Couverture de 57: Episode 56 - Precision Medicine: Mapping the Genetic Code for New Treatments

57: Episode 56 - Precision Medicine: Mapping the Genetic Code for New Treatments

57: Episode 56 - Precision Medicine: Mapping the Genetic Code for New Treatments

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 In this Quest Podcast episode, we chat with clinicians, Dr. Stephan Züchner, Dr. Conrad “Chris” Weihl, and the Interim Chief Research Officer of the Muscular Dystrophy Association, Dr. Angela Lek. Leaders in the field of genetic mapping, all three have devoted their time and expertise to research and treatments for neuromuscular diseases. Their goal is to map the genome for neuromuscular diseases, develop successful treatments, and ultimately find a cure for those effected by neuromuscular diseases. These specialists join us to share their experiences, expertise, and advice.

Transcript

Guests:

Dr. Stephan Züchner, M.D., Ph.D., is a Professor of Human Genetics and Neurology in the role of Chief Genomics Officer at the University of Miami Miller School of Medicine. He received his degrees from the University RWTH Aachen, Germany, and an honorary doctoral degree from the Semmelweis Medical School in Budapest. His research interests are focused on identifying strong genetic variation associated with disease. His lab has been involved in identifying over 100 neuromuscular disease genes, such as the MFN2, SARM1, and SORD. More recently he has made significant contributions to repeat expansion disorders, helping to discover RFC1, FGF14, ABCD3 and other loci. His lab also works on basic mechanisms and the genome biology of short tandem repeat loci. To further enhance the ability to identify pathogenic variation, his team has recently developed machine learning and AI tools that have successfully supported disease gene identification. All this is directed towards the genomics-to-therapy concept, whereby progress in genomics will directly, and at times rapidly, lead to therapeutic options to be tested in clinical trials. He also leads the GENESIS genome database and has leadership and advisory roles ClinGen, UDN/UDN-Foundation, CMT Association, All of Us Research Project, and Muscular Dystrophy Association.

Connect with Dr. Züchner:

  • X: https://x.com/szuchner
  • Website: https://www.tgp-foundation.org/
Dr. Conrad “Chris” Weihl is a Professor of Neurology, Head of the Neuromuscular Section and Director of the Muscular Dystrophy Association Clinic at Washington University School of Medicine in St. Louis, Missouri, USA. His research program focuses on both genetic and acquired myopathies with an emphasis on how dysfunction in protein quality controls lead to muscle degeneration. He began his career investigating the pathogenic mechanism of VCP disease mutations in muscle disease. Dr. Weihl has a strong commitment to the training of future neuromuscular clinicians and myologists and was awarded a K24 mid-career investigator award to mentor residents, fellows, junior faculty and early-stage scientists in patient oriented research. Clinically, Dr. Weihl sees patients in a multidisciplinary Muscular Dystrophy Association Care Center and recently established a center devoted to the care of patients with IBM.

Dr. Angela Lek is the Interim Chief Research Officer at the Muscular Dystrophy Association. Dr. Lek is a renowned scientist with over 15 years of experience in neuromuscular disease research. She now leads MDA’s global research portfolio and strategic direction — driving efforts to accelerate the development of treatments and cures for individuals living with neuromuscular diseases. She has trained and led research programs at institutions including Boston Children’s Hospital and Yale University and brings both deep scientific expertise and a personal commitment to advancing care and therapies for the neuromuscular community.

Host:

Mindy Henderson is MDA’s Vice President of Disability Outreach & Empowerment & Editor-in-Chief of Quest Media, and the host of this podcast. She was diagnosed with Spinal Muscular Atrophy, type 2 when she was 15 months old and has been a life-long partner to MDA. Mindy is also a motivational speaker and a writer, and author of the book, The Truth About Things That Suck.

Connect with Mindy:

  • LinkedIn: https://www.linkedin.com/in/hendersonmindy/
  • Instagram: https://www.instagram.com/mindyhendersonspeaks/
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