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Conversation with Prof. Scott L. Friedman [Mount Sinai School of Medicine, New York]

https://diagnosticdetectives.com/liver/friedman/

Causes, diagnosis, treatment of NAFLD and NASH. Genetic tests. Supplements and generic drugs for NASH. Liver cancer risk. Coffee helps liver health. On importance of having a good mentor.

00:00 Biography: Liver expert, Prof. Scott L. Friedman

01:33 What is Fatty Liver Disease [NAFLD]? 

04:17 Non-obese patients with NAFLD. 

05:29 Diagnostic tests for NAFLD. 

06:31 Normal ALT, AST but bad NASH or NAFLD

07:40 FibroScan, MR Elastography to test for liver fibrosis

08:18 Can NAFLD be reversed?

09:34 How NASH differs from NAFLD?

10:16 What drives progression to NASH?

11:40 Genetic tests for risks of liver disease?

12:33 Microbiome and NAFLD / NASH?

14:09 Antibiotics in food lead to NAFLD / NASH.

16:06 ‘Auto-brewery syndrome’: gut makes alcohol?

17:56 Fecal microbiome transplantation for NASH?

20:29 Supplements and generics for NASH

20:48 Pharma is not interested in generics or supplements for NASH.

22:27 Hepatic Stellate Cells cause NAFLD / NASH?

28:30 Liver cancer and NASH / NAFLD?

32:03 How to personalize liver cancer screening in NASH?

34:27 Why no drugs approved for NASH?

38:28 Leading drug candidates for NASH therapy.

42:38 Repurposing generics for NASH therapy.

44:06 Statins for NASH and Heart risks?

45:00 Most NASH / NAFLD patients have NO symptoms

46:15 Coffee and liver health?

46:45 Coffee reduces risks of liver disease

48:13 Future of liver disease treatment.

49:56 Xenotransplantation for liver disease

51:15 Regeneration of liver: greatest mystery! 

52:17 Questions of patients with liver disease.

53:51 ‘No symptoms but advanced liver disease’

54:12 How to improve liver health?

54:30 Weight loss is best therapy for NASH / NAFLD

55:22 Patients’ fear: no symptoms but bad liver disease?

55:54 Alcohol rarely causes NAFLD / NASH

56:42 ‘Mentorship is key to successful career’ - Prof. Friedman

#liver #NAFLD #NASH #exercise #livercancer #mentorship #cirrhosis #obesity #weightloss #EHNA #cancerdehigado #esteatohepatitis #Leber #FettigeLebererkrankung #Leberkrebs #Zirrhose #stéatohépatite #cancerdufoie #foie #stéatosehépatique 

Conversation notes:

1:00 Professor Tobias Welte, leading Lung Expert. Biography. Introduction.

5:27 COVID-19 vaccines: efficacy, safety, how long immunity lasts.

11:51 COVID-19 vaccine fear, young people vaccination, herd immunity.

16:29 Immune response difference between adenovirus and mRNA-based COVID-19 vaccines.

19:56 New COVID-19 virus mutations. Will vaccines continue to be effective?

24:03 Long-term safety of coronavirus vaccines. How long will it take to find side effects?

28:52 Decrease in COVID-19 antibody levels with time. Is protection still present?

32:46 Vaccination AFTER recovery from COVID-19? When to get a coronavirus vaccine.

36:47 Problems with clinical trials of COVID-19 treatments.

40:12 ICU treatment of severe COVID-19. Germany vs. USA.

44:36 Long-haul COVID-19 and rehabilitation after coronavirus. Reasons for optimism.

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