics and how it is connected to the world of everyday things. How do collective properties arise from the interaction of individual atoms and electrons? How is the whole different from the sum of its parts? Alongside these questions, we discuss the origins of the Simons Foundation and its internal research division, the Flatiron Institute. Prof. Millis describes the philosophy of philanthropy-driven science at Flatiron, how it differs from traditional academic funding models, and how it fosters a culture of collaboration. Thanks to this culture, the whole can truly go beyond the sum of its parts.

Note: At 3:30-4:51, there is a difference in audio quality. Our sincerest apologies!

In this episode, we cover:

(01:21) What is quantum condensed matter physics?

(5:15) Simons Foundation and the Flatiron Institute

(12:54) Funding models for long-term projects

(16:21) A culture of collaboration at the Flatiron

(20:03) Interdisciplinary vs. deep domain expertise

(24:25) Sharing a “common language” between fields

(30:20) Picking up the basics of mathematics and physics

(33:06) Philanthropic funding

Further reading/listening

• Read more about Prof. Andrew Millis
• Read more about the Simons Foundation
• Read more about the Flatiron Institute

Episode host and producer: Sabrina Du

Contact: igem@mcgill.ca

Welcome to the Beyond the Lab series of STEMcast! This week, we are joined by Matthew Cobb, Professor of zoology (Professor Emeritus) at the University of Manchester, historian and author. From the discovery of the double helix to the 1975 Asilomar conference on recombinant DNA, we explore various historical events that shaped public perception of the life sciences and talk about how the history of science can help explain disruptive technologies. Through these discussions, Prof. Cobb draws our attention both to the scientist(s) that made the discovery and to the discovery that made the scientist(s). Is there more to the connection that binds the two?

Note: Many readings and resources were mentioned during this episode. Please find links to all of them below.

In this episode we cover:

(01:11) Origin of Prof. Cobb’s research interests

(07:29) A Second Hat: Prof. Cobb as a Historian

(11:38) Public opinion shaping life sciences discoveries and vice-versa

(14:44) Using history to communicate disruptive technologies

(21:58) How a scientific background positions you as a historian: His experience with Rosalind Franklin Archives

(25:37) Tug-of-war between scientific advancement and ethical concerns

(30:22) Protecting ethical science in a publish or perish culture

(34:41) Using history to communicate the importance of foundational advances: The Story on PCR and CRISPR

(37:39) The discovery versus the individual who discovered: Watson Crick and the discovery of the double helix

Further reading/listening

• Read more about Prof. Matthew Cobb
• Listen to Prof. Cobb’s 2024 Wilkins-Bernal-Medawar Prize Lecture
• View annotated copies of Rosalind Franklin’s DNA notebooks
• Extended show notes

Books mentioned:

• The Double Helix: A Personal Account of the Discovery of the Structure of DNA (James Watson)
• The Astonishing Hypothesis: The Scientific Search for the Soul (Francis Crick)
• As Gods: A Moral History of the Genetic Age ((Matthew Cobb)
• Crick: A Mind in Motion (Matthew Cobb)

Episode host and producer : Sabrina Du

Contact: igem@mcgill.ca

Welcome to STEMCast: Beyond the Lab, a series where we explore the many hats that scientists wear. From professors embarking on entrepreneurial journeys to researchers involved in policy making, join us as we explore both inside and beyond the lab.

With Dr. Shari Wiseman, Chief Editor at Nature Neuroscience, we peer into her journey from the lab bench to the editor's desk, and how that transition gave her a broad view of scientific progress in neuroscience. Dr. Wiseman shares her perspective on the future of the field, explains how her team identifies and nurtures emerging research, and describes the responsibility of curating a journal that sets global research standards. From the art and science of publishing to the importance of listening to your emotions as a student, this conversation is filled with practical wisdom for scientists at every stage.

In this episode, we cover:

(00:40) Dr. Wiseman’s research background and appreciation for lab culture

(4:28) How did her interest in scientific editing emerge?

(8:20) Finding excitement and fulfillment as Chief Editor at Nature Neuroscience

(12:49) Curating Nature Neuroscience

(16:27) Creativity in science publishing and shaping the field

(21:46) Current and emerging trends in neuroscience

(28:08) Paradigm shifts in neuroscience

(32:14) Open science

(36:13) The future of neuroscience and neuroscience publishing

(39: 52) Advice for students

Further reading

• Read more about Dr. Shari Wiseman
• Read Nature Neuroscience’s July Issue
• Nature Neuroscience is hiring!

Episode host and producer: Sabrina Du

Contact: igem@mcgill.ca

Dr. Peter Grutter, a physicist studying and developing atomic force microscopy (AFM), takes this episode to walk us through the varying facets of his work. We begin by understanding how manipulating the properties of nanoscale materials can alter their behaviours in ways unintuitive to us macro-scale beings, despite them following the same basic universal ruleset as everything else: physics. The episode continues to explore Dr. Grutter’s work, which involves using AFM to measure Nanonewton-scale forces or evaluate the shape of Nanometer-scale objects. He explains how this cutting-edge tool is applicable to a plethora of fields, including microbiology. Tune in to learn how physics is contributing to the fight against cancer at scales smaller than an atom!