Épisodes

  • 50: How Biostatistics Expertise Led to a Career of Propelling Ethical Clinical Trial Design: D. Ross Camidge, MD, PhD; and Tom Fleming, PhD

    50: How Biostatistics Expertise Led to a Career of Propelling Ethical Clinical Trial Design: D. Ross Camidge, MD, PhD; and Tom Fleming, PhD
    Dec 24 2025
    How This Is Building Me, hosted by world-renowned oncologist D. Ross Camidge, MD, PhD, is a podcast focused on the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life’s experiences.

    In this episode, Dr Camidge sat down with Tom Fleming, PhD, a professor of biostatistics at the University of Washington School of Public Health in Seattle.

    Drs Camidge and Fleming discussed how Fleming's interest in biostatistics led to a multifaceted career in clinical trial design and analysis. Fleming pursued a PhD in math and statistics and spent his early career learning to bridge quantitative sciences with clinical medicine, working on landmark trials for adjuvant colon cancer and debunking megadoses of Vitamin C as a cancer treatment.

    A primary focus of Fleming’s career was pioneering the use of Data Monitoring Committees (DMCs) in oncology research to safeguard patient interests and trial integrity, later convincing organizations like SWOG to adopt DMCs to prevent premature data releases and biases. He also co-developed the O'Brien-Fleming monitoring boundary, a statistical framework that allows trials to stop early for efficacy only when the signal is undeniably compelling, thereby protecting scientific rigor.

    After moving to the University of Washington, Fleming expanded his focus into infectious diseases. He led international efforts that revolutionized HIV/AIDS prevention, including demonstrating a reduction in heterosexual transmission of the disease through antiretrovirals and significantly reducing mother-to-child transmission in resource-limited settings.

    Fleming remains a staunch advocate for confirmatory trials and the use of overall survival as the "gold standard" end point, often expressing skepticism toward surrogate biomarkers like progression-free survival. In the episode, he emphasized that rigorous science is possible even in the most challenging environments, provided there is a commitment to clinical equipoise and high patient retention. Outside of his professional life, Fleming prioritizes family and coaches youth soccer teams, reflecting his belief in the power of collaboration.
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    1 h et 11 min
  • 49: How Compelling Communication Makes Early Cancer Detection Part of Everyday Life: With D. Ross Camidge, MD, PhD; and Keith Singer

    49: How Compelling Communication Makes Early Cancer Detection Part of Everyday Life: With D. Ross Camidge, MD, PhD; and Keith Singer
    Dec 10 2025
    How This Is Building Me, hosted by world-renowned oncologist D. Ross Camidge, MD, PhD, is a podcast focused on the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life’s experiences.

    In this episode, Dr Camidge sat down with Keith Singer, the founder and executive director of Catch It In Time.

    Camidge and Singer discussed how Singer's background in broadcasting and cable television has led to a career in promoting cancer awareness. Although Singer initially wanted to be an astronaut, a decline in aerospace engineering jobs during the 1970s and a love for the technical side of high school theater led Singer toward television. He left college early and started his career in Cincinnati, first running a boom microphone and later directing newscasts. Singer explained the career hurdles he faced, noting that they led to opportunities for him to hone his skills and exercise creative freedom.

    In the mid-1980s, a project involving a new pacemaker sparked Singer's interest in using video for health care education. This fascination led him to co-create an innovative platform that broadcast medical programming for physician continuing medical education. Driven by seeing friends and family struggle with cancer, Singer founded the nonprofit Catch It In Time in 2011. His key communication strategy is that cancer should be the supporting actor, not the lead, allowing stories to appeal to targeted audiences based on their hobbies or professions, with cancer awareness as the secondary message.

    Catch It In Time is currently developing The User's Guide to Oncology, a software-based program that uses gaming technology to guide patients with lung cancer, providing essential information to help them have better conversations with their care teams. Singer stressed the importance of short video content for garnering views for this type of content.

    Notably, Catch It In Time recently produced a song titled "Breathe Again" by Lilliana De Los Reyes. "Breathe Again" can be found on all major streaming platforms, and all proceeds are dedicated to cancer awareness and research.
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    1 h et 4 min
  • 48: How An Interest in Translational Research and Drug Development Helps Evolve Regulatory Practices: With D. Ross Camidge, MD, PhD; and Gideon Blumenthal, MD

    48: How An Interest in Translational Research and Drug Development Helps Evolve Regulatory Practices: With D. Ross Camidge, MD, PhD; and Gideon Blumenthal, MD
    Nov 26 2025
    How This Is Building Me, hosted by world-renowned oncologist D. Ross Camidge, MD, PhD, is a podcast focused on the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life’s experiences.

    In this episode, Dr Camidge sat down with Gideon Blumenthal, MD, vice president of Clinical Development Oncology at Merck in Silver Spring, Maryland.

