Folinic acid has been showing up everywhere in conversations about autism—but what does the research actually tell us, and why should occupational therapists pay attention? In this episode of Ideas at Play, we break down a high-quality randomized controlled trial on folinic acid and translate the findings into practical, OT-relevant insights. We unpack the brain-based “why,” highlight what the study found (including changes related to autism characteristics and language), and talk about how this information fits into real-world practice. As always, we center participation, functional outcomes, and collaboration with families and medical teams. This episode is for informational purposes only and is not medical advice. Families should always consult their physician before starting or changing supplements or medications.

We share our own thoughts in the Research Review and encourage you to read the original article too.

Panda, P. K., Sharawat, I. K., Saha, S., Gupta, D., Palayullakandi, A., & Meena, K. (2024). Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: A randomized double-blind, placebo-controlled trial. European Journal of Pediatrics, 183(11), 4827–4835. https://doi.org/10.1007/s00431-024-05762-6

Additional Citations:

Sener, E. F., Oztop, D. B., & Ozkul, Y. (2014). MTHFR gene C677T polymorphism in autism spectrum disorders. Genetics Research International, 2014, Article 698574. https://doi.org/10.1155/2014/698574

Bobrowski-Khoury, N., Ramaekers, V. T., Sequeira, J. M., & Quadros, E. V. (2021). Folate receptor alpha autoantibodies in autism spectrum disorders: Diagnosis, treatment and prevention. Journal of Personalized Medicine, 11(8), Article 710. https://doi.org/10.3390/jpm11080710

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