In this episode, Elizabeth Tringali sits down with Dr. Matt Kaeberlein, a leading aging researcher focused on the mechanisms that drive aging, including mTOR signaling and the drug rapamycin.

Matt breaks down what mTOR actually is (and why it matters), why longevity medicine requires evidence and comfort with uncertainty, and what we can realistically conclude from animal data vs. human data. You’ll hear a clear, science-first conversation on rapamycin: immune modulation vs. “immune suppression,” common side effects, why weekly dosing is different than transplant dosing, and what early findings suggest for APOE4 carriers, post-viral syndromes like long COVID, and chronic inflammation.

They also zoom out to the foundations Matt believes move the needle most: the four pillars he uses at OptiSpan (eat, move, sleep, connect), plus practical guidance on protein, fiber, CGMs, and why fear-based wellness marketing is a problem. Finally, Matt shares an update on the Dog Aging Project’s randomized rapamycin trial—one of the most fascinating real-world studies in the field—and what he expects the next 20 years of longevity medicine to look like.

Learn More about Dr. Matt Kaeberlein's research at Optispan.life

Learn More about the Dog Aging Project

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In this episode, Elizabeth Tringal, PA-Ci is joined by Dr. Leonard Pastrana and Dr. Frank Kacou, founders of NubioAge and NuHX, to go deep into what truly separates exceptional compounding pharmacies from the rest.

They break down how compounded therapies support personalization in ways conventional pharmaceuticals can’t, from micro-dosing GLP-1s to creating cleaner hormone formulas, mitochondrial peptides, and nasal therapies that dramatically improve absorption. The conversation dives into why testing standards matter, how pharmaceutical-grade vs food-grade ingredients change outcomes, and why waiting on backorders often means your pharmacy is doing things right.

A major focus is long COVID and the accelerated aging providers are seeing: brain fog, immune dysfunction, fatigue, kidney stress, and metabolic decline. Leonard and Frank explain why most protocols start with the gut, how spike protein may be hiding in the microbiome, and why mitochondrial repair is central to recovery. They discuss stacks involving peptides, methylene blue, NAD, tryptophan, butyrate, and gut-supportive compounds that clinicians are using right now.

You’ll also hear:

• Why nasal delivery can outperform oral dosing for certain therapies
• How methylene blue supports mitochondrial energy and cognitive clarity
• The difference between hydration and true cellular hydration
• What “mitochondrial flexibility” means and how it’s measured
• Why exercise tolerance is one of the strongest markers of brain recovery
• How dosing errors derail otherwise perfect protocols
• Why compounding allows medicine to meet the patient, not the other way around

This episode is a masterclass in how functional medicine, pharmacy, and longevity science intersect—and why compounding is not something to fear, but something to understand deeply and use intelligently.

Links:

• Nubioage: a longevity science and wellness education network serving medical practitioners and allied health professionals focused on delivering patient-centric, evidence-based longevity medicine.
• NuHX: Advanced, comprehensive metrics and health data analysis.

Products Mentioned:

• Icell Water
• Sytrinol LNA
• AKG
• Peptides at Tringali Vibrant Health

Tringali Vibrant Health Website

Tringali Vibrant Health Online Supplement Store

In this episode of Root Causes, Vibrant Health, Elizabeth Tringali sits down with Bizzie Gold, tech founder, behavior futurist, and one of the most disruptive voices in modern psychology.

Bizzie is the inventor of Predictive Mind, a behavior and thought-prediction technology proven to be 98.3% accurate, designed to decode the subconscious patterns that drive human perception, emotional response, and decision-making. Her work offers a radical, data-driven alternative to traditional mental health models—one that replaces narrative therapy and self-reporting with objective pattern recognition and predictive insight.

A #1 best-selling author in Neuropsychology for Your Brain Is a Filthy Liar, Bizzie exposes the hidden mechanisms that keep people trapped in cycles of self-sabotage, emotional chaos, conflict, and burnout. Her methodology fuses data science, neuropsychology, and large-scale pattern mapping to deliver sustainable brain rewiring—without emotional dependency, indefinite therapy, or symptom-chasing.

In this conversation, Elizabeth and Bizzie connect mental health, trauma, autoimmune disease, inflammation, menopause, GLP-1s, and nervous-system regulation—revealing why treating the body without correcting distorted perception often leads to incomplete or temporary healing.

Together, they explore why:

• Mental illness is rooted in distorted perception, not behavior
• Awareness alone does not change patterns
• Early childhood wiring (ages 2–5) shapes lifelong mental and physical health
• Predictable brain patterns—not personality flaws—drive anxiety, OCD, and self-sabotage
• True healing requires structure, accuracy, and sustainability—not endless processing

Bizzie’s ability to decode human behavior in real time and deliver immediate, actionable solutions has made her a sought-after authority across mental health, technology, and behavioral science.

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Social links for Bizzie Gold:

https://www.instagram.com/bizziegold/

https://www.linkedin.com/in/bizziegold/

https://x.com/bizziegold

https://www.youtube.com/@BizzieGoldOfficial

Links for Tringali Vibrant Health:

tringali-health.com

https://www.instagram.com/tringalihealth/

https://www.facebook.com/TringaliHealth/