    Drs Camidge and Blumenthal discussed Dr Blumenthal's experience serving on both sides of the oncology regulatory divide. Though initially leaning toward humanities during his education, he pursued a career in medicine. During medical school, he shifted his focus from neuroscience to oncology due to the field’s high unmet need, fascinating drug development pathways, and the intensity of patient interaction. He chose to complete his hematology and oncology fellowship at the National Cancer Institute to immerse himself in translational oncology and drug development.

    Before joining industry, Dr Blumenthal also spent several years working for the FDA. He started there as a medical officer, focusing on all facets of drug development, from ethics and manufacturing to trial design and biostatistics. He emphasized that success at the FDA involves both approving effective agents and identifying drugs that do not work, maintaining transparency through venues like the public Oncologic Drug Advisory Committee meetings. He used FDA data to conduct independent meta-research, such as analyzing the correlation between response rates and overall survival in lung cancer. His proudest achievement at the FDA was helping to establish the Oncology Center of Excellence, which unified drug development reviews across different centers within the agency.

    Dr Blumenthal left the FDA in early 2020, seeking to gain direct experience in developing new therapeutics. Joining Merck, he first worked in regulatory affairs, navigating international regulations in addition to US filing procedures, which are typically prioritized in oncology. He later transitioned into clinical development, and currently focuses on new assets as Merck evolves its pipeline beyond pembrolizumab (Keytruda). Dr Blumenthal concluded that he is excited by the future of oncology, anticipating radical changes driven by new modalities and advanced biomarkers like artificial intelligence–driven digital pathology.
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    55 min
  • 47: How a Career Dedicated to Patient Connections and Research Advances Has Improved Lung Cancer Care: With D. Ross Camidge, MD, PhD; and Mark Socinski, MD

    47: How a Career Dedicated to Patient Connections and Research Advances Has Improved Lung Cancer Care: With D. Ross Camidge, MD, PhD; and Mark Socinski, MD
    Nov 12 2025
    How This Is Building Me, hosted by world-renowned oncologist D. Ross Camidge, MD, PhD, is a podcast focused on the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life’s experiences.

    In this episode, Dr Camidge sat down with Mark Socinski, MD, a medical oncologist and the executive medical director of the AdventHealth Cancer Institute in Orlando, Florida.

    Drs Camidge and Socinski discussed the highlights of Dr Socinski's career trajectory, as well as the personal influences that helped him arrive where he is today. Socinski describes himself as a clinician and clinical investigator with 35 years of focus on lung cancer. His role as executive director of the AdventHealth Cancer Institute involves maintaining an active clinic 1 day a week and dedicating the rest of his time to administrative duties, including recruitment and building infrastructure at the institution.

    In the interview, Dr Socinski explained that he was influenced to enter a career in medicine because of role of the family practitioner he knew growing up. He went on to receive undergraduate and medical degrees from the University of Vermont in Burlington. After training at Dana-Farber Cancer Institute in Boston, Massachusetts, he began his career in private general oncology practice in Vermont before seeking a more academic, subspecialty environment. He joined the University of North Carolina to concentrate on lung cancer, where he pioneered dose-escalation trials using conformal radiotherapy.

    Dr Socinski then described his move to the University of Pittsburgh Medical Center in Pennsylvania. There, he became the chair of the lung pathway, which limits treatment options to a single, expert-agreed standard of care based on efficacy, toxicity, and cost, thus reducing treatment heterogeneity and controlling costs.

    Thereafter, Dr Socinski moved to AdventHealth, attracted by the institution's goal to achieve National Cancer Institute designation and build a major cancer program. Dr Socinski shared that he finds it gratifying to care for patients and lead the development of the institute.
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    1 h et 2 min
  • 46: How a Career of Hearing and Amplifying Patient Voices Has Reached the Pinnacle of Patient Advocacy: With D. Ross Camidge, MD, PhD; and Ken Culver, MD

    46: How a Career of Hearing and Amplifying Patient Voices Has Reached the Pinnacle of Patient Advocacy: With D. Ross Camidge, MD, PhD; and Ken Culver, MD
    Sep 10 2025
    How This Is Building Me, hosted by world-renowned oncologist D. Ross Camidge, MD, PhD, is a podcast focused on the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life’s experiences.

    In this episode, Dr Camidge sat down with Ken Culver, MD, the director of Research and Clinical Affairs at ALK Positive Inc.

    Drs Camidge and Culver discussed the highlights of Dr Culver's career, which has been shaped by clinical practice, research, industry leadership, and patient advocacy. They noted elements of ALK Positive that set it apart from other patient advocacy groups, including its being entirely created, funded, and led by patients with stage IV lung cancer and their caregivers. Culver explained how he collaborates with patients to expand treatment opportunities, meets with companies and universities worldwide, and helps stakeholders recognize both the unmet needs and financial incentives for developing therapies for ALK-positive lung cancer.

