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The Angel and the Assassin

The Tiny Brain Cell That Changed the Course of Medicine
Lu par : Melinda Wade
Durée : 10 h et 8 min

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Description

A thrilling story of scientific detective work and medical potential that illuminates the newly understood role of microglia - an elusive type of brain cell that is vitally relevant to our everyday lives.

"The rarest of books: a combination of page-turning discovery and remarkably readable science journalism." (Mark Hyman, MD, number one New York Times best-selling author of Food: What the Heck Should I Eat?)

Until recently, microglia were thought to be merely the brain’s housekeepers, helpfully removing damaged cells. But a recent groundbreaking discovery revealed them to be capable of terrifying Jekyll and Hyde behavior. When triggered - and anything that stirs up the immune system in the body can activate microglia - they can morph into destroyers, impacting a wide range of issues from memory problems and anxiety to depression and Alzheimer’s. Under the right circumstances, however, microglia can be coaxed back into being angelic healers, able to repair the brain in ways that help alleviate symptoms and hold the promise to one day prevent disease.

A fascinating behind-the-scenes account of this cutting-edge science, The Angel and the Assassin also explores the medical implications of these game-changing discoveries. Award-winning journalist Donna Jackson Nakazawa began her investigation with a personal interest - when diagnosed with an autoimmune disorder years ago, she was convinced there was something physical going on in her brain as well as her body, though no doctor she consulted could explain how the two could be interacting in this way. With the compassion born of her own experience, she follows practitioners and patients on the front lines of treatments that help to "reboot" microglia - from neurofeedback and intermittent fasting to transcranial magnetic stimulation and gamma light flicker therapy. She witnesses patients finding significant relief from pressing symptoms - and at least one stunning recovery - offering new hope to the tens of millions who suffer from mental, cognitive, and physical health issues.

Proving once and for all the biological basis for the mind-body connection, the discovery of the true role of microglia stands to rewrite psychiatric and medical texts as we know them. Hailed as "riveting", "stunning", and "visionary", The Angel and the Assassin offers us a radically reconceived picture of human health and promises to change everything we thought we knew about how to heal ourselves.

©2020 Donna Jackson Nakazawa (P)2020 Random House Audio

Commentaires

"A fascinating deep dive into the unsung heroes (and villains) inside our skulls.... Donna Jackson Nakazawa has a journalist’s eye for story, a scholar’s understanding of the research, and a patient’s appreciation for how high the stakes truly are." (Susannah Cahalan, New York Times best-selling author of Brain on Fire)

 

"An inspiring account that will provide a game-changing view of health for generations of researchers, clinicians, and citizens for years to come. Bravo!" (Dan Siegel, MD, clinical professor, UCLA School of Medicine, and executive director of the Mindsight Institute)

"Riveting, engaging, and visionary." (Terry Wahls, MD, author of The Wahls Protocol)

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  • Global
    4 out of 5 stars
  • Interprétation
    2 out of 5 stars
  • Histoire
    5 out of 5 stars
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  • Dominic Acri
  • 23/01/2020

A Magnus Opus for Microglia

As a neuroscientist, I found this book a refreshing and accurate narrative of the current state of microglial research. Nakazawa brings popular science into the 21st Century of immunology and the brain, exploring cutting-edge research and highlighting some of the most influential scientists in the field. Weaving together narrative and science for the everyday listener, Nakazawa creates a beautiful tapestry befitting of this once understudied cell type.

Unfortunately, the performance of this audiobook was incredibly disappointing. The pronunciation of “microglia” throughout the book is frustrating and very distracting. Of the dozens of microglia researchers I work with, not a single one pronounces it this way. Other key words that are integral to the story of this book such as “tau” are mispronounced as well and make certain chapters hard to follow. That being said, this may not be a huge deal to those outside of the neuro-immune/AD fields. I expect better from Random House Audio, now I’ll think twice before buying science audiobooks from them in the future.

