A struggling Welsh town, a failing heart drug trial, and a ward full of men too embarrassed to admit what happened to them overnight.

The molecule in their veins was UK-92,480, weeks away from being cancelled.

Instead, it became Viagra, one of the most recognizable, profitable, and culturally disruptive drugs in modern medicine.

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Most of the things that quietly shape your life didn't arrive with fireworks. They arrived by accident, by mistake – or because one person, often in the wrong place at the wrong time, refused to accept 'this is just how it is'.

Dr. Vamsee Thalluri presents Break Through, where we tell the stories behind the medical breakthroughs that change the world. Each episode dives into a single breakthrough: a drug, a discovery, a technology. And you'll get the medicine too, but only what you need to make the story land.

Some breakthroughs are born from brilliance; others, from failure; others, from pure accident. But they all share one thing: a moment where someone notices something everyone else ignored, and decides to push – even when the world's telling them it's absolutely nothing.

Proudly hosted by P. Zinner Podcasts.

See omnystudio.com/listener for privacy information.

Breakthrough is a narrative podcast about the breakthroughs that reshaped medicine, and the people who forced them into existence.

Failed trials. Impossible problems. One overlooked clue.

Hosted by Dr Vamsee Thalluri, each episode pairs cinematic storytelling with clear medical explanation, so you understand the mechanism, the gamble, and the consequences.

See omnystudio.com/listener for privacy information.