    Culver detailed his path to the oncology field, which began with an intention to practice as a community pediatrician in Iowa. This led him to pursue residency training in California, where he gained diverse clinical experience, particularly in HIV/AIDS at the height of the epidemic. His early research explored HIV transmission in children born to drug-using mothers, highlighting the immunosuppressive effect of drug abuse even in the absence of HIV. During his fellowship, he contributed to pioneering work in gene therapy. He also participated in research that laid the groundwork for tumor-directed therapies, which later influenced large-scale clinical trials.

    Eventually, Culver explained that transitioned to industry. At Novartis, he contributed to the development of important drugs and witnessed the transformative launch of imatinib (Gleevec), one of the first targeted cancer therapies. Alongside his professional work, Culver established the Foundation for Peace, a nonprofit providing medical and community support in the Dominican Republic, Haiti, and Kenya. This initiative, which began with a mission trip in 1989, has grown to involve hundreds of volunteers annually, offering both medical care and broader community services.

    In his current role with ALK Positive, Culver noted that he has leveraged patient-led advocacy to influence industry priorities, resulting in several new clinical trials for ALK-positive patients. His work emphasizes balancing discovery research with near-term clinical opportunities to directly benefit patients with cancer today. He also shared how he prioritizes tools to empower patients, such as clinical trial finders, and stressed the importance of having contingency plans before disease progression. Overall, this conversation highlights a career that reflects a consistent commitment to science, patient care, and global service, guided by both professional and humanitarian values.
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    1 h et 8 min
  • 45: How Health Economics Leverages Clinical Research to Advance Patient Care: With D. Ross Camidge, MD, PhD; and Adam Lee

    45: How Health Economics Leverages Clinical Research to Advance Patient Care: With D. Ross Camidge, MD, PhD; and Adam Lee
    Aug 20 2025
    Camidge and Lee discussed Lee's professional journey and personal insights gained from years of working at the intersection of clinical research and patient care.
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    1 h et 11 min
  • 44: How Passion for Healing and Health Care Equity Expands Access to Innovative Therapies: With D. Ross Camidge, MD, PhD; and Brandon Blue, MD

    44: How Passion for Healing and Health Care Equity Expands Access to Innovative Therapies: With D. Ross Camidge, MD, PhD; and Brandon Blue, MD
    Jul 30 2025
    Drs Camidge and Blue discussed Dr Blue’s journey into practicing medicine that led him to his current specialty: the management of malignant hematologic conditions.
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    50 min
  • 43: How Enthusiasm for Science and Global Change Culminates in Wide-Reaching Opportunities to Improve Cancer Care: D. Ross Camidge, MD, PhD; and Catharine Young, PhD

    43: How Enthusiasm for Science and Global Change Culminates in Wide-Reaching Opportunities to Improve Cancer Care: D. Ross Camidge, MD, PhD; and Catharine Young, PhD
    Jul 9 2025
    How This Is Building Me, hosted by world-renowned oncologist D. Ross Camidge, MD, PhD, is a podcast focused on the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life’s experiences.

    In this episode, Dr Camidge sat down with Catharine Young, PhD, who is currently a senior fellow at the Harvard T. H. Chan School of Public Health. Young was formerly the assistant director of Cancer Moonshot Policy and International Engagement in the White House Office of Science and Technology Policy in Washington, DC.

    Camidge and Young, a South African–born scientist, discussed Young's journey from Johannesburg to Charlotte, North Carolina. Young shared that after undergrad, where she majored in biology, she joined a post-baccalaureate fellowship at the National Institute of Alcoholism and Alcohol Abuse, sparking her passion for research. This led her to pursue a PhD in biomedical sciences at the University of Missouri, focusing on the brain’s role in regulating blood pressure. Catherine noted the challenges of changing labs mid-PhD and her eventual decision to step away from academia.

    During her postdoc, Young was inspired by her advisor's science policy fellowship, leading her to pursue a fellowship herself. She was matched with the US Department of Defense, working on chemical and biological threat reduction in former Soviet states and West Africa during the Ebola outbreak. Though she described the experience was eye-opening, she eventually shifted career paths, realizing that long-term government work wasn’t the right fit for her career goals.

    From there, Young worked for the British Embassy in Washington, DC, bridging UK and US science priorities. She then joined the Biden Cancer Initiative, continuing the Cancer Moonshot’s momentum through its ups and downs. Young reflected on how her variety of experiences led her to launch the Cancer Moonshot to new heights as she worked to advance cancer research and patient care through cancer-related policy and global engagement. Young concluded by highlighting her passion for continuing to expand medical treatment access worldwide.
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    1 h et 9 min