7 personnes ont trouvé cela utile

  • Global
    5 out of 5 stars
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    1 out of 5 stars
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    5 out of 5 stars
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  • Deb Lang
  • 05/02/2020

Microglia pronounced wrong by narrator

The book itself is excellent. Donna Jackson Nakazawa turns scientific information into an interesting and understandable story, and it wholeheartedly deserves five stars.

HOWEVER, the narrator mispronounced “microglia” throughout the book and it drove me crazy. I understand a new version is in process..I hope that Audible automatically replaces earlier purchases when it is completed. But seriously Audible, you should have better quality control than this!

3 personnes ont trouvé cela utile

  • Global
    3 out of 5 stars
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    4 out of 5 stars
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    3 out of 5 stars
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  • KWK
  • 25/05/2020

Good but too much fluff

Great approachable rendition of recent medical discoveries and research bring them to the mainstream. Absolutely too much minute by minute recounting of patient experiences. Slows down momentum and makes you wish you had a print version.

  • Global
    4 out of 5 stars
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    4 out of 5 stars
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    4 out of 5 stars
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  • Kei Jordan
  • 02/03/2020

Fascinating and interesting

Cons:
The first chapter is a little dull
There's a few too many people interest stories
The reader mispronounced many things

Pros:
Fantastic science
Short but engaging
Interesting treatment exploration
Medical, but not too complex

  • Global
    5 out of 5 stars
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    5 out of 5 stars
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    5 out of 5 stars
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  • Jay
  • 02/03/2020

Not all the answers, but gets to the root cause

Pretty rare for me to review a book before I'm done with it. This book is worth it just for the first couple of hours. Already bought the book as a gift for a few friends, as well. It's that good.

I'm not going to say it holds all the answers, but it may hold all the causations, from autism, to depression to Alzheimer's. Even though it raises a lot of questions, I found it very comforting to finally run into something that makes so much sense.

I have studied a lot of eastern philosophy. I did enjoy how it made the point that there is no separation of the mind and the body.

I thought this part from the book summed it up fairly well:

[S]cientist now refer to this process of excessive glial attacks on neurons and synaptic over pruning as neuroinflammation. Or, in diseases like Alzheimer's or Parkinson's as neurodegeneration.

In disorders like autism, obsessive-compulsive disorder and mood disorders. Neuroscientist call this process neural-developmental changes.

But, whatever term we use to refer to these brain changes, they all mean the same thing. Tiny microglia are engulfing and destroying synapses, and this is the catalyst that sets in motion hundreds of different disorders and diseases that have long remained the black box of psychiatry and neurology.

This means that the long held line in the sand between mental and physical health simply does not exist.

When an individual's immune system is over taxed, for some disease may show up in the brain. While for others, it may show up in the body. It could inflame your joins, or your mind, or both.

  • Global
    4 out of 5 stars
  • Interprétation
    2 out of 5 stars
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    4 out of 5 stars
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  • Julie
  • 27/02/2020

pronunciation of scientific terms is important!!!

this is an interesting review of the theory of microglial induced neuroimflammation and synapse destruction. Donna has highlighted a number if prominent scientists in the field and their peer reviewed work. some of the evidence she presents is weak though she does acknowledge these weaknesses often and emphasizes the need for ongoing research in the field.
she uses anecdotal experiences of individuals with applicable conditions like autoimmune diseases and psychiatric illness as a way to illustrate the principles she puts forth. i am less impressed with this aspect of her book.
she also presents some speculative treatments for microglial activation, again, with limited evidence.
the most annoying aspect of this audiobook is the narrator's mispronunciation of almost EVERY scientific term, including microglia (which is frequently mentioned). the term is pronounced pronounced mīcrō-glēa. it is absolutely painful to listen to for this reason. How do you avoid doing homework on the pronunciation of words you've never heard when narrating an entire book?! so sloppy and careless. despite this, the book is interesting and worth the listen if you're interested in neuroimflammation, though is certainly not a Bible for the topic.