What is an EGFR mutation — and could you pass it down to your children? Patient advocate Lysa Buonanno asks the questions every EGFR-positive lung cancer patient wants answered. Dr. Alice Berger, a lung cancer researcher at Fred Hutch Cancer Center, explains how EGFR mutations develop, why they are rarely inherited, and what targeted treatments — including exciting new FDA-approved options — mean for patients today.

Whether you are newly diagnosed or supporting a loved one, this conversation will help you understand your biomarker results, know what to ask your doctor, and feel empowered by the science moving forward on your behalf.

Topics covered:

· What EGFR mutations are and how they develop · Whether EGFR mutations can be passed to children · The role of family history and genetic testing · Risk factors including radon, pollution, and smoking · Targeted therapies like osimertinib (Tagrisso) · New FDA-approved treatments for EGFR exon 20 mutations · Ongoing research into hereditary lung cancer risk

Guests:

Lysa Buonanno, Patient Advocate Dr. Alice Berger, Associate Professor, Fred Hutch Cancer Center

Show Notes - https://lcfamerica.org/wp-content/uploads/2026/04/LCFA-EGFR-Positive-Lung-Cancer-Show-Notes.pdf

Transcript - https://lcfamerica.org/wp-content/uploads/2026/04/LCFA-HWA-EGFR-Positive-Lung-Cancer-Transcript.pdf

Watch Video - https://youtu.be/izHAxxwZVL4

Subscribe to Hope With Answers: Living With Lung Cancer podcast for future episodes on your favorite listening platform.

Join LCFA's social media communities for support and information. Facebook | Twitter | Instagram | YouTube

Clinical trials can feel intimidating, but they are one of the most important ways new lung cancer treatments become available to patients. In this episode of Hope With Answers: Living With Lung Cancer, patient advocate Wendy Brooks sits down with Dr. Ashish Saxena, thoracic medical oncologist at Weill Cornell Medicine, to break down what clinical trials really are and why they matter.

Together, they discuss when patients should ask about clinical trials, what to expect when participating, and common misconceptions — including the fear of being a “guinea pig.” Dr. Saxena explains how clinical trials are carefully designed, closely monitored, and often provide access to promising new therapies earlier in the treatment journey.

You’ll learn:

• What clinical trials are and how they work
• Why timing matters and why you should ask early
• What patients actually receive in a clinical trial
• How clinical trials are improving outcomes in lung cancer
• What questions to ask your doctor

Whether you’re newly diagnosed or exploring your options, this conversation offers clear, practical insight to help you better understand clinical trials and your role in the decision-making process.

Show Notes: https://lcfamerica.org/wp-content/uploads/2026/04/LCFA-HWA-Clinical-Trials-Show-Notes-2026Spring.pdf

Transcript: https://lcfamerica.org/wp-content/uploads/2026/04/LCFA-HWA-Clinical-Trials-Transcript-2026Spring.pdf

Watch Video: https://youtu.be/kBfh8EAGey8

To learn more about clinical trials and download the free toolkit, visit https://lcfamerica.org/trials.

If you've heard the term "SubQ" at your oncology appointment and weren't sure what it meant, this episode is for you. Lung cancer patient and LCFA Speakers Bureau member Stephanie Williams sits down with Dr. Coral Olazagasti, medical oncologist at the Sylvester Comprehensive Cancer Center in Miami, to break down what subcutaneous (SubQ) treatment really means — and why it's making a real difference in the daily lives of lung cancer patients.

Together, they explore how SubQ injections work, how they compare to traditional IV infusions, and the quality-of-life benefits patients are experiencing: shorter clinic visits, no IV access required, less anxiety, and more time back in their day. Dr. Olazagasti also shares the exact questions patients should be asking their doctors to find out if a SubQ option is available for their treatment.

Whether you're newly diagnosed or years into treatment, this conversation is a reminder that you have more options than you may realize — and that asking questions is always the right move.

To learn more about SubqQ and download the free toolkit, visit https://lcfamerica.org/subq.

Show Notes: https://lcfamerica.org/wp-content/uploads/2026/03/LCFA-HWA-What-Is-SubQ_-Show-Notes.pdf Transcript: https://lcfamerica.org/wp-content/uploads/2026/03/LCFA-HWA-Subq-Treatments-Transcript.pdf Watch Video: https://youtu.be/aQwv_ODlXs4

Subscribe to the Hope With Answers: Living With Lung Cancer podcast for future episodes on your favorite listening platform.

Apple Podcasts | Spotify | Amazon Music | iHeart

Join LCFA's social media communities for support and information. Facebook | Twitter/X | Instagram | YouTube