In this episode I explain dog genetics to my friend, comedian Zach Jobe. The story of how dogs became what they are today is a two stage process beginning with the ancient and gradual domestication of dogs from wolves and breeding based of jobs such as herding, hunting or guarding. Then modern dog breeding practices changed the landscape completely and rapidly resulting in some weird genetic quirks that give us the lovable little sweethearts that we know today.

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Created by: Ryan Pevey at evolio.org and Zach Jobe @zhjobe

Concept: A science and comedy converstion about dementia and how it impacts people and society, as well as bold predictions of event that may or may not happen this year, based on scientific skepticism.

Tools: DaVinci Resolve, GIMP

Intro music by Maksym Malko from Pixabay (pixabay.com/music/upbeat-podcast-interview-music-254186/)

Podcast streams:

redcircle.com/shows/04ecc7a3-3383-4ca0-bff3-c55d04100ed5

podcasts.apple.com/us/podcast/hidden-science-stories/id1874450380

open.spotify.com/show/50xaIb6jjmSJv7georpfVt?si=16e6c0e030414593

music.amazon.com/podcasts/b0415a99-f209-4c66-80c5-d8eb2b490811/hidden-science-stories

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Citations:

vonHoldt et al. (2010) , "Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication." Nature 464:898–902. DOI: 10.1038/nature08837.

Bergström et al. (2022) , "Grey wolf genomic history reveals a dual ancestry of dogs." Nature 606:313–320. DOI: 10.1038/s41586-022-04824-9.

Savolainen et al. (2002) , "Genetic evidence for an East Asian origin of domestic dogs." Science 298:1610–1613.

Thalmann et al. (2013) , "Complete mitochondrial genomes of ancient canids suggest a European origin of domestic dogs." Science 342:871–874.

Parker et al. (2004) , "Genetic structure of the purebred domestic dog." Science 304:1160–1164.

Parker et al. (2017) , "Genomic analyses reveal the influence of geographic origin, migration, and hybridization on modern dog breed development." Cell Reports 19:697–708. DOI: 10.1016/j.celrep.2017.03.079.

0:00 An ancient friend

4:47 A tale in two parts

14:00 The modern dog breeding era

21:31 Genetic bottlenecks and founder effects

27:48 An ideal genetic model

38:02 Ethics of animal research

46:23 Dog genetic testing

55:26 Addendums and errata

57:36 Donut labs prediction update

1:03:41 Outro

In this episode I explain dementia to my friend, comedian Zach Jobe. Starting with a personal story about my grandmother, we explore what dementia actually is, the different types of dementia, and how they present for patients and caregivers. We cover the latest research and why recognizing cognitive decline matters more than ever. Following that we make predictions for 2026, using only our scientific knowledge and critical thinking skills.

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Created by: Ryan Pevey at evolio.org and Zach Jobe @zhjobe

Concept: A science and comedy converstion about dementia and how it impacts people and society, as well as bold predictions of event that may or may not happen this year, based on scientific skepticism.

Tools: DaVinci Resolve, GIMP

Music by Maksym Malko from Pixabay (pixabay.com/music/upbeat-podcast-interview-music-254186/)

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0:00 Let me tell you about my grandmother

3:15 The different types of dementia

22:23 A surprising connection to dementia

27:06 Annual predictions 2026

27:55 Prediction 2: DJT has end-stage dementia

36:01 Prediction 2: the AI bubble will burst

38:22 Prediction 3: DONUT labs will be revealed a fraud

57:27 Moonshot prediction: Betelgeuse will go Supernova

63:41 Outro

In this episode I explain peanut allergies to my friend, comedian Zach Jobe. Peanut allergy rates tripled over the first decade of this century, so we cover the evidence showing why, and how they were successfully brought back down to historical levels using the process of science and evidence based healthcare policy.

Open data fuels open science.

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Created by: Ryan Pevey at evolio.org and Zach Jobe @zhjobe

Support my work and keep it sustainable: ko-fi.com/evolio

Concept: A funny science and comedy story about how a well meaning peanut avoidance recommendation helped spike peanut allergies, and how evidence-based medicine helped bring them back down.

Tools: DaVinci Resolve, GIMP

Music by Maksym Malko from Pixabay (pixabay.com/music/upbeat-podcast-interview-music-254186/)

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Citations:

Du Toit G, et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol. 2008 Nov;122(5):984-91. doi: 10.1016/j.jaci.2008.08.039. PMID: 19000582.

Du Toit G, et al. Early peanut introduction for allergy prevention: Follow-up to adolescence. NEJM Evidence DOI: doi.org/10.1056/EVIDoa2300311 (2024).

Du Toit G, et al; Immune Tolerance Network LEAP-Trio Trial Team. Follow-up to Adolescence after Early Peanut Introduction for Allergy Prevention. NEJM Evid. 2024 Jun;3(6):EVIDoa2300311. DOI: doi.org/10.1056/EVIDoa2300311. Epub 2024 May 28. PMID: 38804779.

Stanislaw J. Gabryszewski, Jesse Dudley, Jennifer A. Faerber, Robert W. Grundmeier, Alexander G. Fiks, Jonathan M. Spergel, David A. Hill, Guidelines for Early Food Introduction and Patterns of Food Allergy, Pediatrics, 156, 5, DOI doi.org/10.1542/peds.2024-070516 (2025).

Sources:

preventallergies.org/blog/why-are-peanut-allergies-on-the-rise

chop.edu/news/childrens-hospital-philadelphia-researchers-observe-significant-reduction-diagnosis-food

thehill.com/policy/healthcare/5609536-rfk-jr-peanut-allergies-exposure-maha/

0:00 A disastrous recommendation

4:23 Historical allergy rates

5:58 “Rates have TRIPLED!!!”

8:48 Delayed exposure to peanuts drives allergies

10:43 An abundance of caution turns into assumptions made

14:54 Misinformation travels faster then good info

20:30 LEAP Trial shows early exposure reduces allergies

29:30 New guidelines show success

43:18 Wrap up and look ahead